5159 |
PLATELET DERIVED GROWTH FACTOR RECEPTOR BETA |
PDGFRB |
CD140B |
IBGC4 |
IMF1 |
JTK12 |
KOGS |
PDGFR |
PDGFR-1 |
PDGFR1 |
PENTT |
173410 |
8804 |
ENSG00000113721 |
OTTHUMG00000130053 |
P09619 |
PGFRB_HUMAN |
CD140 antigen-like family member B |
Platelet-derived growth factor receptor beta |
Beta platelet-derived growth factor receptor |
Beta-type platelet-derived growth factor receptor |
PDGFR-beta |
PDGF-R-beta |
CD_antigen=CD140b |
Platelet-derived growth factor receptor 1 |
BETA PLATELET-DERIVED GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (PDGF-R-BETA) (CD140B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P09619] |
4176 |
PA33148 |
T59102 |
Target Subclass | KInase |
Target Main Class | Receptors |
Transmembrane Helix Count | 1 |
Target Subclass | PDGFR |
Interpro Acc | IPR001245 |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | KINASE |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Status | Swiss-Prot |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
KINASE |
TYROSINE KINASE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
agonist (activating) |
Mechanism of Interaction | Platelet-derived growth factor receptor agonist |
Direct Interaction | yes |
Trial Name | becaplermin,Regranex |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Novel drug target | Established target |
Trial Name | telatinib |
Notes |
inhibitor (inhibitory) |
Notes | |
Novel drug target | Established target |
Trial Name | motesanib diphosphate, AMG 706 |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Notes | |
Trial Name | BIBF-1120,Vargatef |
Novel drug target | Established target |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | imatinib mesylate, STI 571,Gleevec, Glivec |
Novel drug target | Established target |
inhibitor (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Trial Name | axitinib, AG-013736 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | masitinib, AB1010 |
Novel drug target | Established target |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | E-10030 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Trial Name | Nexavar |
Novel drug target | Established target |
Notes |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Trial Name | dasatinib, BMS-354825,Sprycel |
n/a |
Trial Name | MP-470 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
Notes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Notes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
n/a |
Trial Name | E7080 |
Novel drug target | Established target |
inhibitor (inhibitory) |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Notes | |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | ABT-869, Linifanib |
Novel drug target | Established target |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Trial Name | dovitinib, TKI-258, CHIR-258 |
Novel drug target | Established target |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Platelet-derived growth factor receptor beta inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | Platelet-derived growth factor receptor inhibitor |
Direct Interaction | yes |
PDGFRB | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
ENSG00000113721 | Ensembl Gene Id |
PDGFRB | Gene Symbol |
PGFRB_HUMAN | Uniprot Id |
Target Subclass | KInase |
Target Main Class | Receptors |
Transmembrane Helix Count | 1 |
PLATELET-DERIVED GROWTH FACTOR RECEPTOR BETA | Uniprot Protein Name |
P09619 | Uniprot Accession |
5159 | Entrez Gene Id |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
Uniprot Evidence | 1: Evidence at protein level |
Human Readable Name | KINASE |
KINASE, DRUGGABLE GENOME |
ENSG00000113721 | Ensembl Gene Id |
BETA PLATELET-DERIVED GROWTH FACTOR RECEPTOR PRECURSOR (EC 2.7.1.112) (PDGF-R-BETA) (CD140B ANTIGEN). [SOURCE:UNIPROT/SWISSPROT;ACC:P09619] | Description |
PDGFRB | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
PDGFRB | Gene Symbol |
Target Class | Receptors |
Target Subclass | EC:2.7.10.1 |
PA33148 | PharmGKB ID |
5159 | Entrez Gene ID |
4176 | CIViC Gene ID |
CLINICALLY ACTIONABLE |
ENSG00000113721 | Gene Symbol |
PDGFRB | Ensembl Id |
DRUGGABLE GENOME |
PDGFRB | Gene Symbol |
5159 | Entrez Gene Id |
PDGFRB | MyCancerGenome Gene Symbol |
PDGFR-beta | MyCancerGenome Reported Gene Name |
PDGFR1 | GENE_SYMBOL |
PDGFRB | GENE_SYMBOL |
Platelet-derived growth factor receptor beta | UNIPROT |
5159 | OncoKB Entrez Id |
PDGFR1 | OncoKB Gene Synonym |
KOGS | OncoKB Gene Synonym |
PDGFR | GO Gene Synonym |
PDGFR1 | GO Gene Synonym |
CELL SURFACE, TYROSINE KINASE |
PDGFRB | Gene Symbol |
CLINICALLY ACTIONABLE |
5159 | Gene ID |
CD140B | dGene Synonym |
JTK12 | dGene Synonym |
KINASE, TYROSINE KINASE |
PDGFRB | TTD Gene Abbreviation |
T59102 | TTD Target ID |
Platelet-derived growth factor receptor beta | Gene Name |
P09619 | UniProt ID |
KINASE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |