DGIdb - SURAMIN Drug Record

SURAMIN chembl:CHEMBL265502 Antineoplastic

Alternate Names:

NSC-34936
SURAMIN
CI-1003
8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID
NAGANOL
BELGANYL
NAPHURIDE
SURAMINE
chembl:CHEMBL265502
rxcui:10256
pubchem.compound:5361
drugbank:04786
chemidplus:145-63-1

Drug Info:

(0 More Sources)

Publications:

Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.
Zhuang et al., 2005, Suramin promotes proliferation and scattering of renal epithelial cells., J. Pharmacol. Exp. Ther.
Rosenmüller et al., 2001, Role of phosphoinositide 3OH-kinase in autocrine transformation by PDGF-BB., J. Cell. Physiol.
Carrier et al., 1998, Evidence for distinct kinase-mediated pathways in gadd gene responses., Biochem. Pharmacol.
Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.
Liu et al., 1991, The effect of suramin, tumor necrosis factor and interferon gamma on human prostate carcinoma., J. Urol.
Bose, 2007, Follicle stimulating hormone receptor (FSHR) antagonist and epithelial ovarian cancer (EOC)., J. Exp. Ther. Oncol.
McGeary et al., 2008, Suramin: clinical uses and structure-activity relationships., Mini Rev Med Chem
Schuetz et al., 2007, Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin., Structure
Li Y et al., 2015, A FRET-based assay for screening SIRT5 specific modulators., Bioorg Med Chem Lett
Suenkel B et al., 2013, Inhibition of the human deacylase Sirtuin 5 by the indole GW5074., Bioorg Med Chem Lett
Galli U et al., 2012, Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2., Eur J Med Chem
Slusher et al., 2000, Suramin potently inhibits the enzymatic activity of PSM., Prostate
Hinek et al., 1999, Cell surface aggregation of elastin receptor molecules caused by suramin amplified signals leading to proliferation of human glioma cells., Acta Neuropathol.
Gill et al., 1998, Activation of the high affinity nerve growth factor receptor by two polyanionic chemotherapeutic agents: role in drug induced neurotoxicity., J. Neurooncol.
García J et al., 2011, Epigenetic profiling of the antitumor natural product psammaplin A and its analogues., Bioorg Med Chem

SURAMIN ST14

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590895

Sources:
NCI
SURAMIN SPINT1

Interaction Score: 4.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15590895

Sources:
NCI
SURAMIN FSHR

Interaction Score: 1.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
17552360 18991754

Sources:
TTD
SURAMIN SIRT3

Interaction Score: 1.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22835719

Sources:
DTC
SURAMIN SIRT5

Interaction Score: 1.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17355872 25818461 23195732

Sources:
DTC
SURAMIN CCNA2

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10208280

Sources:
NCI
SURAMIN MC2R

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7747311

Sources:
NCI
SURAMIN FOLH1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10861758

Sources:
NCI
SURAMIN IFNG

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1899122

Sources:
NCI
SURAMIN SIRT1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21215647

Sources:
DTC
SURAMIN HPSE

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SURAMIN DDIT3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9586958

Sources:
NCI
SURAMIN PIK3CB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15833899 11473364

Sources:
NCI
SURAMIN PIN1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN NTRK1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9874182

Sources:
NCI
SURAMIN USP2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN KMT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN TDP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN GLS

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN PIK3CA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15833899

Sources:
NCI
SURAMIN MPHOSPH8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN APEX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN FEN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN USP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN POLK

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: SURAMIN

Version: 14-September-2017

Alternate Names:

C853 NCI drug code

Drug Info:

Publications:

Heppner et al., Adrenocortical insufficiency in Rhodesian sleeping sickness is not attributable to suramin., Trans. R. Soc. Trop. Med. Hyg.

Slusher et al., 2000, Suramin potently inhibits the enzymatic activity of PSM., Prostate

Lee et al., 2005, Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells., Am. J. Physiol., Cell Physiol.

DTC: SURAMIN

Version: 02-September-2020

Alternate Names:

CHEMBL265502 ChEMBL Drug ID

Drug Info:

Publications:

Galli U et al., 2012, Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2., Eur J Med Chem

Li Y et al., 2015, A FRET-based assay for screening SIRT5 specific modulators., Bioorg Med Chem Lett

Suenkel B et al., 2013, Inhibition of the human deacylase Sirtuin 5 by the indole GW5074., Bioorg Med Chem Lett

TTD: Suramin
- Version: 2020.06.01
Alternate Names:

D0H2UB TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL265502
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

SURAMIN Drug Record

SURAMIN chembl:CHEMBL265502 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590895

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15590895

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 17552360 18991754

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22835719

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17355872 25818461 23195732

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10208280

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7747311

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10861758

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1899122

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21215647

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9586958

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15833899 11473364

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9874182

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
15590895

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15590895

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
17552360 18991754

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
22835719

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17355872 25818461 23195732

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10208280

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7747311

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10861758

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1899122

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21215647

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
9586958

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15833899 11473364

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9874182

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15833899

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found