DGIdb - RRM2B Gene Record

RRM2B 50484 Druggable Genome

Alternate Names:

50484
RIBONUCLEOTIDE REDUCTASE REGULATORY TP53 INDUCIBLE SUBUNIT M2B
RRM2B
MTDPS8A
MTDPS8B
P53R2
604712
17296
ENSG00000048392
OTTHUMG00000164776
Q7LG56
p53-inducible ribonucleotide reductase small subunit 2-like protein
TP53-inducible ribonucleotide reductase M2 B
Ribonucleoside-diphosphate reductase subunit M2 B
PA34866

Gene Info:

Target Class	Enzymes
Target Subclass	EC:1.17.4.1
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

DNA REPAIR
DRUGGABLE GENOME
ENZYME

Publications:

Sampat et al., 2009, Clofarabine: emerging role in leukemias., Expert Opin Investig Drugs
Kantarjian et al., 2007, Clofarabine: past, present, and future., Leuk. Lymphoma
Zhenchuk et al., 2009, Mechanisms of anti-cancer action and pharmacology of clofarabine., Biochem. Pharmacol.
Takahashi et al., 1999, Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration., Cancer Chemother. Pharmacol.
Kline et al., 2005, Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review., Expert Opin Pharmacother
Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics

CLADRIBINE RRM2B

Interaction Score: 3.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19715446 17852710 19576186 9923554 16316309 24024897

Sources:
PharmGKB
TEZACITABINE RRM2B

Interaction Score: 2.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GALLIUM NITRATE RRM2B

Interaction Score: 2.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FLUDARABINE PHOSPHATE RRM2B

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
GEMCITABINE HYDROCHLORIDE RRM2B

Interaction Score: 0.98

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOFARABINE RRM2B

Interaction Score: 0.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYUREA RRM2B

Interaction Score: 0.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CYTARABINE RRM2B

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24024897

Sources:
PharmGKB
GEMCITABINE RRM2B

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Ensembl: ENSG00000048392
- Version: 101_38
Alternate Names:

RRM2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q7LG56
- Version: January-2014
Alternate Names:

RRM2B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.4.1

Publications:
PharmGKB: RRM2B
- Version: 18-August-2020
Alternate Names:

PA34866 PharmGKB ID

Gene Info:

Publications:

Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics
HingoraniCasas: ENSG00000048392
- Version: 31-May-2017
Alternate Names:

ENSG00000048392 Gene Symbol

RRM2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: P53R2
- Version: chembl_23
Alternate Names:

P53R2 GENE_SYMBOL

RRM2B GENE_SYMBOL

Ribonucleoside-diphosphate reductase subunit M2 B UNIPROT

Gene Info:

Publications:
GO: RRM2B
- Version: 01-February-2022
Alternate Names:

P53R2 GO Gene Synonym

Gene Info:

Gene Categories:

DNA REPAIR

Publications:
Pharos: RRM2B
- Version: 01-February-2022
Alternate Names:

Ribonucleoside-diphosphate reductase subunit M2 B Gene Name

Q7LG56 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
ClearityFoundationClinicalTrial: RRM2B
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:

Mechanism of Interaction	Ribonucleoside-diphosphate reductase RR1 inhibitor
Direct Interaction	yes

P53R2	GENE_SYMBOL
RRM2B	GENE_SYMBOL
Ribonucleoside-diphosphate reductase subunit M2 B	UNIPROT

Ribonucleoside-diphosphate reductase subunit M2 B	Gene Name
Q7LG56	UniProt ID

RRM2B Gene Record

RRM2B 50484 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19715446 17852710 19576186 9923554 16316309 24024897

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24024897

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Ensembl: ENSG00000048392

Alternate Names: RRM2B Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q7LG56

Alternate Names: RRM2B Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:1.17.4.1

Publications:

PharmGKB: RRM2B

Alternate Names: PA34866 PharmGKB ID

Gene Info:

Publications: Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics

HingoraniCasas: ENSG00000048392

Alternate Names: ENSG00000048392 Gene Symbol RRM2B Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: P53R2

Alternate Names: P53R2 GENE_SYMBOL RRM2B GENE_SYMBOL Ribonucleoside-diphosphate reductase subunit M2 B UNIPROT

Gene Info:

Publications:

GO: RRM2B

Alternate Names: P53R2 GO Gene Synonym

Gene Info:

Gene Categories: DNA REPAIR

Publications:

Pharos: RRM2B

Alternate Names: Ribonucleoside-diphosphate reductase subunit M2 B Gene Name Q7LG56 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

ClearityFoundationClinicalTrial: RRM2B

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19715446 17852710 19576186 9923554 16316309 24024897

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
24024897

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Alternate Names:

RRM2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

RRM2B Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.4.1

Alternate Names:

PA34866 PharmGKB ID

Publications:

Cao X et al., 2013, RRM1 and RRM2 pharmacogenetics: association with phenotypes in HapMap cell lines and acute myeloid leukemia patients., Pharmacogenomics

Alternate Names:

ENSG00000048392 Gene Symbol

RRM2B Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

P53R2 GENE_SYMBOL

RRM2B GENE_SYMBOL

Ribonucleoside-diphosphate reductase subunit M2 B UNIPROT

Alternate Names:

P53R2 GO Gene Synonym

Gene Categories:

DNA REPAIR

Alternate Names:

Ribonucleoside-diphosphate reductase subunit M2 B Gene Name

Q7LG56 UniProt ID

Gene Categories:

ENZYME