GRIN2C Gene Record

  • GRIN2C 2905 Druggable Genome

    Alternate Names:

    2905
    GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 2C
    GRIN2C
    GluN2C
    NMDAR2C
    NR2C
    138254
    4587
    ENSG00000161509
    OTTHUMG00000044524
    Glutamate [NMDA] receptor subunit epsilon-3
    N-methyl D-aspartate receptor subtype 2C
    Glutamate receptor ionotropic, NMDA 2C
    Q14957
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 3 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2C) (NR2C) (NMDAR2C). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14957]
    NMDE3_HUMAN

    Gene Info:

    Target Subclass TC:1.A.10.1.3
    Target Class Receptors
    Human Readable Name DRUGGABLE GENOME
    Interpro Acc IPR001320
    Interpro Type Domain
    Uniprot Evidence 2: Evidence at transcript level
    Interpro Name Ionotropic glutamate receptor
    Interpro Short Name Iontro_glu_rcpt
    Uniprot Status Swiss-Prot
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    ION CHANNEL
    DRUGGABLE GENOME

    Publications:

  • CNS-5161   GRIN2C

    Interaction Score: 0.77

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name CNS-5161
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ESKETAMINE HYDROCHLORIDE   GRIN2C

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AM-101
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • LANICEMINE   GRIN2C

    Interaction Score: 0.77

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Trial Name AZD-6765
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor blocker

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DIMIRACETAM   GRIN2C

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name dimiracetam, NT-11624
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • INDANTADOL   GRIN2C

    Interaction Score: 0.6

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name V3381
    Novel drug target Novel Target
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • KETAMINE HYDROCHLORIDE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • MEMANTINE HYDROCHLORIDE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RAPASTINEL   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ESKETAMINE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AZD8108   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DELUCEMINE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LATREPIRDINE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Dimebon
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • NEBOGLAMINE   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    positive modulator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor positive allosteric modulator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AV-101   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • APIMOSTINEL   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    partial agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor partial agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GW468816   GRIN2C

    Interaction Score: 0.38

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • AMANTADINE HYDROCHLORIDE   GRIN2C

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NERAMEXANE MESYLATE   GRIN2C

    Interaction Score: 0.3

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FELBAMATE   GRIN2C

    Interaction Score: 0.22

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RALFINAMIDE   GRIN2C

    Interaction Score: 0.14

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE HYDROCHLORIDE   GRIN2C

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ORPHENADRINE CITRATE   GRIN2C

    Interaction Score: 0.13

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ACAMPROSATE CALCIUM   GRIN2C

    Interaction Score: 0.11

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Glutamate [NMDA] receptor antagonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000161509

    • Version: 101_38

    Alternate Names:
    GRIN2C Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: Q14957

    • Version: 11-September-2012

    Alternate Names:
    Q14957 Uniprot Accession
    NMDE3_HUMAN Uniprot Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON-3 Uniprot Protein Name

    Gene Info:
    Interpro Acc IPR001320
    Interpro Type Domain
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: Q14957

    • Version: January-2014

    Alternate Names:
    GRIN2C Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass TC:1.A.10.1.3

    Publications:

  • RussLampel: ENSG00000161509

    • Version: 26-July-2011

    Alternate Names:
    GRIN2C Display Id
    ENSG00000161509 Ensembl Gene Id
    GLUTAMATE [NMDA] RECEPTOR SUBUNIT EPSILON 3 PRECURSOR (N-METHYL D- ASPARTATE RECEPTOR SUBTYPE 2C) (NR2C) (NMDAR2C). [SOURCE:UNIPROT/SWISSPROT;ACC:Q14957] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: GRIN2C

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Jackson et al., 2006, Protein kinase C enhances glycine-insensitive desensitization of NMDA receptors independently of previously identified protein kinase C sites., J. Neurochem.

  • ChemblInteractions: NMDAR2C

    • Version: chembl_23

    Alternate Names:
    NMDAR2C GENE_SYMBOL
    GRIN2C GENE_SYMBOL
    Glutamate receptor ionotropic, NMDA 2C UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000161509

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000161509 Gene Symbol
    GRIN2C Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: GRIN2C

    • Version: 01-February-2022

    Alternate Names:
    Glutamate receptor ionotropic, NMDA 2C Gene Name
    Q14957 UniProt ID

    Gene Info:

    Gene Categories:
    ION CHANNEL

    Publications: