2147 |
COAGULATION FACTOR II, THROMBIN |
F2 |
PT |
RPRGL2 |
THPH1 |
176930 |
3535 |
ENSG00000180210 |
OTTHUMG00000150344 |
Activation peptide fragment 1 |
Prothrombin |
Activation peptide fragment 2 |
Thrombin light chain |
Thrombin heavy chain |
Coagulation factor II |
P00734 |
THRB_HUMAN |
PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] |
PA157 |
Coagulation factor IIa |
T94033 |
Interpro Acc | IPR001254 |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Peptidase_S1_S6 |
Interpro Name | Peptidase S1/S6, chymotrypsin/Hap |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Human Readable Name | PROTEASE |
Target Class | Enzymes |
Target Subclass | EC:3.4.21.5 |
Target Subclass | 3.4.21.5 |
Target Main Class | Enzymes |
Gene Biotype | PROTEIN_CODING |
GROWTH FACTOR |
PROTEASE |
EXTERNAL SIDE OF PLASMA MEMBRANE |
DRUGGABLE GENOME |
inhibitor (inhibitory) |
Trial Name | bivalirudin,Angiomax, Angiox |
Novel drug target | Established target |
Mechanism of Interaction | Thrombin inhibitor |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | Argatroban |
Mechanism of Interaction | Thrombin inhibitor |
inhibitor (inhibitory) |
Trial Name | lepirudin (rDNA) for injection,Refludan |
Novel drug target | Established target |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Thrombin inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Thrombin inhibitor |
n/a |
Novel drug target | Established target |
Trial Name | AZD-0837 |
inhibitor (inhibitory) |
Trial Name | Dabigatran |
Novel drug target | Established target |
Mechanism of Interaction | Thrombin inhibitor |
n/a |
Trial Name | Lovenox |
Novel drug target | Established target |
inhibitor (inhibitory) |
n/a |
Trial Name | octaparine, AVE-5026 |
Novel drug target | Established target |
F2 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
THRB_HUMAN | Uniprot Id |
PROTHROMBIN | Uniprot Protein Name |
P00734 | Uniprot Accession |
Interpro Acc | IPR001254 |
Human Readable Name | DRUGGABLE GENOME |
Uniprot Evidence | 1: Evidence at protein level |
PROTEASE, DRUGGABLE GENOME |
PROTHROMBIN PRECURSOR (EC 3.4.21.5) (COAGULATION FACTOR II). [SOURCE:UNIPROT/SWISSPROT;ACC:P00734] | Description |
F2 | Display Id |
ENSG00000180210 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
F2 | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.4.21.5 |
2147 | Entrez Gene Id |
F2 | Gene Symbol |
ENSG00000180210 | Ensembl Gene Id |
Target Subclass | 3.4.21.5 |
Target Main Class | Enzymes |
PA157 | PharmGKB ID |
F2 | TTD Gene Abbreviation |
T94033 | TTD Target ID |
F2 | GENE_SYMBOL |
Prothrombin | UNIPROT |
Activation peptide fragment 1 | UNIPROT |
ENSG00000180210 | Gene Symbol |
F2 | Ensembl Id |
DRUGGABLE GENOME |
2147 | Gene ID |
PT | dGene Synonym |
RPRGL2 | dGene Synonym |
PROTEASE |
GROWTH FACTOR, EXTERNAL SIDE OF PLASMA MEMBRANE |