DGIdb - CHRNB2 Gene Record

CHRNB2 1141 Druggable Genome

Alternate Names:

1141
CHOLINERGIC RECEPTOR NICOTINIC BETA 2 SUBUNIT
CHRNB2
EFNL3
nAChRB2
118507
1962
ENSG00000160716
OTTHUMG00000037262
Neuronal acetylcholine receptor subunit beta-2
P17787
NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787]
ACHB2_HUMAN
PA115
Neuronal acetylcholine receptor beta-2
T82543

Gene Info:

Target Class	Receptors
Target Subclass	TC:1.A.9
Human Readable Name	DRUGGABLE GENOME
Target Subclass	Ligand_gated_ion_channels
Target Subclass	cys-loop
Transmembrane Helix Count	4
Target Subclass	Channels
Target Main Class	Receptors
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Neur_channel
Interpro Short Name	Neur_chan_lig-bd
Interpro Name	Neurotransmitter-gated ion-channel ligand-binding
Interpro Type	Family
Interpro Acc	IPR006202
Uniprot Status	Swiss-Prot
Interpro Name	Neurotransmitter-gated ion-channel
Interpro Acc	IPR006201
Human Readable Name	ION CHANNEL
Interpro Type	Domain
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

ION CHANNEL
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Ehringer et al., 2007, Association of the neuronal nicotinic receptor beta2 subunit gene (CHRNB2) with subjective responses to alcohol and nicotine., Am. J. Med. Genet. B Neuropsychiatr. Genet.
Mansvelder et al., 2009, Nicotinic modulation of synaptic transmission and plasticity in cortico-limbic circuits., Semin. Cell Dev. Biol.
Zaniewska et al., Nicotine dependence - human and animal studies, current pharmacotherapies and future perspectives., Pharmacol Rep
Narahashi et al., 2000, Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior., Toxicol. Sci.
De Luca et al., 2006, Genetic interaction between alpha4 and beta2 subunits of high affinity nicotinic receptor: analysis in schizophrenia., Exp Brain Res
Jackson et al., 2010, Role of alpha5 nicotinic acetylcholine receptors in pharmacological and behavioral effects of nicotine in mice., J. Pharmacol. Exp. Ther.
Hoft NR et al., 2011, CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences., Genes Brain Behav
Matera C et al., 2015, Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization., Eur J Med Chem
Niaura R et al., 2006, Varenicline., Nat Rev Drug Discov
Rollema H et al., 2010, Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence., Br J Pharmacol

DEXMECAMYLAMINE CHRNB2

Interaction Score: 5.8

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TC-5214

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
ISPRONICLINE CHRNB2

Interaction Score: 3.86

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name TC-1734, AZD-3480, ispronicline

Novel drug target Established target

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
NICOTINE POLACRILEX CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TC-2216 CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALTINICLINE CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SOFINICLINE CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AZD1446 CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TEBANICLINE CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs:
None found

Sources:
ChemblInteractions
ABT-560 CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 modulator

PMIDs:
None found

Sources:
ChemblInteractions
VARENICLINE TARTRATE CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
POZANICLINE CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist

Direct Interaction yes

Trial Name pozanicline , ABT-089

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
TC-6499 CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name TC-6499

Novel drug target Established target

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CP-601927 CHRNB2

Interaction Score: 1.93

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions
CYTISINICLINE CHRNB2

Interaction Score: 1.55

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

PMIDs:
20331614

Sources:
TTD
VARENICLINE CHRNB2

Interaction Score: 1.1

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name varenicline, CP-526

Novel drug target Established target

PMIDs:
16883648

Sources:
TdgClinicalTrial
NICOTINE CHRNB2

Interaction Score: 1.05

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

Trial Name -

PMIDs:
17226798 19560048 20081230 11006350 16636791 20400469 20854418 26164842

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

Ensembl: ENSG00000160716
- Version: 101_38
Alternate Names:

CHRNB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000160716
- Version: 26-July-2011
Alternate Names:

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787] Description

ENSG00000160716 Ensembl Gene Id

CHRNB2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TEND: P17787
- Version: 01-August-2011
Alternate Names:

ACHB2_HUMAN Uniprot Id

1141 Entrez Gene Id

CHRNB2 Gene Symbol

Gene Info:

Target Subclass Ligand_gated_ion_channels

Target Subclass cys-loop

Transmembrane Helix Count 4

Publications:
TdgClinicalTrial: P17787
- Version: January-2014
Alternate Names:

CHRNB2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.9

Publications:
HopkinsGroom: P17787
- Version: 11-September-2012
Alternate Names:

ACHB2_HUMAN Uniprot Id

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 Uniprot Protein Name

P17787 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Short Name Neur_channel

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Publications:
PharmGKB: CHRNB2
- Version: 18-August-2020
Alternate Names:

PA115 PharmGKB ID

Gene Info:

Publications:

Hoft NR et al., 2011, CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences., Genes Brain Behav
DTC: CHRNB2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Matera C et al., 2015, Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization., Eur J Med Chem
ChemblInteractions: CHRNB2
- Version: chembl_23
Alternate Names:

CHRNB2 GENE_SYMBOL

Neuronal acetylcholine receptor subunit beta-2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000160716
- Version: 31-May-2017
Alternate Names:

ENSG00000160716 Gene Symbol

CHRNB2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Neuronal acetylcholine receptor beta-2
- Version: 2020.06.01
Alternate Names:

CHRNB2 TTD Gene Abbreviation

T82543 TTD Target ID

Gene Info:

Publications:
Pharos: CHRNB2
- Version: 01-February-2022
Alternate Names:

Neuronal acetylcholine receptor subunit beta-2 Gene Name

P17787 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:
GO: CHRNB2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Novel drug target	Established target
Trial Name	TC-5214
Mechanism of Interaction	Neuronal acetylcholine receptor; alpha4/beta2 antagonist

Trial Name	TC-1734, AZD-3480, ispronicline
Novel drug target	Established target
Mechanism of Interaction	Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

Mechanism of Interaction	Neuronal acetylcholine receptor; alpha4/beta2 agonist
Direct Interaction	yes

Mechanism of Interaction	Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist
Direct Interaction	yes
Trial Name	pozanicline , ABT-089

Trial Name	TC-6499
Novel drug target	Established target
Mechanism of Interaction	Neuronal acetylcholine receptor; alpha4/beta2 agonist

Trial Name	varenicline, CP-526
Novel drug target	Established target

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787]	Description
ENSG00000160716	Ensembl Gene Id
CHRNB2	Display Id

ACHB2_HUMAN	Uniprot Id
NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2	Uniprot Protein Name
P17787	Uniprot Accession

CHRNB2	GENE_SYMBOL
Neuronal acetylcholine receptor subunit beta-2	UNIPROT

Neuronal acetylcholine receptor subunit beta-2	Gene Name
P17787	UniProt ID

CHRNB2 Gene Record

CHRNB2 1141 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name TC-5214 Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Trial Name TC-1734, AZD-3480, ispronicline Novel drug target Established target Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Mechanism of Interaction Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist Direct Interaction yes Trial Name pozanicline , ABT-089

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name TC-6499 Novel drug target Established target Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: partial agonist (activating)

Interaction Info:

PMIDs: 20331614

Sources: TTD

Interaction Types & Directionality: partial agonist (activating)

Interaction Info: Trial Name varenicline, CP-526 Novel drug target Established target

PMIDs: 16883648

Sources: TdgClinicalTrial

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist Direct Interaction yes Trial Name -

PMIDs: 17226798 19560048 20081230 11006350 16636791 20400469 20854418 26164842

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

Ensembl: ENSG00000160716

Alternate Names: CHRNB2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000160716

Alternate Names: NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787] Description ENSG00000160716 Ensembl Gene Id CHRNB2 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TEND: P17787

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name TC-5214

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name TC-1734, AZD-3480, ispronicline

Novel drug target Established target

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Mechanism of Interaction Nicotinic acetylcholine receptor alpha4/beta2/alpha5 partial agonist

Direct Interaction yes

Trial Name pozanicline , ABT-089

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name TC-6499

Novel drug target Established target

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 partial agonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

partial agonist (activating)

PMIDs:
20331614

Sources:
TTD

Interaction Types & Directionality:

partial agonist (activating)

Interaction Info:

Trial Name varenicline, CP-526

Novel drug target Established target

PMIDs:
16883648

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Neuronal acetylcholine receptor; alpha4/beta2 agonist

Direct Interaction yes

Trial Name -

PMIDs:
17226798 19560048 20081230 11006350 16636791 20400469 20854418 26164842

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB

Alternate Names:

CHRNB2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

NEURONAL ACETYLCHOLINE RECEPTOR PROTEIN, BETA-2 SUBUNIT PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P17787] Description

ENSG00000160716 Ensembl Gene Id

CHRNB2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ACHB2_HUMAN Uniprot Id

1141 Entrez Gene Id

CHRNB2 Gene Symbol

Gene Info:

Target Subclass Ligand_gated_ion_channels

Target Subclass cys-loop

Transmembrane Helix Count 4

Alternate Names:

CHRNB2 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass TC:1.A.9

Alternate Names:

ACHB2_HUMAN Uniprot Id

NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2 Uniprot Protein Name

P17787 Uniprot Accession

Gene Info:

Uniprot Evidence 1: Evidence at protein level

Interpro Short Name Neur_channel

Human Readable Name DRUGGABLE GENOME

Gene Categories:

ION CHANNEL, DRUGGABLE GENOME

Alternate Names:

PA115 PharmGKB ID

Publications:

Hoft NR et al., 2011, CHRNB2 promoter region: association with subjective effects to nicotine and gene expression differences., Genes Brain Behav

Publications:

Matera C et al., 2015, Bifunctional compounds targeting both D2 and non-α7 nACh receptors: design, synthesis and pharmacological characterization., Eur J Med Chem

Alternate Names:

CHRNB2 GENE_SYMBOL

Neuronal acetylcholine receptor subunit beta-2 UNIPROT

Alternate Names:

ENSG00000160716 Gene Symbol

CHRNB2 Ensembl Id