DGIdb - DIGITOXIN Drug Record

DIGITOXIN chembl:CHEMBL254219 Approved

Alternate Names:

NSC-7529
DIGIMERCK
CRYSTODIGIN
DIGITOXOSIDE
NATIVELLE DIGITALINE
DIGITOXIN
CRYSTODIGIN (TN)
UNIDIGIN
DIGITOKSIN
DIGITOXINUM
chemidplus:71-63-6
pubchem.compound:441207
chembl:CHEMBL254219
rxcui:3403
drugbank:01396

Drug Info:

Drug Class	anti-arrhythmia agents
Year of Approval	approved before 1982
Drug Class	cardiotonic agents
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Cardiotonic Agents
Drug Indications	Anti-Arrhythmia Agents

(2 More Sources)

Publications:

López-Lázaro et al., 2005, Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients., J. Nat. Prod.
Marcus et al., 1975, The reactivity of derivatives of digoxin and digitoxin as measured by the Na-K-atpase displacement assay and by radioimmunoassay., J. Lab. Clin. Med.
Prignitz et al., 1976, [Influence of roentgen rays on electrolyte changes and metabolism of the myocardium. VII. Radiation-induced inhibition of the sodium- and potassium--activated microscomal-trasport ATPase]., Strahlentherapie
Bluschke et al., 1976, Increase in the (Na+ + K+)-ATPase activity in heart muscle after chronic treatment with digitoxin or potassium deficient diet., Eur. J. Pharmacol.
Fricke, 1976, [New aspects on the mode of action of cardiac glycosides]., Fortschr. Med.
Hauck et al., 2009, Isoform specificity of cardiac glycosides binding to human Na+,K+-ATPase alpha1beta1, alpha2beta1 and alpha3beta1., Eur. J. Pharmacol.
Chen et al., 2001, Direct inhibitory effect of digitalis on progesterone release from rat granulosa cells., Br. J. Pharmacol.

DIGITOXIN ATP1A1

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Trial Name -

PMIDs:
123547 131389 132355 136410 19751721 11309248

Sources:
TdgClinicalTrial ChemblInteractions TEND
DIGITOXIN ATP1B1

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN ATP1A3

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN ATP1B3

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN ATP1A4

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN ATP1B2

Interaction Score: 0.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN ATP1A2

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN FXYD2

Interaction Score: 0.69

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIGITOXIN TOP2B

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16309315

Sources:
DTC
DIGITOXIN STAT3

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN TOP2A

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16309315

Sources:
DTC
DIGITOXIN NR3C1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN SMAD3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIGITOXIN AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DIGITOXIN
- Version: 01-August-2011
Alternate Names:

DIGITOXIN Primary Drug Name

Drug Info:

Drug Class cardiotonic agents

Year of Approval approved before 1982

Drug Class anti-arrhythmia agents

Publications:
TdgClinicalTrial: DIGITOXIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Cardiotonic Agents

Drug Class small molecule

Publications:
DTC: DIGITOXIN
- Version: 02-September-2020
Alternate Names:

CHEMBL254219 ChEMBL Drug ID

Drug Info:

Publications:

López-Lázaro et al., 2005, Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients., J. Nat. Prod.
TTD: Digitoxin
- Version: 2020.06.01
Alternate Names:

D0M3QP TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL254219
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL254219
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Sodium/potassium-transporting ATPase inhibitor
Trial Name	-

DIGITOXIN Drug Record

DIGITOXIN chembl:CHEMBL254219 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Trial Name -

PMIDs: 123547 131389 132355 136410 19751721 11309248

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16309315

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16309315

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DIGITOXIN

Alternate Names: DIGITOXIN Primary Drug Name

Drug Info: Drug Class cardiotonic agents Year of Approval approved before 1982 Drug Class anti-arrhythmia agents

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Trial Name -

PMIDs:
123547 131389 132355 136410 19751721 11309248

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium/potassium-transporting ATPase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16309315

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16309315

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIGITOXIN Primary Drug Name

Drug Info:

Drug Class cardiotonic agents

Year of Approval approved before 1982

Drug Class anti-arrhythmia agents

Drug Info:

Drug Indications Anti-Arrhythmia Agents

Drug Indications Cardiotonic Agents

Drug Class small molecule

Alternate Names:

CHEMBL254219 ChEMBL Drug ID

Publications:

López-Lázaro et al., 2005, Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients., J. Nat. Prod.

Alternate Names:

D0M3QP TTD Drug ID