DGIdb - FENRETINIDE Drug Record

FENRETINIDE chembl:CHEMBL7301 Antineoplastic

Alternate Names:

4-HPR
FENRETINIDE
MCN-R-1967
ALL-TRANS-4'-HYDROXYRETINANILIDE
4-HYDROXY(PHENYL)RETINAMIDE
N-(4-HYDROXYPHENYL)RETINAMIDE
N-(4-HYDROXYPHENYL)ALL-TRANS RETINAMIDE
rxcui:24870
chemidplus:65646-68-6
chembl:CHEMBL7301
drugbank:05076
pubchem.compound:5288209

Drug Info:

FDA Approval	approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent

(3 More Sources)

Publications:

Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.
Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.
Hsieh et al., 2000, Apoptosis and restriction of G(1)/S cell cycle by fenretinide in Burkitt's lymphoma mutu I cell line accessed with bcl-6 down-regulation., Biochem. Biophys. Res. Commun.
Yang et al., 2005, Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes., Nature
Campos-Sandoval JA et al., 2011, Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor., J Med Chem
Pergolizzi et al., 1999, Role of retinoic acid receptor overexpression in sensitivity to fenretinide and tumorigenicity of human ovarian carcinoma cells., Int. J. Cancer
Chen et al., 2006, Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, pax-6, tubulin beta-III, NSE, and bag-1 proteins., Mol. Vis.
Roberson et al., 1997, Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells., Cell Growth Differ.
Kerl et al., 2013, The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells., BMC Cancer
Vilela et al., 2006, Inhibition of IL-8 release from CFTR-deficient lung epithelial cells following pre-treatment with fenretinide., Int. Immunopharmacol.

FENRETINIDE RBP4

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16034410 21591606

Sources:
DTC NCI
FENRETINIDE BCL6

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11027625

Sources:
NCI
FENRETINIDE SMARCB1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fenretinide + Vorinostat

Indication/Tumor Type rhabdoid cancer

Response Type sensitive

PMIDs:
23764045

Sources:
JAX-CKB
FENRETINIDE ENO2

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17110918

Sources:
NCI
FENRETINIDE DDIT3

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17273769 12234979

Sources:
NCI
FENRETINIDE RARA

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
10328240

Sources:
TdgClinicalTrial NCI
FENRETINIDE RARB

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
FENRETINIDE RARG

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fenretinide, RT-101

PMIDs:
None found

Sources:
TdgClinicalTrial
FENRETINIDE TGFB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8993839

Sources:
NCI
FENRETINIDE CXCL8

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16979119

Sources:
NCI
FENRETINIDE THPO

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE RORC

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE NFKB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE MTOR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE ESR1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE KDM4E

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE ALDH1A1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FENRETINIDE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: FENRETINIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval approved

Publications:

NCI: FENRETINIDE

Version: 14-September-2017

Alternate Names:

C1098 NCI drug code

Drug Info:

Publications:

Lovat et al., 2002, GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma., Cancer Res.

Kouhara et al., 2007, Fenretinide up-regulates DR5/TRAIL-R2 expression via the induction of the transcription factor CHOP and combined treatment with fenretinide and TRAIL induces synergistic apoptosis in colon cancer cell lines., Int. J. Oncol.

Hsieh et al., 2000, Apoptosis and restriction of G(1)/S cell cycle by fenretinide in Burkitt's lymphoma mutu I cell line accessed with bcl-6 down-regulation., Biochem. Biophys. Res. Commun.

NCI: 4-HPR
- Version: 14-September-2017
Alternate Names:

C1098 NCI drug code

Drug Info:

Publications:

Roberson et al., 1997, Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells., Cell Growth Differ.
DTC: FENRETINIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL7301 ChEMBL Drug ID

Drug Info:

Publications:

Campos-Sandoval JA et al., 2011, Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor., J Med Chem
JAX-CKB: Fenretinide
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Kerl et al., 2013, The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells., BMC Cancer
TTD: Fenretinide
- Version: 2020.06.01
Alternate Names:

D08JAC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL7301
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

combination therapy	Fenretinide + Vorinostat
Indication/Tumor Type	rhabdoid cancer
Response Type	sensitive

Trial Name	fenretinide, RT-101
Novel drug target	Established target

FENRETINIDE Drug Record

FENRETINIDE chembl:CHEMBL7301 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16034410 21591606

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11027625

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Fenretinide + Vorinostat Indication/Tumor Type rhabdoid cancer Response Type sensitive

PMIDs: 23764045

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17110918

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17273769 12234979

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name fenretinide, RT-101 Novel drug target Established target

PMIDs: 10328240

Sources: TdgClinicalTrial NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name fenretinide, RT-101 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name fenretinide, RT-101

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8993839

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16979119

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
16034410 21591606

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
11027625

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Fenretinide + Vorinostat

Indication/Tumor Type rhabdoid cancer

Response Type sensitive

PMIDs:
23764045

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
17110918

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17273769 12234979

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
10328240

Sources:
TdgClinicalTrial NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name fenretinide, RT-101

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name fenretinide, RT-101

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
8993839

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16979119

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a