DGIdb - ALMOTRIPTAN Drug Record

ALMOTRIPTAN chembl:CHEMBL1505 Approved

Alternate Names:

ALMOTRIPTAN
LAS-31416
1-(((3-(2-(DIMETHYLAMINO)ETHYL)INDOL-5-YL)METHYL)SULFONYL)PYRROLIDINE
AXERT®
PNU-180638E
chembl:CHEMBL1505
rxcui:279645
pubchem.compound:123606
chemidplus:154323-57-6
drugbank:00918

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antimigraine agent
Year of Approval	2001
Drug Class	anti-migraine agents

(0 More Sources)

Publications:

Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
Bou et al., 2000, Pharmacological characterization of almotriptan: an indolic 5-HT receptor agonist for the treatment of migraine., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fleishaker et al., 2000, Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers., Clin. Pharmacol. Ther.
Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
Gras et al., 2001, Safety profile of almotriptan, a new antimigraine agent. Effects on central nervous system, renal function and respiratory dynamics., Arzneimittelforschung

ALMOTRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
11642004 11134654 11752352 10193663

Sources:
TdgClinicalTrial TEND
ALMOTRIPTAN HTR1B

Interaction Score: 7.49

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
10193663 11050304 11134654 11752352 10824628 11069595

Sources:
TdgClinicalTrial TEND

TEND: ALMOTRIPTAN
- Version: 01-August-2011
Alternate Names:

ALMOTRIPTAN Primary Drug Name

Drug Info:

Drug Class anti-migraine agents

Year of Approval 2001

Publications:
TdgClinicalTrial: ALMOTRIPTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved

Publications:
ChemblDrugs: chembl:CHEMBL1505
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	almotriptan,Axert, Almogran, Amignul
Novel drug target	Established target

ALMOTRIPTAN Drug Record

ALMOTRIPTAN chembl:CHEMBL1505 Approved

Alternate Names:

Drug Info:

Publications:

ALMOTRIPTAN HTR1D

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name almotriptan,Axert, Almogran, Amignul Novel drug target Established target

PMIDs: 11642004 11134654 11752352 10193663

Sources: TdgClinicalTrial TEND

ALMOTRIPTAN HTR1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name almotriptan,Axert, Almogran, Amignul Novel drug target Established target

PMIDs: 10193663 11050304 11134654 11752352 10824628 11069595

Sources: TdgClinicalTrial TEND

TEND: ALMOTRIPTAN

Alternate Names: ALMOTRIPTAN Primary Drug Name

Drug Info: Drug Class anti-migraine agents Year of Approval 2001

Publications:

TdgClinicalTrial: ALMOTRIPTAN

Alternate Names:

Drug Info: Drug Indications antimigraine agent Drug Class Small Molecule FDA Approval approved

Publications:

ChemblDrugs: chembl:CHEMBL1505

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
11642004 11134654 11752352 10193663

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name almotriptan,Axert, Almogran, Amignul

Novel drug target Established target

PMIDs:
10193663 11050304 11134654 11752352 10824628 11069595

Sources:
TdgClinicalTrial TEND

Alternate Names:

ALMOTRIPTAN Primary Drug Name

Drug Info:

Drug Class anti-migraine agents

Year of Approval 2001

Drug Info:

Drug Indications antimigraine agent

Drug Class Small Molecule

FDA Approval approved