DGIdb - ADINAZOLAM Drug Record

ADINAZOLAM chembl:CHEMBL328250

Alternate Names:

U-41123
ADINAZOLAM
ADINAZOLAMUM
8-CHLORO-1-((DIMETHYLAMINO)METHYL)-6-PHENYL-4H-S-TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE
chemidplus:37115-32-5
drugbank:00546
pubchem.compound:37632
chembl:CHEMBL328250

Drug Info:

Drug Class	anticonvulsant
Year of Approval	not approved by the fda
Drug Class	anti-anxiety agents
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	anticonvulsant
Drug Indications	Anti-anxiety Agents

(0 More Sources)

Publications:

Lahti et al., 1983, Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine., Neuropharmacology
Sethy et al., 1984, Determination of biological activity of adinazolam and its metabolites., J. Pharm. Pharmacol.
Zhu S et al., 2018, Structure of a human synaptic GABA<sub>A</sub> receptor., Nature
Sigel E et al., 2012, Structure, function, and modulation of GABA(A) receptors., J Biol Chem

ADINAZOLAM GABRR3

Interaction Score: 0.58

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRR2

Interaction Score: 0.58

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRR1

Interaction Score: 0.54

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRE

Interaction Score: 0.24

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRP

Interaction Score: 0.24

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRA1

Interaction Score: 0.24

Interaction Types & Directionality:

ligand

positive modulator (activating)

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400 29950725 23038269

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRD

Interaction Score: 0.24

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRB3

Interaction Score: 0.23

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRG1

Interaction Score: 0.23

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRB1

Interaction Score: 0.23

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRB2

Interaction Score: 0.21

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRG3

Interaction Score: 0.2

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRA5

Interaction Score: 0.2

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRA3

Interaction Score: 0.19

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRA2

Interaction Score: 0.19

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND
ADINAZOLAM GABRG2

Interaction Score: 0.17

Interaction Types & Directionality:

potentiator

Interaction Info:

PMIDs:
6320036 6148400

Sources:
TEND
ADINAZOLAM TSPO

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: ADINAZOLAM
- Version: 01-August-2011
Alternate Names:

ADINAZOLAM Primary Drug Name

Drug Info:

Drug Class anti-anxiety agents

Year of Approval not approved by the fda

Drug Class anticonvulsant

Publications:
TdgClinicalTrial: ADINAZOLAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-anxiety Agents

Drug Indications anticonvulsant

Drug Class small molecule

Publications:
TTD: Adinazolam
- Version: 2020.06.01
Alternate Names:

D0E7FS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL328250
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

ADINAZOLAM Drug Record

ADINAZOLAM chembl:CHEMBL328250

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: ligand positive modulator (activating) potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6320036 6148400 29950725 23038269

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 6320036 6148400

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: potentiator

Interaction Info:

PMIDs: 6320036 6148400

Sources: TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: ADINAZOLAM

Alternate Names: ADINAZOLAM Primary Drug Name

Drug Info: Drug Class anti-anxiety agents Year of Approval not approved by the fda Drug Class anticonvulsant

Publications:

TdgClinicalTrial: ADINAZOLAM

Alternate Names:

Drug Info: Drug Indications Anti-anxiety Agents Drug Indications anticonvulsant Drug Class small molecule

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

ligand

positive modulator (activating)

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400 29950725 23038269

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
6320036 6148400

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

potentiator

PMIDs:
6320036 6148400

Sources:
TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

ADINAZOLAM Primary Drug Name

Drug Info:

Drug Class anti-anxiety agents

Year of Approval not approved by the fda

Drug Class anticonvulsant

Drug Info:

Drug Indications Anti-anxiety Agents

Drug Indications anticonvulsant

Drug Class small molecule

Alternate Names:

D0E7FS TTD Drug ID