DGIdb - ENPROFYLLINE Drug Record

ENPROFYLLINE chembl:CHEMBL279898

Alternate Names:

ENPROFYLLINE
D-4028
3,7-DIHYDRO-3-PROPYL-1H-PURINE-2,6-DIONE
ENPROFILINA
3-PROPYLXANTHINE
ENPROFYLLINUM
3-PROPYL-3,7-DIHYDRO-PURINE-2,6-DIONE
3-N-PROPYLXANTHINE
drugbank:00824
chembl:CHEMBL279898
chemidplus:41078-02-8
pubchem.compound:1676

Drug Info:

Drug Class	antiarrhythmic agents
Drug Class	bronchodilator agents
Drug Class	anti-asthmatic agents
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Bronchodilator Agents
Drug Indications	Antiarrhythmic Agents
Drug Indications	Anti-Asthmatic Agents

(0 More Sources)

Publications:

Ukena et al., 1985, Effects of enprofylline on A1 and A2 adenosine receptors., Eur. J. Pharmacol.
Featherstone et al., 2004, Long-term hypothermic lung preservation: does adenosine A1 receptor antagonism have a role in ischemic preconditioning protection?, Interact Cardiovasc Thorac Surg
Berg et al., 1987, Effects of different phosphodiesterase-inhibiting drugs on human pregnant myometrium: an in vitro study., Arch Int Pharmacodyn Ther
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Dulloo et al., 1991, Peripheral mechanisms of thermogenesis induced by ephedrine and caffeine in brown adipose tissue., Int J Obes
Dar, 1990, Central adenosinergic system involvement in ethanol-induced motor incoordination in mice., J. Pharmacol. Exp. Ther.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Monteiro JP et al., 2016, Structure-Bioactivity Relationships of Methylxanthines: Trying to Make Sense of All the Promises and the Drawbacks., Molecules
Ukena D et al., 1993, Adenosine receptor-blocking xanthines as inhibitors of phosphodiesterase isozymes., Biochem Pharmacol

ENPROFYLLINE PDE4A

Interaction Score: 9.27

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3002801 17670210 3446047 11752352 1885257 2262902

Sources:
TdgClinicalTrial TEND TTD
ENPROFYLLINE PDE4B

Interaction Score: 5.8

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 27472311 7680859

Sources:
TdgClinicalTrial TEND

TEND: ENPROFYLLINE
- Version: 01-August-2011
Alternate Names:

ENPROFYLLINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class anti-asthmatic agents

Drug Class bronchodilator agents

Publications:
TdgClinicalTrial: ENPROFYLLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anti-Asthmatic Agents

Drug Indications Antiarrhythmic Agents

Drug Indications Bronchodilator Agents

Publications:
TTD: Enprofylline
- Version: 2020.06.01
Alternate Names:

D09AMZ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL279898
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

ENPROFYLLINE Drug Record

ENPROFYLLINE chembl:CHEMBL279898

Alternate Names:

Drug Info:

Publications:

ENPROFYLLINE PDE4A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 3002801 17670210 3446047 11752352 1885257 2262902

Sources: TdgClinicalTrial TEND TTD

ENPROFYLLINE PDE4B

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 27472311 7680859

Sources: TdgClinicalTrial TEND

TEND: ENPROFYLLINE

Alternate Names: ENPROFYLLINE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class anti-asthmatic agents Drug Class bronchodilator agents

Publications:

TdgClinicalTrial: ENPROFYLLINE

Alternate Names:

Drug Info: Drug Indications Anti-Asthmatic Agents Drug Indications Antiarrhythmic Agents Drug Indications Bronchodilator Agents

Publications:

TTD: Enprofylline

Alternate Names: D09AMZ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL279898

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
3002801 17670210 3446047 11752352 1885257 2262902

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 27472311 7680859

Sources:
TdgClinicalTrial TEND

Alternate Names:

ENPROFYLLINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class anti-asthmatic agents

Drug Class bronchodilator agents

Drug Info:

Drug Indications Anti-Asthmatic Agents

Drug Indications Antiarrhythmic Agents

Drug Indications Bronchodilator Agents

Alternate Names:

D09AMZ TTD Drug ID