DGIdb - TYK2 Gene Record

TYK2 7297 Druggable GenomeClinically Actionable

Alternate Names:

7297
TYROSINE KINASE 2
TYK2
IMD35
JTK1
176941
12440
ENSG00000105397
OTTHUMG00000166373
Non-receptor tyrosine-protein kinase TYK2
P29597
TYK2_HUMAN
NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P29597]
TYK2 tyrosine kinase
T78932

Gene Info:

Uniprot Status	Swiss-Prot
Interpro Type	Domain
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Human Readable Name	KINASE
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR001245
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(10 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Jang WD et al., 2015, Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design., Bioorg Med Chem Lett
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Malerich et al., 2010, Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3., Bioorg. Med. Chem. Lett.
Bacon et al., 1995, Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12., J. Exp. Med.

BREPOCITINIB TYK2

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOFACITINIB TYK2

Interaction Score: 1.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26231159 10592235

Sources:
DTC
TOFACITINIB CITRATE TYK2

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CERDULATINIB TYK2

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase TYK2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PEFICITINIB TYK2

Interaction Score: 0.62

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AT-9283 TYK2

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
ALDESLEUKIN TYK2

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7528775

Sources:
NCI
JNJ-7706621 TYK2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21106455

Sources:
DTC
HESPERADIN TYK2

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
GO-6976 TYK2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOZASERTIB TYK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
R-406 TYK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 TYK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB TYK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB TYK2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000105397
- Version: 101_38
Alternate Names:

TYK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P29597
- Version: 11-September-2012
Alternate Names:

ENSG00000105397 Ensembl Gene Id

TYK2_HUMAN Uniprot Id

7297 Entrez Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000105397
- Version: 26-July-2011
Alternate Names:

NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P29597] Description

TYK2 Display Id

ENSG00000105397 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: TYK2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Prabhakar et al., 2005, IFN-alpha beta secreted during infection is necessary but not sufficient for negative feedback regulation of IFN-alpha beta signaling by Mycobacterium tuberculosis., J. Immunol.

Sigurdsson et al., 2005, Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus., Am. J. Hum. Genet.

Bacon et al., 1995, Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12., J. Exp. Med.

DTC: TYK2

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Malerich et al., 2010, Diamino-1,2,4-triazole derivatives are selective inhibitors of TYK2 and JAK1 over JAK2 and JAK3., Bioorg. Med. Chem. Lett.

Jang WD et al., 2015, Discovery of Tyk2 inhibitors via the virtual site-directed fragment-based drug design., Bioorg Med Chem Lett

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

HingoraniCasas: ENSG00000105397
- Version: 31-May-2017
Alternate Names:

ENSG00000105397 Gene Symbol

TYK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: TYK2
- Version: 12-May-2016
Alternate Names:

TYK2 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: TYK2
- Version: chembl_23
Alternate Names:

TYK2 GENE_SYMBOL

Non-receptor tyrosine-protein kinase TYK2 UNIPROT

Gene Info:

Publications:
HumanProteinAtlas: TYK2
- Version: 19.3
Alternate Names:

ENSG00000105397 Ensembl Gene ID

JTK1 Human Protein Atlas Gene Synonym

Tyrosine kinase 2 Human Protein Atlas Gene Description

Gene Info:

Gene Categories:

ENZYME

Publications:
dGene: TYK2
- Version: 27-Jun-2013
Alternate Names:

7297 Gene ID

JTK1 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: TYK2 tyrosine kinase
- Version: 2020.06.01
Alternate Names:

TYK2 TTD Gene Abbreviation

T78932 TTD Target ID

Gene Info:

Publications:
Pharos: TYK2
- Version: 01-February-2022
Alternate Names:

Non-receptor tyrosine-protein kinase TYK2 Gene Name

P29597 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
FoundationOneGenes: TYK2
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: TYK2
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

TYROSINE KINASE

Publications:

Mechanism of Interaction	Janus Kinase (JAK) inhibitor
Direct Interaction	yes

Mechanism of Interaction	Tyrosine-protein kinase TYK2 inhibitor
Direct Interaction	yes

ENSG00000105397	Ensembl Gene Id
TYK2_HUMAN	Uniprot Id
7297	Entrez Gene Id

NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P29597]	Description
TYK2	Display Id
ENSG00000105397	Ensembl Gene Id

TYK2	GENE_SYMBOL
Non-receptor tyrosine-protein kinase TYK2	UNIPROT

Non-receptor tyrosine-protein kinase TYK2	Gene Name
P29597	UniProt ID

TYK2 Gene Record

TYK2 7297 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26231159 10592235

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tyrosine-protein kinase TYK2 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Janus Kinase (JAK) inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7528775

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21106455

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26231159 10592235

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tyrosine-protein kinase TYK2 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Janus Kinase (JAK) inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Interaction Types & Directionality:

n/a

PMIDs:
7528775

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21106455

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

TYK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000105397 Ensembl Gene Id

TYK2_HUMAN Uniprot Id

7297 Entrez Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Type Domain

Interpro Name Serine-threonine/tyrosine-protein kinase catalytic domain

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P29597] Description

TYK2 Display Id

ENSG00000105397 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000105397 Gene Symbol

TYK2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TYK2 Gene Symbol

Alternate Names:

TYK2 GENE_SYMBOL

Non-receptor tyrosine-protein kinase TYK2 UNIPROT

Alternate Names:

ENSG00000105397 Ensembl Gene ID

JTK1 Human Protein Atlas Gene Synonym

Tyrosine kinase 2 Human Protein Atlas Gene Description

Gene Categories:

ENZYME

Alternate Names:

7297 Gene ID

JTK1 dGene Synonym

Gene Categories:

KINASE, TYROSINE KINASE