DGIdb - HTR1D Gene Record

HTR1D 3352 Druggable Genome

Alternate Names:

3352
5-HYDROXYTRYPTAMINE RECEPTOR 1D
HTR1D
5-HT1D
HT1DA
HTR1DA
HTRL
RDC4
182133
5289
ENSG00000179546
OTTHUMG00000003235
5-HT-1D
5-HT-1D-alpha
Serotonin receptor 1D
Serotonin 1D alpha receptor
P28221
5HT1D_HUMAN
5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR 1D) (5- HT-1D-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28221]
5-HT 1D receptor
T11072

Gene Info:

Interpro Type	Family
Interpro Name	GPCR, rhodopsin-like, 7TM
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000276
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	7TM_GPCR_Rhodpsn
Uniprot Evidence	2: Evidence at transcript level
Target Class	Receptors
Target Subclass	GPCR
Target Subclass	Rhodopsin
Transmembrane Helix Count	7
Target Main Class	Receptors
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Lovenberg et al., 1993, Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes., Proc. Natl. Acad. Sci. U.S.A.
Silberstein et al., 2003, Ergotamine and dihydroergotamine: history, pharmacology, and efficacy., Headache
Sánchez-Lopez et al., 2003, Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT1 and putative 5-ht5A/5B receptors., Br. J. Pharmacol.
Deliganis et al., 1991, 5-Hydroxtryptamine1D receptor agonism predicts antimigraine efficacy., Headache
Hoyer et al., 1992, "5-HT1R" or 5-HT1D sites? Evidence for 5-HT1D binding sites in rabbit brain., Naunyn Schmiedebergs Arch. Pharmacol.
Mitsikostas et al., 2002, 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis., Cephalalgia
Roy et al., 2000, Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves., J. Heart Valve Dis.
Mitsikostas et al., 1999, Both 5-HT1B and 5-HT1F receptors modulate c-fos expression within rat trigeminal nucleus caudalis., Eur. J. Pharmacol.
Nikai et al., 2008, Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan., Pain
Zohar et al., 2004, Serotonin-1D hypothesis of obsessive-compulsive disorder: an update., J Clin Psychiatry
Razzaque et al., 2002, 5-HT1B-receptors and vascular reactivity in human isolated blood vessels: assessment of the potential craniovascular selectivity of sumatriptan., Br J Clin Pharmacol
Baxter, 2001, Brain mediation of Anolis social dominance displays. III. Differential forebrain 3H-sumatriptan binding in dominant vs. submissive males., Brain Behav. Evol.
Akin et al., 2002, Involvement of 5-HT1B and 5-HT1D receptors in sumatriptan mediated vasocontractile response in rabbit common carotid artery., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Koran et al., 2001, Sumatriptan, 5-HT(1D) receptors and obsessive-compulsive disorder., Eur Neuropsychopharmacol
Cohen et al., 1999, 5-Hydroxytryptamine(1A) receptor activation enhances norepinephrine release from nerves in the rabbit saphenous vein., J. Pharmacol. Exp. Ther.
Richelson et al., 2000, Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds., Life Sci.
Seeger et al., 1995, Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity., J. Pharmacol. Exp. Ther.
Sprouse et al., 1999, Comparison of the novel antipsychotic ziprasidone with clozapine and olanzapine: inhibition of dorsal raphe cell firing and the role of 5-HT1A receptor activation., Neuropsychopharmacology
Wilner et al., 2002, The anxiolytic effect of the novel antipsychotic ziprasidone compared with diazepam in subjects anxious before dental surgery., J Clin Psychopharmacol
Stahl et al., 2003, The psychopharmacology of ziprasidone: receptor-binding properties and real-world psychiatric practice., J Clin Psychiatry
Cates ME, 2003, Ziprasidone--not an option for serotonin syndrome., CMAJ
Martin, 1997, Pre-clinical pharmacology of zolmitriptan (Zomig; formerly 311C90), a centrally and peripherally acting 5HT1B/1D agonist for migraine., Cephalalgia
Pascual, 1998, [Mechanism of action of zolmitriptan]., Neurologia
Hargreaves et al., 1999, Pathophysiology of migraine--new insights., Can J Neurol Sci
Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
de Almeida et al., 2001, Zolmitriptan--a 5-HT1B/D agonist, alcohol, and aggression in mice., Psychopharmacology (Berl.)
Gowin et al., 2010, Zolmitriptan and human aggression: interaction with alcohol., Psychopharmacology (Berl.)
Whale et al., 1999, Zolmitriptan-induced growth hormone release in humans: mediation by 5-HT1D receptors?, Psychopharmacology (Berl.)
Reuter et al., 2004, Effects of chronic sumatriptan and zolmitriptan treatment on 5-HT receptor expression and function in rats., Cephalalgia
Le Grand et al., 2000, Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors., Eur. J. Pharmacol.
Rubio-Beltrán E et al., 2018, Is selective 5-HT<sub>1F</sub> receptor agonism an entity apart from that of the triptans in antimigraine therapy?, Pharmacol Ther
Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
Akin et al., 2002, Agonist-directed trafficking explaining the difference between response pattern of naratriptan and sumatriptan in rabbit common carotid artery., Br. J. Pharmacol.
Massiou, 2001, Naratriptan., Curr Med Res Opin
Pauwels et al., 1996, Selective antagonism of human 5-HT1D and 5-HT1B receptor-mediated responses in stably transfected C6-glial cells by ketanserin and GR 127,935., Eur. J. Pharmacol.
Johnston et al., 2010, Triptans for the management of migraine., Drugs
Lambert, 2005, Preclinical neuropharmacology of naratriptan., CNS Drug Rev
Boers et al., 2004, Naratriptan has a selective inhibitory effect on trigeminovascular neurones at central 5-HT1A and 5-HT(1B/1D) receptors in the cat: implications for migraine therapy., Cephalalgia
Dulli, 1999, Naratriptan: an alternative for migraine., Ann Pharmacother
Donaldson et al., 2002, The role of 5-HT1B and 5-HT1D receptors in the selective inhibitory effect of naratriptan on trigeminovascular neurons., Neuropharmacology
Hoskin et al., 2004, The 5-hydroxytryptamine1B/1D/1F receptor agonists eletriptan and naratriptan inhibit trigeminovascular input to the nucleus tractus solitarius in the cat., Brain Res.
Villalón et al., 2004, 5-HT1B receptors and alpha 2A/2C-adrenoceptors mediate external carotid vasoconstriction to dihydroergotamine., Eur. J. Pharmacol.
Lesage et al., 1998, Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines., Br. J. Pharmacol.
Buzzi et al., 1992, The trigemino-vascular system and migraine., Pathol. Biol.
Buzzi et al., 1992, 5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation., Brain Res.
Jähnichen et al., 2004, Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery., Naunyn Schmiedebergs Arch. Pharmacol.
Comer, 2002, Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan., Headache
Parsons et al., 1998, Effects of the novel high-affinity 5-HT(1B/1D)-receptor ligand frovatriptan in human isolated basilar and coronary arteries., J. Cardiovasc. Pharmacol.
Elkind et al., 2004, Pharmacokinetics of frovatriptan in adolescent migraineurs., J Clin Pharmacol
Buchan et al., 2002, Frovatriptan: a review of drug-drug interactions., Headache
Balbisi, 2006, Frovatriptan: a review of pharmacology, pharmacokinetics and clinical potential in the treatment of menstrual migraine., Ther Clin Risk Manag
Easthope et al., 2001, Frovatriptan., CNS Drugs
Deleu et al., 2000, Current and emerging second-generation triptans in acute migraine therapy: a comparative review., J Clin Pharmacol
Balbisi, 2004, Frovatriptan succinate, a 5-HT1B/1D receptor agonist for migraine., Int. J. Clin. Pract.
Wellington et al., 2002, Rizatriptan: an update of its use in the management of migraine., Drugs
Wellington et al., 2002, Spotlight on rizatriptan in migraine., CNS Drugs
Sciberras et al., 1997, Initial human experience with MK-462 (rizatriptan): a novel 5-HT1D agonist., Br J Clin Pharmacol
Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
Williamson et al., 2001, The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs., Br. J. Pharmacol.
Longmore et al., 1996, 5-HT1D receptor agonists and human coronary artery reactivity in vitro: crossover comparisons of 5-HT and sumatriptan with rizatriptan and L-741,519., Br J Clin Pharmacol
Longmore et al., Comparison of the vasoconstrictor properties of the 5-HT1D-receptor agonists rizatriptan (MK-462) and sumatriptan in human isolated coronary artery: outcome of two independent studies using different experimental protocols., Funct. Neurol.
Ikemoto et al., 2004, [Rizatriptan (Maxalt), a new entity of triptan for migraine: pharmacology and therapeutic relevance]., Nippon Yakurigaku Zasshi
Nasrallah, 2008, Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles., Mol. Psychiatry
Gras et al., 2001, Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics., Arzneimittelforschung
Bou et al., 2000, Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine., Eur. J. Pharmacol.
Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs
Leslie CP et al., 2010, Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist., J Med Chem

FROVATRIPTAN HTR1D

Interaction Score: 18.82

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name frovatriptan,Frovelan, Frova

Novel drug target Established target

PMIDs:
15185063 11152011 12028320 9700983 15342617 12028322 11752352 18360605 11735616 10883409 15311727

Sources:
TdgClinicalTrial TEND TTD
RIZATRIPTAN HTR1D

Interaction Score: 16.13

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12093318 12269863 9056052 15821444 11487512 8904614 9127118 11752352 15056946

Sources:
TdgClinicalTrial TEND TTD
NARATRIPTAN HTR1D

Interaction Score: 9.41

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name naratriptan,Naramig, Amerge

Novel drug target Established target

PMIDs:
11152011 12010764 12463278 10563228 8741180 20687618 16389295 14728705 10410185 11752352 11897116 14725972

Sources:
TdgClinicalTrial TEND
ERGOTAMINE HTR1D

Interaction Score: 9.41

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8384716 12558771 14504136 1646776 1407010

Sources:
TdgClinicalTrial TEND
ZOLMITRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name zolmitriptan,Zomig

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ELETRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

PMIDs:
11152011 15821444 10193663 11513839 11752352 12498013

Sources:
TdgClinicalTrial TEND TTD
ALMOTRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
11642004 11134654 11752352 10193663

Sources:
TdgClinicalTrial TEND
TONABERSAT HTR1D

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Tonabersat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
CHEMBL490417 HTR1D

Interaction Score: 5.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21053897

Sources:
DTC
DIHYDROERGOTAMINE HTR1D

Interaction Score: 4.84

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MAP-0004, TEMPO Migraine,Levadex

Novel drug target Established target

Trial Name MT 300

PMIDs:
14744615 12558771 9605573 1379707 1324091 11752352 1407010

Sources:
TdgClinicalTrial TEND
SUMATRIPTAN HTR1D

Interaction Score: 2.88

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

Trial Name MT 400,Treximet

PMIDs:
12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DONITRIPTAN HTR1D

Interaction Score: 1.79

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
SUMATRIPTAN SUCCINATE HTR1D

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FROVATRIPTAN SUCCINATE HTR1D

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIHYDROERGOTAMINE MESYLATE HTR1D

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RIZATRIPTAN BENZOATE HTR1D

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NARATRIPTAN HYDROCHLORIDE HTR1D

Interaction Score: 1.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ZIPRASIDONE HTR1D

Interaction Score: 1.05

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

PMIDs:
11132243 7562537 10516958 11910268 14728084 14638642

Sources:
TEND
ELETRIPTAN HYDROBROMIDE HTR1D

Interaction Score: 0.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ALMOTRIPTAN MALATE HTR1D

Interaction Score: 0.9

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIROMELATINE HTR1D

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GSK163090 HTR1D

Interaction Score: 0.67

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OLANZAPINE HTR1D

Interaction Score: 0.08

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

Interaction Info:

Trial Name ALKS 3831

Novel drug target Established target

Trial Name olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

PMIDs:
17848919

Sources:
TdgClinicalTrial

Ensembl: ENSG00000179546
- Version: 101_38
Alternate Names:

HTR1D Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P28221
- Version: 01-August-2011
Alternate Names:

5HT1D_HUMAN Uniprot Id

3352 Entrez Gene Id

ENSG00000179546 Ensembl Gene Id

Gene Info:

Target Subclass GPCR

Transmembrane Helix Count 7

Target Subclass Rhodopsin

Publications:
TdgClinicalTrial: P28221
- Version: January-2014
Alternate Names:

HTR1D Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:

RussLampel: ENSG00000179546

Version: 26-July-2011

Alternate Names:

HTR1D Display Id

5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR 1D) (5- HT-1D-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28221] Description

ENSG00000179546 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: P28221
- Version: 11-September-2012
Alternate Names:

3352 Entrez Gene Id

P28221 Uniprot Accession

ENSG00000179546 Ensembl Gene Id

Gene Info:

Interpro Type Family

Interpro Name GPCR, rhodopsin-like, 7TM

Uniprot Status Swiss-Prot

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:

DTC: HTR1D

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Leslie CP et al., 2010, Discovery of 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a Potent, selective, and orally active 5-HT1A/B/D receptor antagonist., J Med Chem

ChemblInteractions: HTR1DA
- Version: chembl_23
Alternate Names:

5-HT-1D UNIPROT

HTRL GENE_SYMBOL

HTR1D GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000179546
- Version: 31-May-2017
Alternate Names:

ENSG00000179546 Gene Symbol

HTR1D Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
dGene: HTR1D
- Version: 27-Jun-2013
Alternate Names:

3352 Gene ID

5-HT1D dGene Synonym

HT1DA dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: 5-HT 1D receptor
- Version: 2020.06.01
Alternate Names:

HTR1D TTD Gene Abbreviation

T11072 TTD Target ID

Gene Info:

Publications:

Trial Name	frovatriptan,Frovelan, Frova
Novel drug target	Established target

Trial Name	naratriptan,Naramig, Amerge
Novel drug target	Established target

Trial Name	almotriptan,Axert, Almogran, Amignul
Novel drug target	Established target

Trial Name	MAP-0004, TEMPO Migraine,Levadex
Novel drug target	Established target
Trial Name	MT 300

Mechanism of Interaction	Serotonin 1d (5-HT1d) receptor agonist
Direct Interaction	yes
Trial Name	MT 400,Treximet

Mechanism of Interaction	Serotonin 1d (5-HT1d) receptor antagonist
Direct Interaction	yes

Trial Name	ALKS 3831
Novel drug target	Established target
Trial Name	olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv

5HT1D_HUMAN	Uniprot Id
3352	Entrez Gene Id
ENSG00000179546	Ensembl Gene Id

HTR1D	Display Id
5-HYDROXYTRYPTAMINE 1D RECEPTOR (5-HT-1D) (SEROTONIN RECEPTOR 1D) (5- HT-1D-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P28221]	Description
ENSG00000179546	Ensembl Gene Id

agonist (activating)
antagonist (inhibitory)

HTR1D Gene Record

HTR1D 3352 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name frovatriptan,Frovelan, Frova Novel drug target Established target

PMIDs: 15185063 11152011 12028320 9700983 15342617 12028322 11752352 18360605 11735616 10883409 15311727

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 12093318 12269863 9056052 15821444 11487512 8904614 9127118 11752352 15056946

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name naratriptan,Naramig, Amerge Novel drug target Established target

PMIDs: 11152011 12010764 12463278 10563228 8741180 20687618 16389295 14728705 10410185 11752352 11897116 14725972

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 8384716 12558771 14504136 1646776 1407010

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name zolmitriptan,Zomig Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs: 9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Relpax Novel drug target Established target

PMIDs: 11152011 15821444 10193663 11513839 11752352 12498013

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name almotriptan,Axert, Almogran, Amignul Novel drug target Established target

PMIDs: 11642004 11134654 11752352 10193663

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Tonabersat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21053897

Sources: DTC

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MAP-0004, TEMPO Migraine,Levadex Novel drug target Established target Trial Name MT 300

PMIDs: 14744615 12558771 9605573 1379707 1324091 11752352 1407010

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes Trial Name MT 400,Treximet

PMIDs: 12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: agonist (activating) antagonist (inhibitory)

Interaction Info:

PMIDs: 11132243 7562537 10516958 11910268 14728084 14638642

Sources: TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist Direct Interaction yes

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name frovatriptan,Frovelan, Frova

Novel drug target Established target

PMIDs:
15185063 11152011 12028320 9700983 15342617 12028322 11752352 18360605 11735616 10883409 15311727

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
12093318 12269863 9056052 15821444 11487512 8904614 9127118 11752352 15056946

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name naratriptan,Naramig, Amerge

Novel drug target Established target

PMIDs:
11152011 12010764 12463278 10563228 8741180 20687618 16389295 14728705 10410185 11752352 11897116 14725972

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
8384716 12558771 14504136 1646776 1407010

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name zolmitriptan,Zomig

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

PMIDs:
9399012 9859690 10563228 11513839 11594437 20407761 10463324 11752352 15096229 10844127 29352859

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

PMIDs:
11152011 15821444 10193663 11513839 11752352 12498013

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
11642004 11134654 11752352 10193663

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Tonabersat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
21053897

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MAP-0004, TEMPO Migraine,Levadex

Novel drug target Established target

Trial Name MT 300

PMIDs:
14744615 12558771 9605573 1379707 1324091 11752352 1407010

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

Trial Name MT 400,Treximet

PMIDs:
12110114 10772044 10225363 18723285 15554784 11874390 11641558 12010765 11752352 11313163 10454495

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

antagonist (inhibitory)

PMIDs:
11132243 7562537 10516958 11910268 14728084 14638642

Sources:
TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Serotonin 1d (5-HT1d) receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found