DGIdb - DROSPIRENONE Drug Record

DROSPIRENONE chembl:CHEMBL1509 Approved

Alternate Names:

ANGELIQ
ZK-30595
DROSPIRENONE
SLYND
YASMIN®
6BETA,7BETA;15BETA,16BETA-DIMETHYLENE-3-OXO-17ALPHA-PREGN-4-ENE-21,17-CARBOLACTONE
6Β,7Β,15Β,16Β-DIMETHYLENE-3-OXO-17Α-PREGN-4-ENE-21,17 CARBOLACTONE
DIHYDROSPIRORENONE
DEHYDROSPIRORENONE
DRSP
DROSPIRENONA
ZK30595
1,2-DIHYDROSPIRORENONE
DROSPIRENONUM
chemidplus:67392-87-4
drugbank:01395
pubchem.compound:68873
chembl:CHEMBL1509
rxcui:11636

Drug Info:

Drug Indications	contraceptive
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hormone replacement
Drug Class	contraceptives
Year of Approval	2001

(3 More Sources)

Publications:

Krattenmacher, 2000, Drospirenone: pharmacology and pharmacokinetics of a unique progestogen., Contraception
Muhn et al., 1995, Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity., Ann. N. Y. Acad. Sci.
Oelkers W, 2004, Drospirenone, a progestogen with antimineralocorticoid properties: a short review., Mol Cell Endocrinol
Sitruk-Ware, 2004, New progestogens: a review of their effects in perimenopausal and postmenopausal women., Drugs Aging
Bray et al., 2005, Quantitative analysis of gene regulation by seven clinically relevant progestins suggests a highly similar mechanism of action through progesterone receptors in T47D breast cancer cells., J. Steroid Biochem. Mol. Biol.
Arias-Loza et al., 2006, Medroxyprogesterone acetate but not drospirenone ablates the protective function of 17 beta-estradiol in aldosterone salt-treated rats., Hypertension
Sitruk-Ware, New progestagens for contraceptive use., Hum. Reprod. Update
Fuhrmann et al., 1996, The novel progestin drospirenone and its natural counterpart progesterone: biochemical profile and antiandrogenic potential., Contraception
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Oelkers, 1996, Effects of estrogens and progestogens on the renin-aldosterone system and blood pressure., Steroids
Oelkers W, 2002, Antimineralocorticoid activity of a novel oral contraceptive containing drospirenone, a unique progestogen resembling natural progesterone., Eur J Contracept Reprod Health Care

DROSPIRENONE NR3C2

Interaction Score: 8.59

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ethinyl estradiol + drospirenone,Yaz

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources:
TdgClinicalTrial ChemblInteractions TTD
DROSPIRENONE PGR

Interaction Score: 3.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources:
TdgClinicalTrial ChemblInteractions TEND
DROSPIRENONE AR

Interaction Score: 0.09

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ethinyl estradiol + drospirenone ,Yaz

Novel drug target Established target

PMIDs:
11024226 7625729 15134826

Sources:
DTC TdgClinicalTrial
DROSPIRENONE CYP2C19

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Drospirenone,Ethinyl Estradiol

PMIDs:
None found

Sources:
FDA

TEND: DROSPIRENONE
- Version: 01-August-2011
Alternate Names:

DROSPIRENONE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class contraceptives

Publications:
TdgClinicalTrial: DROSPIRENONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Publications:
DTC: DROSPIRENONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1509 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Drospirenone
- Version: 2020.06.01
Alternate Names:

D0Z4ZT TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1509
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1509
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Drospirenone
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	ethinyl estradiol + drospirenone,Yaz
Mechanism of Interaction	Mineralocorticoid receptor antagonist

Direct Interaction	yes
Mechanism of Interaction	Progesterone receptor agonist
Trial Name	drospirenone plus estradiol,Angeliq

Trial Name	ethinyl estradiol + drospirenone ,Yaz
Novel drug target	Established target

DROSPIRENONE Drug Record

DROSPIRENONE chembl:CHEMBL1509 Approved

Alternate Names:

Drug Info:

Publications:

DROSPIRENONE NR3C2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ethinyl estradiol + drospirenone,Yaz Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs: 11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources: TdgClinicalTrial ChemblInteractions TTD

DROSPIRENONE PGR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Progesterone receptor agonist Trial Name drospirenone plus estradiol,Angeliq

PMIDs: 15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources: TdgClinicalTrial ChemblInteractions TEND

DROSPIRENONE AR

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ethinyl estradiol + drospirenone ,Yaz Novel drug target Established target

PMIDs: 11024226 7625729 15134826

Sources: DTC TdgClinicalTrial

DROSPIRENONE CYP2C19

Interaction Types & Directionality: n/a

Interaction Info: Combination therapy Drospirenone,Ethinyl Estradiol

PMIDs: None found

Sources: FDA

TEND: DROSPIRENONE

Alternate Names: DROSPIRENONE Primary Drug Name

Drug Info: Year of Approval 2001 Drug Class contraceptives

Publications:

TdgClinicalTrial: DROSPIRENONE

Alternate Names:

Drug Info: Drug Indications hormone replacement Drug Class Small Molecule FDA Approval approved

Publications:

DTC: DROSPIRENONE

Alternate Names: CHEMBL1509 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Drospirenone

Alternate Names: D0Z4ZT TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1509

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1509

Alternate Names:

Drug Info:

Publications:

FDA: Drospirenone

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ethinyl estradiol + drospirenone,Yaz

Mechanism of Interaction Mineralocorticoid receptor antagonist

PMIDs:
11024226 11752352 8732994 7625729 8922878 12659403 15134826

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Progesterone receptor agonist

Trial Name drospirenone plus estradiol,Angeliq

PMIDs:
15493951 16157482 17000933 11024226 16291771 8922878 7625729

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ethinyl estradiol + drospirenone ,Yaz

Novel drug target Established target

PMIDs:
11024226 7625729 15134826

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Combination therapy Drospirenone,Ethinyl Estradiol

PMIDs:
None found

Sources:
FDA

Alternate Names:

DROSPIRENONE Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class contraceptives

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

CHEMBL1509 ChEMBL Drug ID

Alternate Names:

D0Z4ZT TTD Drug ID