3359 |
5-HYDROXYTRYPTAMINE RECEPTOR 3A |
HTR3A |
5-HT-3 |
5-HT3A |
5-HT3R |
5HT3R |
HTR3 |
182139 |
5297 |
ENSG00000166736 |
OTTHUMG00000160494 |
PA29555 |
5-HYDROXYTRYPTAMINE 3 RECEPTOR PRECURSOR (5-HT-3) (SEROTONIN-GATED ION CHANNEL RECEPTOR) (5-HT3R). [SOURCE:UNIPROT/SWISSPROT;ACC:P46098] |
P46098 |
Q13639 |
HTR4 |
SEROTONIN-GATED ION CHANNEL RECEPTOR |
SEROTONIN RECEPTOR 3A |
5-HT3-A |
5-hydroxytryptamine receptor 3 |
5HT3A_HUMAN |
5-HT 3 receptor |
T84160 |
5-HT 3A receptor |
T64591 |
Human Readable Name | DRUGGABLE GENOME |
Target Class | Receptors |
Target Subclass | TC:1.A.9.2.1 |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
Target Subclass | Channels |
Target Subclass | cys-loop |
Target Subclass | Ligand_gated_ion_channels |
Transmembrane Helix Count | 4 |
Target Main Class | Receptors |
Interpro Type | Domain |
Interpro Short Name | Neur_chan_lig-bd |
Uniprot Status | Swiss-Prot |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Family |
Interpro Short Name | Neur_channel |
Interpro Name | Neurotransmitter-gated ion-channel ligand-binding |
Human Readable Name | ION CHANNEL |
Interpro Acc | IPR006202 |
Interpro Acc | IPR006201 |
Interpro Name | Neurotransmitter-gated ion-channel |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3 (5-HT3) receptor antagonist |
Direct Interaction | yes |
Trial Name | cilansetron |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Trial Name | BGC20-0166 |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
Trial Name | APF530, granisetron |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
agonist (activating) |
Trial Name | - |
Novel drug target | Established target |
antagonist (inhibitory) |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | renzapride |
Novel drug target | Established target |
n/a |
Trial Name | tegaserod,Zelnorm, Zelmac |
Novel drug target | Established target |
n/a |
Trial Name | prucalopride ,Resolor |
Novel drug target | Established target |
n/a |
Trial Name | mosapride citrate, TAK-370,Gasmotin |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | velusetrag, TD-5108 |
n/a |
Trial Name | ATI-7505 |
Novel drug target | Established target |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
n/a |
Novel drug target | Established target |
Trial Name | Pumosetrag |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Lu AA21004 |
antagonist (inhibitory) |
Trial Name | rocuronium bromide,Esmeron, Zemuron, Eslax |
Novel drug target | Established target |
n/a |
Novel drug target | Established target |
Trial Name | esmirtazapine, ORG-4420 |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | Lu AA24530 |
Mechanism of Interaction | Serotonin 3 (5-HT3) receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3a (5-HT3a) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Serotonin 3 (5-HT3) receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
antagonist (inhibitory) |
Trial Name | olanzapine,Zyprexa, Zypadhera, Zyprexa Relprevv |
Novel drug target | Established target |
Trial Name | Olanzapine/fluoxetine combination,Symbyax (Zyprexa/Prozac) |
HTR3A | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
5-HYDROXYTRYPTAMINE 3 RECEPTOR PRECURSOR (5-HT-3) (SEROTONIN-GATED ION CHANNEL RECEPTOR) (5-HT3R). [SOURCE:UNIPROT/SWISSPROT;ACC:P46098] | Description |
HTR3A | Display Id |
ENSG00000166736 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
HTR4 | Gene Symbol |
HTR3A | Gene Symbol |
Target Class | Receptors |
Target Subclass | GPCR |
Target Subclass | Rhodopsin |
3359 | Entrez Gene Id |
ENSG00000166736 | Ensembl Gene Id |
HTR3A | Uniprot Gene Name |
Interpro Type | Domain |
Interpro Short Name | Neur_chan_lig-bd |
Human Readable Name | DRUGGABLE GENOME |
ION CHANNEL, DRUGGABLE GENOME |
HTR3A | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.9.2.1 |
ENSG00000166736 | Ensembl Gene Id |
P46098 | Uniprot Accession |
5HT3A_HUMAN | Uniprot Id |
Target Subclass | Channels |
Target Subclass | cys-loop |
Target Subclass | Ligand_gated_ion_channels |
PA29555 | PharmGKB ID |
ENSG00000166736 | Gene Symbol |
HTR3A | Ensembl Id |
DRUGGABLE GENOME |
HTR3 | GENE_SYMBOL |
HTR3A | GENE_SYMBOL |
5-hydroxytryptamine receptor 3A | UNIPROT |
HTR3A | TTD Gene Abbreviation |
T64591 | TTD Target ID |
5HT3R | TTD Gene Abbreviation |
T84160 | TTD Target ID |
5-hydroxytryptamine receptor 3A | Gene Name |
P46098 | UniProt ID |
ION CHANNEL |