DGIdb - METHYSERGIDE Drug Record

METHYSERGIDE chembl:CHEMBL485253 Approved

Alternate Names:

METHYSERGIDE
DESERIL

Drug Info:

Drug Class	vasoconstrictor agents
Year of Approval	1962
Drug Class	anti-migraine agents
FDA Approval	1962
Drug Indications	Vasoconstrictor Agents
Drug Indications	Anti-migraine agents
Drug Class	small molecule

(1 More Sources)

Publications:

Pranzatelli et al., 1991, Characterization of 5-hydroxytryptamine 1A-like binding sites in human ganglioneuroblastoma., Neurosci. Lett.
Sugimoto et al., 2003, The tricyclic antidepressant clomipramine increases plasma glucose levels of mice., J. Pharmacol. Sci.
Scrogin et al., 2000, Methysergide delays the decompensatory responses to severe hemorrhage by activating 5-HT(1A) receptors., Am. J. Physiol. Regul. Integr. Comp. Physiol.
Skyba et al., 2003, Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord., Pain
Sugimoto et al., 2003, Involvement of 5-HT(2) receptor in imipramine-induced hyperglycemia in mice., Horm. Metab. Res.
Johnson et al., 2003, An investigation of the 5-HT2C receptor gene as a migraine candidate gene., Am. J. Med. Genet. B Neuropsychiatr. Genet.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Castilho et al., 1999, Antinociception elicited by aversive stimulation of the inferior colliculus., Pharmacol. Biochem. Behav.
Shaw et al., 2000, Role of the 5-HT(2A)receptor and alpha(1)-adrenoceptor in the contractile response of rat pulmonary artery to 5-HT in the presence and absence of nitric oxide., Pulm Pharmacol Ther
Connor et al., 2001, Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore., Life Sci.
Geerts et al., 1999, Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery., Br. J. Pharmacol.
Prins et al., 2001, Characterization of the receptors involved in the 5-HT-induced excitation of canine antral longitudinal muscle., Br. J. Pharmacol.

METHYSERGIDE HTR7

Interaction Score: 0.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14501155

Sources:
TdgClinicalTrial TEND
METHYSERGIDE HTR1A

Interaction Score: 0.77

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1838579 14501155 11049861 14581123 14517765

Sources:
TdgClinicalTrial TEND
METHYSERGIDE HTR2C

Interaction Score: 0.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12555241 11752352

Sources:
TdgClinicalTrial TEND TTD
METHYSERGIDE HTR2A

Interaction Score: 0.43

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10080233 11061982 11720080 10455282 11704657

Sources:
TdgClinicalTrial TEND
METHYSERGIDE RGS4

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE DRD1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE RECQL

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE ALDH1A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHYSERGIDE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: METHYSERGIDE
- Version: 01-August-2011
Alternate Names:

METHYSERGIDE Primary Drug Name

Drug Info:

Drug Class anti-migraine agents

Year of Approval 1962

Drug Class vasoconstrictor agents

Publications:
TdgClinicalTrial: METHYSERGIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

Drug Indications Anti-migraine agents

Drug Indications Vasoconstrictor Agents

Publications:
DTC: METHYSERGIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1065 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Methysergide
- Version: 2020.06.01
Alternate Names:

D0O6GC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL485253
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

METHYSERGIDE Drug Record

METHYSERGIDE chembl:CHEMBL485253 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 14501155

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 1838579 14501155 11049861 14581123 14517765

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12555241 11752352

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 10080233 11061982 11720080 10455282 11704657

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: METHYSERGIDE

Alternate Names: METHYSERGIDE Primary Drug Name

Drug Info: Drug Class anti-migraine agents Year of Approval 1962 Drug Class vasoconstrictor agents

Publications:

TdgClinicalTrial: METHYSERGIDE

Alternate Names:

Drug Info: Drug Class small molecule Drug Indications Anti-migraine agents Drug Indications Vasoconstrictor Agents

Publications:

DTC: METHYSERGIDE

Alternate Names: CHEMBL1065 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Methysergide

Alternate Names: D0O6GC TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL485253

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
14501155

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
1838579 14501155 11049861 14581123 14517765

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12555241 11752352

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
10080233 11061982 11720080 10455282 11704657

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

METHYSERGIDE Primary Drug Name

Drug Info:

Drug Class anti-migraine agents

Year of Approval 1962

Drug Class vasoconstrictor agents

Drug Info:

Drug Class small molecule

Drug Indications Anti-migraine agents

Drug Indications Vasoconstrictor Agents

Alternate Names:

CHEMBL1065 ChEMBL Drug ID

Alternate Names:

D0O6GC TTD Drug ID