DGIdb - CSF1R Gene Record

CSF1R 1436 Druggable GenomeClinically Actionable

Alternate Names:

1436
COLONY STIMULATING FACTOR 1 RECEPTOR
CSF1R
C-FMS
CD115
CSF-1R
CSFR
FIM2
FMS
HDLS
M-CSF-R
164770
2433
ENSG00000182578
OTTHUMG00000130050
P07333
CSF1R_HUMAN
MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR
CSF-1 receptor
Proto-oncogene c-Fms
CD_antigen=CD115
CSF-1-R
33
MACROPHAGE COLONY STIMULATING FACTOR I RECEPTOR PRECURSOR (CSF-1-R) (EC 2.7.1.112) (FMS PROTO-ONCOGENE) (C-FMS) (CD115 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07333]
Colony stimulating factor-1 receptor
T01110
T20333
BANDDOS
HDLS1

Gene Info:

Transmembrane Helix Count	1
Target Subclass	PDGFR
Target Main Class	Receptors
Target Subclass	KInase
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Uniprot Evidence	1: Evidence at protein level
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Acc	IPR001245
Interpro Type	Domain
Human Readable Name	KINASE
Uniprot Status	Swiss-Prot
Initial Gene Query	FMS
Counted Citations from 1950-2000	2517
CancerCommons Reported Gene Name	Receptor tyrosine kinases KIT, CSF1R, and FLT3
Target Class	Receptors
Target Subclass	EC:2.7.10.1
Gene Biotype	PROTEIN_CODING

(24 More Sources)

Gene Categories: Category Details

CELL SURFACE
KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Chase et al., 2009, Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1., Leukemia
Lilljebjörn et al., 2014, RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib., Leukemia
El Hajj Dib et al., 2006, Imatinib mesylate (Gleevec) enhances mature osteoclast apoptosis and suppresses osteoclast bone resorbing activity., Eur. J. Pharmacol.
Ando et al., 2006, Imatinib mesylate inhibits osteoclastogenesis and joint destruction in rats with collagen-induced arthritis (CIA)., J. Bone Miner. Metab.
Dewar et al., 2006, Imatinib as a potential antiresorptive therapy for bone disease., Blood
Dewar et al., 2005, Inhibition of c-fms by imatinib: expanding the spectrum of treatment., Cell Cycle
Taylor et al., 2006, FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance., Oncogene
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Tap et al., 2015, Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor., N. Engl. J. Med.
Mok et al., 2015, Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition., BMC Cancer
Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene
Cannarile MA et al., 2017, Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy., J Immunother Cancer
Roskoski, 2007, Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor., Biochem. Biophys. Res. Commun.
Guo et al., 2006, Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors., Mol. Cancer Ther.
Kimura et al., 1991, The biological effects of macrophage-colony-stimulating factor induced by progestin on growth and differentiation of endometrial adenocarcinoma cells., Int. J. Cancer
Ullrich et al., 2011, BAY 43-9006/Sorafenib blocks CSF1R activity and induces apoptosis in various classical Hodgkin lymphoma cell lines., Br. J. Haematol.

EDICOTINIB CSF1R

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
ARRY-382 CSF1R

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
PEXIDARTINIB CSF1R

Interaction Score: 1.93

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

Approval Status Phase I

PMIDs:
26222558 25939769 28759044 28716061

Sources:
MyCancerGenome JAX-CKB ChemblInteractions CIViC CancerCommons
PD-360324 CSF1R

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
IMC-CS4 CSF1R

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MCS-110 CSF1R

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CABIRALIZUMAB CSF1R

Interaction Score: 0.64

Interaction Types & Directionality:

antibody (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
PLX-5622 CSF1R

Interaction Score: 0.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VATALANIB CSF1R

Interaction Score: 0.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs:
28759044

Sources:
DTC ChemblInteractions CIViC
CT-1578 CSF1R

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLX-7486 CSF1R

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GW632580X CSF1R

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
IMATINIB CSF1R

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Variant Effect gain-of-function

Pathway activation

Clinical Status preclinical

PMIDs:
18971950 24186003 17049513 16816921 16449525 15917650 16170366

Sources:
DTC TdgClinicalTrial JAX-CKB TEND DoCM CIViC
SURUFATINIB CSF1R

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL365617 CSF1R

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
QUIZARTINIB CSF1R

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SUNITINIB MALATE CSF1R

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TANDUTINIB CSF1R

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAZOPANIB HYDROCHLORIDE CSF1R

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENMD-2076 CSF1R

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
SUNITINIB CSF1R

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17367763 16648572

Sources:
TEND
MASITINIB CSF1R

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
VEMURAFENIB CSF1R

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy PLX3397 + Vemurafenib

Indication/Tumor Type melanoma

Response Type sensitive

PMIDs:
25939769

Sources:
JAX-CKB
DOVITINIB CSF1R

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
28759044

Sources:
DTC ClearityFoundationClinicalTrial CIViC
LINIFANIB CSF1R

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Trial Name ABT-869, Linifanib

PMIDs:
None found

Sources:
DTC TdgClinicalTrial ChemblInteractions
SORAFENIB CSF1R

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type Hodgkin's lymphoma

Response Type sensitive

Approval Status Preclinical

PMIDs:
21517818

Sources:
DTC JAX-CKB
CHEMBL546797 CSF1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROGESTERONE CSF1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1831804

Sources:
NCI
AST-487 CSF1R

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL541400 CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
PAZOPANIB CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
GO-6976 CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DACTOLISIB CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEDIRANIB CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
KENPAULLONE CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 CSF1R

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 CSF1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB CSF1R

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DASATINIB CSF1R

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
RG-1530 CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB CSF1R

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000182578
- Version: 101_38
Alternate Names:

CSF1R Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P07333
- Version: 11-September-2012
Alternate Names:

CSF1R_HUMAN Uniprot Id

P07333 Uniprot Accession

MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR Uniprot Protein Name

Gene Info:

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Uniprot Evidence 1: Evidence at protein level

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P07333
- Version: January-2014
Alternate Names:

CSF1R Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass EC:2.7.10.1

Publications:
TEND: P07333
- Version: 01-August-2011
Alternate Names:

1436 Entrez Gene Id

CSF1R Gene Symbol

P07333 Uniprot Accession

Gene Info:

Transmembrane Helix Count 1

Target Subclass PDGFR

Target Main Class Receptors

Publications:
CancerCommons: CSF1R
- Version: 25-July-2013
Alternate Names:

1436 Entrez Gene ID

Gene Info:

CancerCommons Reported Gene Name Receptor tyrosine kinases KIT, CSF1R, and FLT3

Publications:
BaderLabGenes: CSF1R
- Version: February-2014
Alternate Names:

1436 Entrez Gene ID

Gene Info:

Initial Gene Query FMS

Counted Citations from 1950-2000 2517

Gene Categories:

KINASE

Publications:

RussLampel: ENSG00000182578

Version: 26-July-2011

Alternate Names:

ENSG00000182578 Ensembl Gene Id

CSF1R Display Id

MACROPHAGE COLONY STIMULATING FACTOR I RECEPTOR PRECURSOR (CSF-1-R) (EC 2.7.1.112) (FMS PROTO-ONCOGENE) (C-FMS) (CD115 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07333] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

JAX-CKB: CSF1R

Version: 27-September-2017

Alternate Names:

1436 CKB Entrez Id

CSF1R CKB Gene Synonym

C-FMS CKB Gene Synonym

Gene Info:

Publications:

Mok et al., 2015, Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition., BMC Cancer

Tap et al., 2015, Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor., N. Engl. J. Med.

Koh et al., 2014, CSF-1R expression in tumor-associated macrophages is associated with worse prognosis in classical Hodgkin lymphoma., Am. J. Clin. Pathol.

CIViC: CSF1R

Version: 14-September-2020

Alternate Names:

1436 Entrez Gene ID

33 CIViC Gene ID

Gene Info:

Publications:

Lilljebjörn et al., 2014, RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib., Leukemia

Yan D et al., 2017, Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas., Oncogene

NCI: CSF1R
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Kimura et al., 1991, The biological effects of macrophage-colony-stimulating factor induced by progestin on growth and differentiation of endometrial adenocarcinoma cells., Int. J. Cancer
DoCM: CSF1R
- Version: 27-September-2017
Alternate Names:

Gene Info:

Publications:

Chase et al., 2009, Imatinib sensitivity as a consequence of a CSF1R-Y571D mutation and CSF1/CSF1R signaling abnormalities in the cell line GDM1., Leukemia
DTC: CSF1R
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
TALC: FMS
- Version: 12-May-2016
Alternate Names:

FMS Gene Symbol

Gene Info:

Publications:
TALC: CSF1R
- Version: 12-May-2016
Alternate Names:

CSF1R Gene Symbol

Gene Info:

Publications:
ChemblInteractions: FMS
- Version: chembl_23
Alternate Names:

FMS GENE_SYMBOL

CSF1R GENE_SYMBOL

Macrophage colony-stimulating factor 1 receptor UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000182578
- Version: 31-May-2017
Alternate Names:

ENSG00000182578 Gene Symbol

CSF1R Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
MyCancerGenome: CSF1R
- Version: 20-Jun-2017
Alternate Names:

1436 Entrez Gene Id

CSF1R MyCancerGenome Gene Symbol

CSF-1R MyCancerGenome Reported Gene Name

Gene Info:

Publications:
GO: CSF1R
- Version: 01-February-2022
Alternate Names:

FMS GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, TYROSINE KINASE

Publications:
Tempus: CSF1R
- Version: 11-November-2018
Alternate Names:

CSF1R Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: CSF1R
- Version: 27-Jun-2013
Alternate Names:

1436 Gene ID

C-FMS dGene Synonym

CD115 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Colony stimulating factor-1 receptor
- Version: 2020.06.01
Alternate Names:

CSF-1R TTD Gene Abbreviation

T01110 TTD Target ID

Gene Info:

Publications:
TTD: Macrophage colony-stimulating factor 1 receptor
- Version: 2020.06.01
Alternate Names:

CSF1R TTD Gene Abbreviation

T20333 TTD Target ID

Gene Info:

Publications:
Pharos: CSF1R
- Version: 01-February-2022
Alternate Names:

Macrophage colony-stimulating factor 1 receptor Gene Name

P07333 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MskImpact: CSF1R
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: CSF1R
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: CSF1R
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: CSF1R
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: CSF1R
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Macrophage colony stimulating factor receptor inhibitor
Direct Interaction	yes

Variant Effect	gain-of-function
Pathway	activation
Clinical Status	preclinical

Trial Name	masitinib, AB1010
Novel drug target	Established target

combination therapy	PLX3397 + Vemurafenib
Indication/Tumor Type	melanoma
Response Type	sensitive

Indication/Tumor Type	Hodgkin's lymphoma
Response Type	sensitive
Approval Status	Preclinical

CSF1R_HUMAN	Uniprot Id
P07333	Uniprot Accession
MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR	Uniprot Protein Name

ENSG00000182578	Ensembl Gene Id
CSF1R	Display Id
MACROPHAGE COLONY STIMULATING FACTOR I RECEPTOR PRECURSOR (CSF-1-R) (EC 2.7.1.112) (FMS PROTO-ONCOGENE) (C-FMS) (CD115 ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P07333]	Description

FMS	GENE_SYMBOL
CSF1R	GENE_SYMBOL
Macrophage colony-stimulating factor 1 receptor	UNIPROT

1436	Entrez Gene Id
CSF1R	MyCancerGenome Gene Symbol
CSF-1R	MyCancerGenome Reported Gene Name

Macrophage colony-stimulating factor 1 receptor	Gene Name
P07333	UniProt ID

CSF1R Gene Record

CSF1R 1436 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes Approval Status Phase I

PMIDs: 26222558 25939769 28759044 28716061

Sources: MyCancerGenome JAX-CKB ChemblInteractions CIViC CancerCommons

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antibody (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs: 28759044

Sources: DTC ChemblInteractions CIViC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Variant Effect gain-of-function Pathway activation Clinical Status preclinical

PMIDs: 18971950 24186003 17049513 16816921 16449525 15917650 16170366

Sources: DTC TdgClinicalTrial JAX-CKB TEND DoCM CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

Approval Status Phase I

PMIDs:
26222558 25939769 28759044 28716061

Sources:
MyCancerGenome JAX-CKB ChemblInteractions CIViC CancerCommons

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antibody (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

PMIDs:
28759044

Sources:
DTC ChemblInteractions CIViC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Variant Effect gain-of-function

Pathway activation

Clinical Status preclinical

PMIDs:
18971950 24186003 17049513 16816921 16449525 15917650 16170366

Sources:
DTC TdgClinicalTrial JAX-CKB TEND DoCM CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17367763 16648572

Sources:
TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name masitinib, AB1010

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a