DGIdb - CLOFARABINE Drug Record

CLOFARABINE chembl:CHEMBL1750 ApprovedAntineoplasticImmunotherapy

Alternate Names:

CLOFARABINE
CLOLAR
EVOLTRA
CLOFARABINUM
2-CHLORO-9-(2'-DEOXY-2'-FLUORO-BETA-D-ARABINOFURANOSYL)ADENINE
CL-F-ARA-A
(2R,3R,4S,5R)-5-(6-AMINO-2-CHLOROPURIN-9-YL)-4-FLUORO-2-(HYDROXYMETHYL)OXOLAN-3-OL
CL-F-ARAA
2-CHLORO-9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)ADENINE
CLOFARABIN
CLOFARABINA
CLOLAR®
EVOLTRA®
CLOFAREX
CAFDA
chembl:CHEMBL1750
chemidplus:123318-82-1
pubchem.compound:119182
drugbank:00631
rxcui:44151

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antineoplastic agent
Drug Class	antineoplastic agents
Year of Approval	2004

(3 More Sources)

Publications:

2004, Clofarabine., Drugs R D
Kantarjian et al., 2007, Clofarabine: past, present, and future., Leuk. Lymphoma
Harned et al., 2008, Treating refractory leukemias in childhood, role of clofarabine., Ther Clin Risk Manag
Pession et al., 2010, Use of clofarabine for acute childhood leukemia., Biologics
Zhenchuk et al., 2009, Mechanisms of anti-cancer action and pharmacology of clofarabine., Biochem. Pharmacol.
Lech-Maranda et al., 2009, Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity., Mini Rev Med Chem
Musto et al., 2008, Clofarabine: in search of combinations for the treatment of patients with high-risk acute myeloid leukemia., Cancer
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

CLOFARABINE POLA1

Interaction Score: 11.78

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
CLOFARABINE RRM1

Interaction Score: 5.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
CLOFARABINE APBB1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CLOFARABINE POLD1

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOFARABINE POLE

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOFARABINE RRM2B

Interaction Score: 0.76

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CLOFARABINE RRM2

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CLOFARABINE FLT3

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
CLOFARABINE AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: CLOFARABINE
- Version: 01-August-2011
Alternate Names:

CLOFARABINE Primary Drug Name

Drug Info:

Year of Approval 2004

Drug Class antineoplastic agents

Publications:
TdgClinicalTrial: CLOFARABINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: CLOFARABINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1750 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Clofarabine
- Version: 2020.06.01
Alternate Names:

D0R5RR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1750
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: CLOFARABINE
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1750
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	Clofarabine
Mechanism of Interaction	DNA polymerase (alpha/delta/epsilon) inhibitor

Mechanism of Interaction	DNA polymerase (alpha/delta/epsilon) inhibitor
Direct Interaction	yes

Mechanism of Interaction	Ribonucleoside-diphosphate reductase RR1 inhibitor
Direct Interaction	yes

CLOFARABINE Drug Record

CLOFARABINE chembl:CHEMBL1750 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Clofarabine Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

PMIDs: 15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name Clofarabine Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: 15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenomeClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: CLOFARABINE

Alternate Names: CLOFARABINE Primary Drug Name

Drug Info: Year of Approval 2004 Drug Class antineoplastic agents

Publications:

TdgClinicalTrial: CLOFARABINE

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small Molecule FDA Approval approved

Publications:

DTC: CLOFARABINE

Alternate Names: CHEMBL1750 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Clofarabine

Alternate Names: D0R5RR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1750

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: CLOFARABINE

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1750

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Clofarabine

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
15230627 17852710 18728851 20631817 19576186 19519505 18780321 17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction DNA polymerase (alpha/delta/epsilon) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Ribonucleoside-diphosphate reductase RR1 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

CLOFARABINE Primary Drug Name

Drug Info:

Year of Approval 2004

Drug Class antineoplastic agents

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1750 ChEMBL Drug ID

Alternate Names:

D0R5RR TTD Drug ID