DGIdb - FLUNARIZINE Drug Record

FLUNARIZINE chembl:CHEMBL30008 Approved

Alternate Names:

FLUNARIZINE
FLUNARIZINUM
1-[BIS(4-FLUOROPHENYL)METHYL]-4-[(2E)-3-PHENYLPROP-2-EN-1-YL]PIPERAZINE
FLUNARIZINA
pubchem.compound:941361
chemidplus:52468-60-7
drugbank:04841
chembl:CHEMBL30008
rxcui:4459

Drug Info:

Drug Class	vasodilator agents
Drug Class	anticonvulsants
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Anticonvulsants

(1 More Sources)

Publications:

Taylor et al., 1986, Interactions of verapamil, D 600, flunarizine and nifedipine with cerebral histamine-receptors., Neurochem. Int.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Castellino SM et al., 1995, Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma., Br J Cancer
Kavanagh BD et al., 1993, The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment., Br J Cancer
Gajdus M et al., 2011, Role of calcium and calmodulin in reaction of gastric fundus contraction., Postepy Hig Med Dosw (Online)
Santi et al., 2002, Differential inhibition of T-type calcium channels by neuroleptics., J. Neurosci.
Uebele et al., 2009, Positive allosteric interaction of structurally diverse T-type calcium channel antagonists., Cell Biochem. Biophys.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

FLUNARIZINE CALM1

Interaction Score: 13.74

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17016423 17139284 7779708 8471430 21918260

Sources:
TEND
FLUNARIZINE CACNA1I

Interaction Score: 2.58

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
TdgClinicalTrial TEND
FLUNARIZINE CACNA1G

Interaction Score: 2.42

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
TdgClinicalTrial TEND
FLUNARIZINE CACNA1H

Interaction Score: 2.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD
FLUNARIZINE CACNA1A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FLUNARIZINE HRH1

Interaction Score: 0.27

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20493137 17016423 17139284

Sources:
TdgClinicalTrial TEND
FLUNARIZINE ATAD5

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUNARIZINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUNARIZINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FLUNARIZINE
- Version: 01-August-2011
Alternate Names:

FLUNARIZINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class anticonvulsants

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: FLUNARIZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
TTD: Flunarizine
- Version: 2020.06.01
Alternate Names:

D05CEU TTD Drug ID

Drug Info:

Publications:
DTC: FLUNARIZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL30008 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL30008
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

FLUNARIZINE Drug Record

FLUNARIZINE chembl:CHEMBL30008 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17016423 17139284 7779708 8471430 21918260

Sources: TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11784784 19582593 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11784784 19582593 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11784784 19582593 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 20493137 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FLUNARIZINE

Alternate Names: FLUNARIZINE Primary Drug Name

Drug Info: Year of Approval not approved by the fda Drug Class anticonvulsants Drug Class vasodilator agents

Publications:

TdgClinicalTrial: FLUNARIZINE

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

TTD: Flunarizine

Alternate Names: D05CEU TTD Drug ID

Drug Info:

Publications:

DTC: FLUNARIZINE

Alternate Names: CHEMBL30008 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL30008

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17016423 17139284 7779708 8471430 21918260

Sources:
TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11784784 19582593 17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
20493137 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FLUNARIZINE Primary Drug Name

Drug Info:

Year of Approval not approved by the fda

Drug Class anticonvulsants

Drug Class vasodilator agents

Drug Info:

Drug Indications Anticonvulsants

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

D05CEU TTD Drug ID

Alternate Names:

CHEMBL30008 ChEMBL Drug ID