DGIdb - PRKCB Gene Record

PRKCB 5579 Druggable GenomeClinically Actionable

Alternate Names:

5579
PROTEIN KINASE C BETA
PRKCB
PKC-beta
PKCB
PRKCB1
PRKCB2
176970
9395
ENSG00000166501
OTTHUMG00000131615
PKC-B
Protein kinase C beta type
PROTEIN KINASE C, BETA TYPE (EC 2.7.1.37) (PKC-BETA) (PKC-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P05771]
PKC
P05771
KPCB_HUMAN
PA33761
T40276
PKCI(2)
PKCbeta

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Acc	IPR002290
Uniprot Status	Swiss-Prot
Human Readable Name	KINASE
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Initial Gene Query	PKC beta
Counted Citations from 1950-2000	908
Target Class	Enzymes
Target Subclass	EC:2.7.11.13
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

TRANSPORTER
KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett
Abdel-Halim M et al., 2014, Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ., J Med Chem
Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett

RUBOXISTAURIN PRKCB

Interaction Score: 4.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Trial Name ruboxistaurin mesylate, LY 333531,Arxxant

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ENZASTAURIN PRKCB

Interaction Score: 2.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD
BISINDOLYLMALEIMIDE IX PRKCB

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25058929

Sources:
DTC
BRYOSTATIN PRKCB

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial
ENOXOLONE PRKCB

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24461294

Sources:
DTC
DEXMEDETOMIDINE PRKCB

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
CEP-2563 PRKCB

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GSK-690693 PRKCB

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
UCN-01 PRKCB

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MIDOSTAURIN PRKCB

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ATENOLOL PRKCB

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SOTRASTAURIN PRKCB

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
QUERCETIN PRKCB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome

Ensembl: ENSG00000166501
- Version: 101_38
Alternate Names:

PRKCB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000166501
- Version: 26-July-2011
Alternate Names:

PROTEIN KINASE C, BETA TYPE (EC 2.7.1.37) (PKC-BETA) (PKC-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P05771] Description

ENSG00000166501 Ensembl Gene Id

PRKCB1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P05771
- Version: January-2014
Alternate Names:

PRKCB Gene Symbol

PRKCB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Publications:
HopkinsGroom: P05771
- Version: 11-September-2012
Alternate Names:

PRKCB Uniprot Gene Name

PROTEIN KINASE C BETA TYPE Uniprot Protein Name

KPCB_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002290

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
BaderLabGenes: PRKCB
- Version: February-2014
Alternate Names:

5579 Entrez Gene ID

Gene Info:

Initial Gene Query PKC beta

Counted Citations from 1950-2000 908

Gene Categories:

KINASE

Publications:

DTC: PRKCB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Abdel-Halim M et al., 2014, Discovery and optimization of 1,3,5-trisubstituted pyrazolines as potent and highly selective allosteric inhibitors of protein kinase C-ζ., J Med Chem

Song J et al., 2014, Inhibition of protein kinase C α/βII and activation of c-Jun NH2-terminal kinase mediate glycyrrhetinic acid induced apoptosis in non-small cell lung cancer NCI-H460 cells., Bioorg Med Chem Lett

Keck GE et al., 2012, Role of the C8 gem-dimethyl group of bryostatin 1 on its unique pattern of biological activity., Bioorg Med Chem Lett

HingoraniCasas: ENSG00000166501
- Version: 31-May-2017
Alternate Names:

ENSG00000166501 Gene Symbol

PRKCB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: PKCB
- Version: 12-May-2016
Alternate Names:

PKCB Gene Symbol

Gene Info:

Publications:
MyCancerGenome: PRKCB
- Version: 20-Jun-2017
Alternate Names:

5579 Entrez Gene Id

PRKCB MyCancerGenome Gene Symbol

PKC-beta MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: PKCB
- Version: chembl_23
Alternate Names:

PRKCB1 GENE_SYMBOL

PRKCB GENE_SYMBOL

Protein kinase C beta type UNIPROT

Gene Info:

Publications:
PharmGKB: PRKCB
- Version: 18-August-2020
Alternate Names:

PA33761 PharmGKB ID

Gene Info:

Publications:
GO: PRKCB
- Version: 01-February-2022
Alternate Names:

PKCB GO Gene Synonym

PRKCB1 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: PRKCB
- Version: 27-Jun-2013
Alternate Names:

5579 Gene ID

PKC-beta dGene Synonym

PKCB dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Protein kinase C beta
- Version: 2020.06.01
Alternate Names:

PRKCB TTD Gene Abbreviation

T40276 TTD Target ID

Gene Info:

Publications:
Pharos: PRKCB
- Version: 01-February-2022
Alternate Names:

Protein kinase C beta type Gene Name

P05771 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER, KINASE

Publications:
CarisMolecularIntelligence: PRKCB
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Protein kinase C beta inhibitor
Direct Interaction	yes
Trial Name	ruboxistaurin mesylate, LY 333531,Arxxant

Mechanism of Interaction	Protein kinase C (PKC) inhibitor
Direct Interaction	yes

PROTEIN KINASE C, BETA TYPE (EC 2.7.1.37) (PKC-BETA) (PKC-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P05771]	Description
ENSG00000166501	Ensembl Gene Id
PRKCB1	Display Id

PRKCB	Uniprot Gene Name
PROTEIN KINASE C BETA TYPE	Uniprot Protein Name
KPCB_HUMAN	Uniprot Id

5579	Entrez Gene Id
PRKCB	MyCancerGenome Gene Symbol
PKC-beta	MyCancerGenome Reported Gene Name

PRKCB1	GENE_SYMBOL
PRKCB	GENE_SYMBOL
Protein kinase C beta type	UNIPROT

Trial Name	Bryostatin
Novel drug target	Established target

PRKCB Gene Record

PRKCB 5579 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C beta inhibitor Direct Interaction yes Trial Name ruboxistaurin mesylate, LY 333531,Arxxant

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C beta inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25058929

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Bryostatin Novel drug target Established target

PMIDs: 22579485

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24461294

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C (PKC) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Ensembl: ENSG00000166501

Alternate Names: PRKCB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000166501

Alternate Names: PROTEIN KINASE C, BETA TYPE (EC 2.7.1.37) (PKC-BETA) (PKC-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P05771] Description ENSG00000166501 Ensembl Gene Id PRKCB1 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P05771

Alternate Names: PRKCB Gene Symbol PRKCB1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.11.13

Publications:

HopkinsGroom: P05771

Alternate Names: PRKCB Uniprot Gene Name PROTEIN KINASE C BETA TYPE Uniprot Protein Name KPCB_HUMAN Uniprot Id

Gene Info: Interpro Acc IPR002290 Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

BaderLabGenes: PRKCB

Alternate Names: 5579 Entrez Gene ID

Gene Info: Initial Gene Query PKC beta Counted Citations from 1950-2000 908

Gene Categories: KINASE

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Trial Name ruboxistaurin mesylate, LY 333531,Arxxant

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
25058929

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Bryostatin

Novel drug target Established target

PMIDs:
22579485

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
24461294

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Protein kinase C (PKC) inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C (PKC) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Alternate Names:

PRKCB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PROTEIN KINASE C, BETA TYPE (EC 2.7.1.37) (PKC-BETA) (PKC-B). [SOURCE:UNIPROT/SWISSPROT;ACC:P05771] Description

ENSG00000166501 Ensembl Gene Id

PRKCB1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PRKCB Gene Symbol

PRKCB1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.11.13

Alternate Names:

PRKCB Uniprot Gene Name

PROTEIN KINASE C BETA TYPE Uniprot Protein Name

KPCB_HUMAN Uniprot Id

Gene Info:

Interpro Acc IPR002290

Uniprot Status Swiss-Prot

Human Readable Name DRUGGABLE GENOME

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

5579 Entrez Gene ID

Gene Info:

Initial Gene Query PKC beta

Counted Citations from 1950-2000 908

Gene Categories:

KINASE

Alternate Names:

ENSG00000166501 Gene Symbol

PRKCB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PKCB Gene Symbol

Alternate Names:

5579 Entrez Gene Id

PRKCB MyCancerGenome Gene Symbol

PKC-beta MyCancerGenome Reported Gene Name

Alternate Names:

PRKCB1 GENE_SYMBOL

PRKCB GENE_SYMBOL

Protein kinase C beta type UNIPROT

Alternate Names:

PA33761 PharmGKB ID

Alternate Names:

PKCB GO Gene Synonym

PRKCB1 GO Gene Synonym

Gene Categories:

SERINE THREONINE KINASE

Alternate Names:

5579 Gene ID

PKC-beta dGene Synonym

PKCB dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

PRKCB TTD Gene Abbreviation

T40276 TTD Target ID

Alternate Names:

Protein kinase C beta type Gene Name

P05771 UniProt ID

Gene Categories:

TRANSPORTER, KINASE

Gene Categories:

CLINICALLY ACTIONABLE