DGIdb - ESKETAMINE Drug Record

ESKETAMINE chembl:CHEMBL395091 Approved

Alternate Names:

ESKETAMINE
SPRAVATO
(S)-KETAMINE
(-)-KETAMINE
(S)-(-)-KETAMINE
(S)-2-(O-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXANONE
KETANEST
pubchem.compound:182137
chembl:CHEMBL395091
drugbank:11823
chemidplus:33643-46-8

Drug Info:

(0 More Sources)

Publications:

Molero P et al., 2018, Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review., CNS Drugs
Morrison RL et al., 2018, Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study., Psychopharmacology (Berl)

ESKETAMINE GRIN2B

Interaction Score: 0.46

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
ChemblInteractions
ESKETAMINE GRIN1

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
ChemblInteractions
ESKETAMINE GRIN2C

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN3B

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2D

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN3A

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TTD: Esketamine
- Version: 2020.06.01
Alternate Names:

D0TP5H TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL395091
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL395091
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator

ESKETAMINE Drug Record

ESKETAMINE chembl:CHEMBL395091 Approved

Alternate Names:

Drug Info:

Publications:

ESKETAMINE GRIN2B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29736744

Sources: ChemblInteractions

ESKETAMINE GRIN1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29392371

Sources: ChemblInteractions

ESKETAMINE GRIN2C

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ESKETAMINE GRIN3B

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ESKETAMINE GRIN2D

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ESKETAMINE GRIN2A

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ESKETAMINE GRIN3A

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TTD: Esketamine

Alternate Names: D0TP5H TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL395091

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL395091

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

D0TP5H TTD Drug ID