DGIdb - BASILIXIMAB Drug Record

BASILIXIMAB chembl:CHEMBL1201439 ApprovedImmunotherapy

Alternate Names:

SIMULECT
BASILIXIMAB
CHI-621
SDZ-CHI-621
CHI621
CHIMERIC MOUSE-HUMAN ANTICD25
IG GAMMA-1 CHAIN C REGION
chembl:CHEMBL1201439
chemidplus:179045-86-4
drugbank:00074
rxcui:196102

Drug Info:

FDA Approval	approved
Drug Class	monoclonal antibody
Drug Indications	immunomodulatory agent
Drug Class	immunosuppressive agents
Year of Approval	1998

(1 More Sources)

Publications:

Kovarik et al., 1998, Disposition and immunodynamics of basiliximab in liver allograft recipients., Clin. Pharmacol. Ther.
Berard et al., 1999, A review of interleukin-2 receptor antagonists in solid organ transplantation., Pharmacotherapy
Choy et al., 2003, IL2-receptor antagonist (basiliximab) induction therapy is associated with lower morbidity and mortality in renal transplant recipients., Transplant. Proc.
Garcia et al., Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis., Transplant. Proc.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Mentré et al., 1999, Constructing a prediction interval for time to reach a threshold concentration based on a population pharmacokinetic analysis: an application to basiliximab in renal transplantation., J Pharmacokinet Biopharm
Hausen et al., 2000, Prevention of acute allograft rejection in nonhuman primate lung transplant recipients: induction with chimeric anti-interleukin-2 receptor monoclonal antibody improves the tolerability and potentiates the immunosuppressive activity of a regimen using low doses of both microemulsion cyclosporine and 40-O-(2-hydroxyethyl)-rapamycin., Transplantation
Emparan et al., 2003, Calcineurin-free protocols with basiliximab induction allow patients included in "old to old" programs achieve standard kidney transplant function., Transplant. Proc.
Onrust et al., 1999, Basiliximab., Drugs
Schmitz et al., 2002, [Immune suppression by combination therapy with basiliximab and cyclosporin in high risk keratoplasty. A pilot study]., Ophthalmologe
Warlé et al., 2003, Basiliximab interferes with the detection of soluble IL-2 receptor by the Immulite Immunoassay system., J. Immunol. Methods

BASILIXIMAB IL2RB

Interaction Score: 28.85

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
10708100 12826150 10188761 11752352 11840795 12667677

Sources:
ChemblInteractions
BASILIXIMAB IL2RA

Interaction Score: 7.11

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

Trial Name basiliximab,Simulect

PMIDs:
9695721 10512062 12591363 16908318 11752352 10567956

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
BASILIXIMAB IL2RG

Interaction Score: 4.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TEND: BASILIXIMAB
- Version: 01-August-2011
Alternate Names:

BASILIXIMAB Primary Drug Name

Drug Info:

Year of Approval 1998

Drug Class immunosuppressive agents

Publications:
TdgClinicalTrial: BASILIXIMAB
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications immunomodulatory agent

Drug Class monoclonal antibody

FDA Approval approved

Publications:
TTD: Basiliximab
- Version: 2020.06.01
Alternate Names:

D06SBB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201439
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201439
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Interleukin-2 receptor inhibitor
Direct Interaction	yes

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

BASILIXIMAB Drug Record

BASILIXIMAB chembl:CHEMBL1201439 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

BASILIXIMAB IL2RB

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor inhibitor Direct Interaction yes

PMIDs: 10708100 12826150 10188761 11752352 11840795 12667677

Sources: ChemblInteractions

BASILIXIMAB IL2RA

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor inhibitor Direct Interaction yes Trial Name basiliximab,Simulect

PMIDs: 9695721 10512062 12591363 16908318 11752352 10567956

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

BASILIXIMAB IL2RG

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Interleukin-2 receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TEND: BASILIXIMAB

Alternate Names: BASILIXIMAB Primary Drug Name

Drug Info: Year of Approval 1998 Drug Class immunosuppressive agents

Publications:

TdgClinicalTrial: BASILIXIMAB

Alternate Names:

Drug Info: Drug Indications immunomodulatory agent Drug Class monoclonal antibody FDA Approval approved

Publications:

TTD: Basiliximab

Alternate Names: D06SBB TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201439

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201439

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
10708100 12826150 10188761 11752352 11840795 12667677

Sources:
ChemblInteractions

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

Trial Name basiliximab,Simulect

PMIDs:
9695721 10512062 12591363 16908318 11752352 10567956

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Interleukin-2 receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

BASILIXIMAB Primary Drug Name

Drug Info:

Year of Approval 1998

Drug Class immunosuppressive agents

Drug Info:

Drug Indications immunomodulatory agent

Drug Class monoclonal antibody

FDA Approval approved

Alternate Names:

D06SBB TTD Drug ID