DGIdb - IL2RB Gene Record

IL2RB 3560 Druggable Genome

Alternate Names:

3560
INTERLEUKIN 2 RECEPTOR SUBUNIT BETA
IL2RB
CD122
IL15RB
P70-75
146710
6009
ENSG00000100385
OTTHUMG00000150534
P14784
IL2RB_HUMAN
IL-2 receptor subunit beta
p75
IL-2RB
IL-2R subunit beta
Interleukin-2 receptor subunit beta
CD_antigen=CD122
High affinity IL-2 receptor subunit beta
Interleukin 2 receptor beta
T19579
IMD63

Gene Info:

Target Class	Receptors
Target Subclass	Receptor
Target Subclass	Type 1 cytokine receptor
Target Main Class	Receptors
Target Subclass	CytokineR
Target Subclass	Type1
Transmembrane Helix Count	1
Target Subclass	IG
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Hausen et al., 2000, Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin., Transplantation
Emparan et al., 2003, Calcineurin-free protocols with basiliximab induction allow patients included in "old to old" programs achieve standard kidney transplant function., Transplant. Proc.
Onrust et al., 1999, Basiliximab., Drugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Schmitz et al., 2002, [Immune suppression by combination therapy with basiliximab and cyclosporin in high risk keratoplasty. A pilot study]., Ophthalmologe
Warlé et al., 2003, Basiliximab interferes with the detection of soluble IL-2 receptor by the Immulite Immunoassay system., J. Immunol. Methods
Duvic et al., 2008, Optimizing denileukin diftitox (Ontak) therapy., Future Oncol
Foss et al., 2005, A phase-1 trial of bexarotene and denileukin diftitox in patients with relapsed or refractory cutaneous T-cell lymphoma., Blood
Foss, 2006, Clinical experience with denileukin diftitox (ONTAK)., Semin. Oncol.
Turturro, 2007, Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders., Expert Rev Anticancer Ther
Lee et al., 2006, Construction and characterization of a novel fusion protein consisting of anti-CD3 antibody fused to recombinant interleukin-2., Oncol. Rep.
Steppan et al., 2006, Reduced secondary cytokine induction by BAY 50-4798, a high-affinity receptor-specific interleukin-2 analog., J. Interferon Cytokine Res.
Stauber et al., 2006, Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor., Proc. Natl. Acad. Sci. U.S.A.
Maclennan et al., 2006, Airway inflammation in asymptomatic children with episodic wheeze., Pediatr. Pulmonol.
Cornish et al., 2006, Differential regulation of T-cell growth by IL-2 and IL-15., Blood
Forrest et al., 2005, Daclizumab therapy in kidney transplantation-different mechanisms of action in- versus ex-vivo?, Transpl. Immunol.
Aguillón et al., 2003, [New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies]., Rev Med Chil
Light et al., 2002, Daclizumab induction/tacrolimus sparing: a randomized prospective trial in renal transplantation., Clin Transplant
Ramos et al., 1989, Differential IL-2 receptor expression in renal allograft recipients treated with an anti-IL-2-receptor antibody., Transplantation
Burkhardt et al., 1989, Anti-IL-2 receptor monoclonal antibody AMT-13 increases soluble IL-2 receptor levels in vivo., Immunology

BASILIXIMAB IL2RB

Interaction Score: 28.85

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
10708100 12826150 10188761 11752352 11840795 12667677

Sources:
ChemblInteractions
ALDESLEUKIN IL2RB

Interaction Score: 27.82

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor agonist

Direct Interaction yes

Trial Name Proleukin IL-2

PMIDs:
16596189 16542139 16477002 16617454 11752352 16569767

Sources:
TdgClinicalTrial ChemblInteractions TEND
DACLIZUMAB IL2RB

Interaction Score: 21.64

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
15814281 15022409 12372041 2571203 11752352 2647626

Sources:
ChemblInteractions
DENILEUKIN DIFTITOX IL2RB

Interaction Score: 18.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor binding agent

Direct Interaction yes

PMIDs:
18684057 15811959 16516670 11752352 17187516

Sources:
ChemblInteractions
ALDESLEUKIN IL2RB

Interaction Score: 0.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name IRX-2

PMIDs:
None found

Sources:
TdgClinicalTrial

Ensembl: ENSG00000100385
- Version: 101_38
Alternate Names:

IL2RB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P14784
- Version: 01-August-2011
Alternate Names:

P14784 Uniprot Accession

3560 Entrez Gene Id

IL2RB Gene Symbol

Gene Info:

Target Main Class Receptors

Target Subclass CytokineR

Target Subclass Type1

Publications:
TdgClinicalTrial: P14784
- Version: January-2014
Alternate Names:

IL2RB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Publications:
HingoraniCasas: ENSG00000100385
- Version: 31-May-2017
Alternate Names:

ENSG00000100385 Gene Symbol

IL2RB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: IL2RB
- Version: chembl_23
Alternate Names:

IL2RB GENE_SYMBOL

Interleukin-2 receptor subunit beta UNIPROT

High affinity IL-2 receptor subunit beta UNIPROT

Gene Info:

Publications:
GO: IL2RB
- Version: 01-February-2022
Alternate Names:

IL15RB GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
TTD: Interleukin 2 receptor beta
- Version: 2020.06.01
Alternate Names:

IL2RB TTD Gene Abbreviation

T19579 TTD Target ID

Gene Info:

Publications:

Mechanism of Interaction	Interleukin-2 receptor inhibitor
Direct Interaction	yes

Mechanism of Interaction	Interleukin-2 receptor agonist
Direct Interaction	yes
Trial Name	Proleukin IL-2

Mechanism of Interaction	Interleukin-2 receptor binding agent
Direct Interaction	yes

IL2RB	GENE_SYMBOL
Interleukin-2 receptor subunit beta	UNIPROT
High affinity IL-2 receptor subunit beta	UNIPROT

antibody (inhibitory)
inhibitor (inhibitory)

agonist (activating)
modulator

antibody (inhibitory)
inhibitor (inhibitory)

Novel drug target	Established target
Trial Name	IRX-2

IL2RB Gene Record

IL2RB 3560 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

BASILIXIMAB IL2RB

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor inhibitor Direct Interaction yes

PMIDs: 10708100 12826150 10188761 11752352 11840795 12667677

Sources: ChemblInteractions

ALDESLEUKIN IL2RB

Interaction Types & Directionality: agonist (activating) modulator

Interaction Info: Mechanism of Interaction Interleukin-2 receptor agonist Direct Interaction yes Trial Name Proleukin IL-2

PMIDs: 16596189 16542139 16477002 16617454 11752352 16569767

Sources: TdgClinicalTrial ChemblInteractions TEND

DACLIZUMAB IL2RB

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor inhibitor Direct Interaction yes

PMIDs: 15814281 15022409 12372041 2571203 11752352 2647626

Sources: ChemblInteractions

DENILEUKIN DIFTITOX IL2RB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor binding agent Direct Interaction yes

PMIDs: 18684057 15811959 16516670 11752352 17187516

Sources: ChemblInteractions

ALDESLEUKIN IL2RB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name IRX-2

PMIDs: None found

Sources: TdgClinicalTrial

Ensembl: ENSG00000100385

Alternate Names: IL2RB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TEND: P14784

Alternate Names: P14784 Uniprot Accession 3560 Entrez Gene Id IL2RB Gene Symbol

Gene Info: Target Main Class Receptors Target Subclass CytokineR Target Subclass Type1

Publications:

TdgClinicalTrial: P14784

Alternate Names: IL2RB Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptor Target Subclass Type 1 cytokine receptor

Publications:

HingoraniCasas: ENSG00000100385

Alternate Names: ENSG00000100385 Gene Symbol IL2RB Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: IL2RB

Alternate Names: IL2RB GENE_SYMBOL Interleukin-2 receptor subunit beta UNIPROT High affinity IL-2 receptor subunit beta UNIPROT

Gene Info:

Publications:

GO: IL2RB

Alternate Names: IL15RB GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

TTD: Interleukin 2 receptor beta

Alternate Names: IL2RB TTD Gene Abbreviation T19579 TTD Target ID

Gene Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
10708100 12826150 10188761 11752352 11840795 12667677

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

modulator

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor agonist

Direct Interaction yes

Trial Name Proleukin IL-2

PMIDs:
16596189 16542139 16477002 16617454 11752352 16569767

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
15814281 15022409 12372041 2571203 11752352 2647626

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor binding agent

Direct Interaction yes

PMIDs:
18684057 15811959 16516670 11752352 17187516

Sources:
ChemblInteractions

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name IRX-2

PMIDs:
None found

Sources:
TdgClinicalTrial

Alternate Names:

IL2RB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

P14784 Uniprot Accession

3560 Entrez Gene Id

IL2RB Gene Symbol

Gene Info:

Target Main Class Receptors

Target Subclass CytokineR

Target Subclass Type1

Alternate Names:

IL2RB Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptor

Target Subclass Type 1 cytokine receptor

Alternate Names:

ENSG00000100385 Gene Symbol

IL2RB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

IL2RB GENE_SYMBOL

Interleukin-2 receptor subunit beta UNIPROT

High affinity IL-2 receptor subunit beta UNIPROT

Alternate Names:

IL15RB GO Gene Synonym

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Alternate Names:

IL2RB TTD Gene Abbreviation

T19579 TTD Target ID