DGIdb - KMT2A Gene Record

KMT2A 4297 Druggable GenomeClinically Actionable

Alternate Names:

4297
LYSINE METHYLTRANSFERASE 2A
KMT2A
ALL-1
CXXC7
HRX
HTRX1
MLL
MLL1
MLL1A
TRX1
WDSTS
159555
7132
ENSG00000118058
OTTHUMG00000166337
Q03164
3537
ALL1
HTRX
Histone-lysine N-methyltransferase 2A

Gene Info:

Initial Gene Query	MLL
Counted Citations from 1950-2000	229
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE
METHYL TRANSFERASE
ENZYME

Publications:

Cruickshank et al., 2017, Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin., Leukemia
Baker et al., 2016, The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia., Cancer Res.
Picaud et al., 2015, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy., Cancer Res.
Rhyasen et al., 2016, AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies., Mol. Cancer Ther.

CLODRONATE DISODIUM KMT2A

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AZD-5153 KMT2A

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type predicted – sensitive

Approval Status Preclinical - Cell line xenograft

PMIDs:
27573426

Sources:
JAX-CKB
DACINOSTAT KMT2A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Cytarabine + Dacinostat

Indication/Tumor Type acute lymphocytic leukemia

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB
NITROBLUE TETRAZOLIUM KMT2A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SINENSETIN KMT2A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OLSALAZINE KMT2A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYCLIRAMINE MALEATE KMT2A

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL591864 KMT2A

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL588234 KMT2A

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIFLUFENICAN KMT2A

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FURAFYLLINE KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PLERIXAFOR KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIRENOXINE KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL528734 KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL16751 KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMINOQUINURIDE KMT2A

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DINACICLIB KMT2A

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Preclinical

PMIDs:
26627013

Sources:
JAX-CKB
RAMATROBAN KMT2A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CETRIMONIUM BROMIDE KMT2A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TRYPAN BLUE KMT2A

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHLORHEXIDINE HYDROCHLORIDE KMT2A

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
EMETINE HYDROCHLORIDE KMT2A

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MOCETINOSTAT KMT2A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Cytarabine + Mocetinostat

Indication/Tumor Type acute lymphocytic leukemia

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB
TRACAZOLATE KMT2A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIRARUBICIN KMT2A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL582478 KMT2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1312050 KMT2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL486706 KMT2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1367933 KMT2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PANOBINOSTAT KMT2A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell culture

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB
TRIMETREXATE KMT2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL259615 KMT2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TANNIC ACID KMT2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROMIDEPSIN KMT2A

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical - Cell line xenograft

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB
METHYLENE BLUE KMT2A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TOPOTECAN HYDROCHLORIDE KMT2A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN HEXASODIUM KMT2A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1362503 KMT2A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL596633 KMT2A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL527584 KMT2A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CONGO RED KMT2A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OXIDOPAMINE HYDROCHLORIDE KMT2A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL19954 KMT2A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYTARABINE KMT2A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute lymphocytic leukemia

Response Type sensitive

Approval Status Preclinical - Cell line xenograft

PMIDs:
27443263

Sources:
JAX-CKB
PROTOPORPHYRIN KMT2A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SURAMIN KMT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AURINTRICARBOXYLIC ACID KMT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DAUNORUBICIN HYDROCHLORIDE KMT2A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOXORUBICIN KMT2A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy I-CBP112 + Doxorubicin

Indication/Tumor Type leukemia

Response Type predicted – sensitive

PMIDs:
26552700

Sources:
JAX-CKB
CHEMBL429095 KMT2A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000118058
- Version: 101_38
Alternate Names:

KMT2A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: KMT2A
- Version: February-2014
Alternate Names:

4297 Entrez Gene ID

Gene Info:

Initial Gene Query MLL

Counted Citations from 1950-2000 229

Gene Categories:

METHYL TRANSFERASE

Publications:

JAX-CKB: KMT2A

Version: 27-September-2017

Alternate Names:

4297 CKB Entrez Id

KMT2A CKB Gene Synonym

ALL-1 CKB Gene Synonym

Gene Info:

Publications:

Cruickshank et al., 2017, Systematic chemical and molecular profiling of MLL-rearranged infant acute lymphoblastic leukemia reveals efficacy of romidepsin., Leukemia

Baker et al., 2016, The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia., Cancer Res.

Picaud et al., 2015, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy., Cancer Res.

CIViC: KMT2A
- Version: 14-September-2020
Alternate Names:

4297 Entrez Gene ID

3537 CIViC Gene ID

Gene Info:

Publications:

Daigle et al., 2011, Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor., Cancer Cell
HingoraniCasas: ENSG00000118058
- Version: 31-May-2017
Alternate Names:

ENSG00000118058 Gene Symbol

KMT2A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: KMT2A
- Version: 19.3
Alternate Names:

ENSG00000118058 Ensembl Gene ID

ALL-1 Human Protein Atlas Gene Synonym

CXXC7 Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: KMT2A
- Version: 11-November-2018
Alternate Names:

KMT2A Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: KMT2A
- Version: 01-February-2022
Alternate Names:

Histone-lysine N-methyltransferase 2A Gene Name

Q03164 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
MskImpact: KMT2A
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
DTC: KMT2A
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:
FoundationOneGenes: KMT2A
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: KMT2A
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Indication/Tumor Type	acute myeloid leukemia
Response Type	predicted – sensitive
Approval Status	Preclinical - Cell line xenograft

combination therapy	Cytarabine + Dacinostat
Indication/Tumor Type	acute lymphocytic leukemia
Response Type	sensitive

combination therapy	Cytarabine + Mocetinostat
Indication/Tumor Type	acute lymphocytic leukemia
Response Type	sensitive

Evidence Type	Actionable
Approval Status	Preclinical - Cell culture
Response Type	sensitive

combination therapy	I-CBP112 + Doxorubicin
Indication/Tumor Type	leukemia
Response Type	predicted – sensitive

ENSG00000118058	Ensembl Gene ID
ALL-1	Human Protein Atlas Gene Synonym
CXXC7	Human Protein Atlas Gene Synonym

Histone-lysine N-methyltransferase 2A	Gene Name
Q03164	UniProt ID

KMT2A Gene Record

KMT2A 4297 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type acute myeloid leukemia Response Type predicted – sensitive Approval Status Preclinical - Cell line xenograft

PMIDs: 27573426

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info: combination therapy Cytarabine + Dacinostat Indication/Tumor Type acute lymphocytic leukemia Response Type sensitive

PMIDs: 27443263

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type acute myeloid leukemia Response Type sensitive Approval Status Preclinical

PMIDs: 26627013

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type predicted – sensitive

Approval Status Preclinical - Cell line xenograft

PMIDs:
27573426

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Cytarabine + Dacinostat

Indication/Tumor Type acute lymphocytic leukemia

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Preclinical

PMIDs:
26627013

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy Cytarabine + Mocetinostat

Indication/Tumor Type acute lymphocytic leukemia

Response Type sensitive

PMIDs:
27443263

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a