DGIdb - MARAVIROC Drug Record

MARAVIROC chembl:CHEMBL1201187 Approved

Alternate Names:

SELZENTRY
REL-MARAVIROC
UK-427857
MARAVIROC
CELSENTRI

Drug Info:

Drug Indications	antiviral agent,HIV
Drug Class	Small Molecule
FDA Approval	approved
Year of Approval	2007
Drug Class	anti-viral
Drug Class	anti-hiv agents

(3 More Sources)

Publications:

Agrawal-Gamse et al., 2009, Adaptive mutations in a human immunodeficiency virus type 1 envelope protein with a truncated V3 loop restore function by improving interactions with CD4., J. Virol.
Levy, 2009, HIV pathogenesis: 25 years of progress and persistent challenges., AIDS
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Napier et al., 2005, Molecular cloning and radioligand binding characterization of the chemokine receptor CCR5 from rhesus macaque and human., Biochem. Pharmacol.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

MARAVIROC CCR5

Interaction Score: 33.73

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name Selzentry

PMIDs:
19692476 19098484 11752352 16298345 17016423 17139284

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
MARAVIROC OPRM1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: MARAVIROC
- Version: 01-August-2011
Alternate Names:

MARAVIROC Primary Drug Name

Drug Info:

Drug Class anti-hiv agents

Drug Class anti-viral

Year of Approval 2007

Publications:
TdgClinicalTrial: MARAVIROC
- Version: January-2014
Alternate Names:

Drug Info:

FDA Approval approved

Drug Class Small Molecule

Drug Indications antiviral agent,HIV

Publications:
DTC: MARAVIROC
- Version: 02-September-2020
Alternate Names:

CHEMBL1201187 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Maraviroc
- Version: 2020.06.01
Alternate Names:

D0NR6S TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1201187
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201187
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: maraviroc
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	C-C chemokine receptor type 5 antagonist
Direct Interaction	yes
Trial Name	Selzentry

MARAVIROC Drug Record

MARAVIROC chembl:CHEMBL1201187 Approved

Alternate Names:

Drug Info:

Publications:

MARAVIROC CCR5

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction C-C chemokine receptor type 5 antagonist Direct Interaction yes Trial Name Selzentry

PMIDs: 19692476 19098484 11752352 16298345 17016423 17139284

Sources: DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

MARAVIROC OPRM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: MARAVIROC

Alternate Names: MARAVIROC Primary Drug Name

Drug Info: Drug Class anti-hiv agents Drug Class anti-viral Year of Approval 2007

Publications:

TdgClinicalTrial: MARAVIROC

Alternate Names:

Drug Info: FDA Approval approved Drug Class Small Molecule Drug Indications antiviral agent,HIV

Publications:

DTC: MARAVIROC

Alternate Names: CHEMBL1201187 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Maraviroc

Alternate Names: D0NR6S TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1201187

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201187

Alternate Names:

Drug Info:

Publications:

PharmGKB: maraviroc

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction C-C chemokine receptor type 5 antagonist

Direct Interaction yes

Trial Name Selzentry

PMIDs:
19692476 19098484 11752352 16298345 17016423 17139284

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

MARAVIROC Primary Drug Name

Drug Info:

Drug Class anti-hiv agents

Drug Class anti-viral

Year of Approval 2007

Drug Info:

FDA Approval approved

Drug Class Small Molecule

Drug Indications antiviral agent,HIV

Alternate Names:

CHEMBL1201187 ChEMBL Drug ID

Alternate Names:

D0NR6S TTD Drug ID