DGIdb - CHLORPROPAMIDE Drug Record

CHLORPROPAMIDE chembl:CHEMBL498 Approved

Alternate Names:

GLYMESE
MELITASE
DIABINESE
GLUCAMIDE
DIABEMIDE
CHLORPROPAMIDE
4-CHLORO-N-((PROPYLAMINO)CARBONYL)BENZENESULFONAMIDE
N-PROPYL-N'-P-CHLOROPHENYLSULFONYLCARBAMIDE
4-CHLORO-N-[(PROPYLAMINO)CARBONYL]BENZENESULFONAMIDE
1-(P-CHLOROBENZENESULFONYL)-3-PROPYLUREA
N-PROPYL-N'-(P-CHLOROBENZENESULFONYL)UREA
CHLORPROPAMID
1-PROPYL-3-(P-CHLOROBENZENESULFONYL)UREA
1-(P-CHLOROPHENYLSULFONYL)-3-PROPYLUREA
N-(P-CHLOROBENZENESULFONYL)-N'-PROPYLUREA
CLORPROPAMIDA
GLUCAMIDE®
N-(4-CHLOROPHENYLSULFONYL)-N'-PROPYLUREA
DIABENESE®
CHLORPROPAMIDUM
drugbank:00672
pubchem.compound:2727
chemidplus:94-20-2
rxcui:2404
chembl:CHEMBL498

Drug Info:

Year of Approval	1958
Drug Class	hypoglycemic agents
FDA Approval	1958
Drug Class	small molecule
Drug Indications	Hypoglycemic Agents

(4 More Sources)

Publications:

Mizuno et al., 2008, Type 2 diabetes and oral antihyperglycemic drugs., Curr. Med. Chem.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

CHLORPROPAMIDE KCNJ1

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND
CHLORPROPAMIDE KCNJ10

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHLORPROPAMIDE ABCC8

Interaction Score: 0.66

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
18220763

Sources:
ChemblInteractions
CHLORPROPAMIDE KCNJ11

Interaction Score: 0.2

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CHLORPROPAMIDE G6PD

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
CHLORPROPAMIDE NFKB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORPROPAMIDE CYP2C9

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLORPROPAMIDE CYP2C19

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLORPROPAMIDE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLORPROPAMIDE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
CHLORPROPAMIDE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: CHLORPROPAMIDE
- Version: 01-August-2011
Alternate Names:

CHLORPROPAMIDE Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1958

Publications:
TdgClinicalTrial: CHLORPROPAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1958

Publications:
DTC: CHLORPROPAMIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL498 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
TTD: Chlorpropamide
- Version: 2020.06.01
Alternate Names:

D00BCP TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL498
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: chlorpropamide
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL498
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Chlorpropamide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Sulfonylurea receptor 1, Kir6.2 blocker
Direct Interaction	yes

Novel drug target	Established target
Trial Name	-

blocker (inhibitory)
inhibitor (inhibitory)

CHLORPROPAMIDE Drug Record

CHLORPROPAMIDE chembl:CHEMBL498 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: None found

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: 18220763

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

TEND: CHLORPROPAMIDE

Alternate Names: CHLORPROPAMIDE Primary Drug Name

Drug Info: Drug Class hypoglycemic agents Year of Approval 1958

Publications:

TdgClinicalTrial: CHLORPROPAMIDE

Alternate Names:

Drug Info: Drug Indications Hypoglycemic Agents Drug Class small molecule FDA Approval 1958

Publications:

DTC: CHLORPROPAMIDE

Alternate Names: CHEMBL498 ChEMBL Drug ID

Drug Info:

Publications: Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for &gt;200 compounds., Chem Res Toxicol

TTD: Chlorpropamide

Alternate Names: D00BCP TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL498

Alternate Names:

Drug Info:

Publications:

PharmGKB: chlorpropamide

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL498

Alternate Names:

Drug Info:

Publications:

FDA: Chlorpropamide

Alternate Names:

Drug Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
18220763

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Alternate Names:

CHLORPROPAMIDE Primary Drug Name

Drug Info:

Drug Class hypoglycemic agents

Year of Approval 1958

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1958

Alternate Names:

CHEMBL498 ChEMBL Drug ID

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Alternate Names:

D00BCP TTD Drug ID