5142 |
PHOSPHODIESTERASE 4B |
PDE4B |
DPDE4 |
PDEIVB |
600127 |
8781 |
ENSG00000184588 |
OTTHUMG00000009088 |
PDE4B_HUMAN |
Q07343 |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343] |
PDE32 |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
PA33129 |
T10265 |
Target Class | Enzymes |
Target Subclass | EC:3.1.4.17 |
Human Readable Name | DRUGGABLE GENOME |
Target Main Class | Enzymes |
Target Subclass | 3.1.4.17 |
Interpro Acc | IPR002073 |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | PDEase_catalytic_dom |
Interpro Name | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
Uniprot Status | Swiss-Prot |
Gene Biotype | PROTEIN_CODING |
DRUGGABLE GENOME |
n/a |
Trial Name | Oglemilast, GRC 3886 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Trial Name | roflumilast,Daxas |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
Novel drug target | Established target |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | apremilast, CC-10004 |
Novel drug target | Established target |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
inhibitor (inhibitory) |
Trial Name | ibudilast, MN-166, AV411 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | ADC4022, low-dose inhaled theophylline |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
inhibitor (inhibitory) |
Trial Name | pentoxifylline, EHT0201 |
Novel drug target | Established target |
Mechanism of Interaction | 3',5'-cyclic phosphodiesterase inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Phosphodiesterase 4 inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | EHT 0202 |
Novel drug target | Established target |
n/a |
Trial Name | SRT501 |
Novel drug target | Established target |
Trial Name | Resveratrol |
inhibitor (inhibitory) |
Mechanism of Interaction | 3',5'-cyclic phosphodiesterase inhibitor |
Direct Interaction | yes |
PDE4B | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
PDE4B_HUMAN | Uniprot Id |
5142 | Entrez Gene Id |
Q07343 | Uniprot Accession |
Target Main Class | Enzymes |
Target Subclass | 3.1.4.17 |
PDE4B | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:3.1.4.17 |
CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B (EC 3.1.4.17) (DPDE4) (PDE32). [SOURCE:UNIPROT/SWISSPROT;ACC:Q07343] | Description |
ENSG00000184588 | Ensembl Gene Id |
PDE4B | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PDE4B_HUMAN | Uniprot Id |
5142 | Entrez Gene Id |
PDE4B | Uniprot Gene Name |
Interpro Acc | IPR002073 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
DRUGGABLE GENOME |
PA33129 | PharmGKB ID |
PDE4B | TTD Gene Abbreviation |
T10265 | TTD Target ID |
DPDE4 | GENE_SYMBOL |
PDE4B | GENE_SYMBOL |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | UNIPROT |
ENSG00000184588 | Gene Symbol |
PDE4B | Ensembl Id |
DRUGGABLE GENOME |