DGIdb - ROMIPLOSTIM Drug Record

ROMIPLOSTIM chembl:CHEMBL1201832 ApprovedAntineoplastic

Alternate Names:

ROMIPLOSTIM
NPLATE
AMG 531
SID49674962
SEMAXINIB
SID50107014
SEMAXANIB
SU-5416
rxcui:805452
chembl:CHEMBL1201832
chemidplus:267639-76-9
drugbank:05332

Drug Info:

Year of Approval	2008
Drug Class	hematopoiesis stimulating agent
FDA Approval	approved
Drug Class	fusion protein
Drug Indications	for treatment of thrombocytopenia

(1 More Sources)

Publications:

Krzyzanski et al., 2013, Pharmacokinetic and pharmacodynamic modeling of romiplostim in animals., Pharm. Res.
Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One

ROMIPLOSTIM MPL

Interaction Score: 3.51

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

Trial Name romiplostim, AMG 531,Nplate

PMIDs:
23250851

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ROMIPLOSTIM AHR

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22970246

Sources:
TTD
ROMIPLOSTIM KIT

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROMIPLOSTIM RET

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROMIPLOSTIM PDGFRA

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROMIPLOSTIM PDGFRB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROMIPLOSTIM FGFR1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROMIPLOSTIM KDR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: ROMIPLOSTIM
- Version: 01-August-2011
Alternate Names:

ROMIPLOSTIM Primary Drug Name

Drug Info:

Drug Class hematopoiesis stimulating agent

Year of Approval 2008

Publications:
TdgClinicalTrial: ROMIPLOSTIM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of thrombocytopenia

Drug Class fusion protein

FDA Approval approved

Publications:
TTD: Romiplostim
- Version: 2020.06.01
Alternate Names:

D01PZD TTD Drug ID

Drug Info:

Publications:

Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One
ChemblDrugs: chembl:CHEMBL1201832
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1201832
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Thrombopoietin receptor agonist
Direct Interaction	yes
Trial Name	romiplostim, AMG 531,Nplate

ROMIPLOSTIM Drug Record

ROMIPLOSTIM chembl:CHEMBL1201832 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Thrombopoietin receptor agonist Direct Interaction yes Trial Name romiplostim, AMG 531,Nplate

PMIDs: 23250851

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22970246

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: ROMIPLOSTIM

Alternate Names: ROMIPLOSTIM Primary Drug Name

Drug Info: Drug Class hematopoiesis stimulating agent Year of Approval 2008

Publications:

TdgClinicalTrial: ROMIPLOSTIM

Alternate Names:

Drug Info: Drug Indications for treatment of thrombocytopenia Drug Class fusion protein FDA Approval approved

Publications:

TTD: Romiplostim

Alternate Names: D01PZD TTD Drug ID

Drug Info:

Publications: Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One

ChemblDrugs: chembl:CHEMBL1201832

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1201832

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Thrombopoietin receptor agonist

Direct Interaction yes

Trial Name romiplostim, AMG 531,Nplate

PMIDs:
23250851

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
22970246

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

ROMIPLOSTIM Primary Drug Name

Drug Info:

Drug Class hematopoiesis stimulating agent

Year of Approval 2008

Drug Info:

Drug Indications for treatment of thrombocytopenia

Drug Class fusion protein

FDA Approval approved

Alternate Names:

D01PZD TTD Drug ID

Publications:

Mezrich JD et al., 2012, SU5416, a VEGF receptor inhibitor and ligand of the AHR, represents a new alternative for immunomodulation., PLoS One