DGIdb - TREPROSTINIL Drug Record

TREPROSTINIL chembl:CHEMBL1237119 Approved

Alternate Names:

15AU81
15-AU-81
TREPROSTINIL
LRX-15
TYVASO
UT-15
REMODULIN
TRESPROSTINIL
ORENITRAM
[[(1R,2R,3AS,9AS)-2-HYDROXY-1-[(3S)-3-HYDROXYOCTYL]-2,3,3A,4,9,9A-HEXAHYDRO-1H-CYCLOPENTA[B]NAPHTALEN-5-YL]OXY]ACETIC ACID
TREPROSTINILO
TYVASO®
(1R,2R,3AS,9AS)-[[2,3,3A,4,9,9A-HEXAHYDRO-2-HYDROXY- 1-[(3S)-3-HYDROXYOCTYL]-1H-BENZ[F]INDEN-5-YL] OXY]ACETIC ACID
UNIPROST
TREPROSTINILUM
REMODULIN®
chembl:CHEMBL1237119
rxcui:343048
drugbank:00374
chemidplus:81846-19-7
pubchem.compound:6918140

Drug Info:

Drug Class	antihypertensive agents
Year of Approval	2002
Drug Class	antithrombotic agents
FDA Approval	2002
Drug Class	small molecule
Drug Indications	Antithrombotic Agents
Drug Indications	Antihypertensive Agents

(1 More Sources)

Publications:

Sprague et al., 2008, Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes., Microcirculation
Olschewski et al., 2004, Prostacyclin and its analogues in the treatment of pulmonary hypertension., Pharmacol. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Falcetti et al., 2010, Smooth muscle proliferation and role of the prostacyclin (IP) receptor in idiopathic pulmonary arterial hypertension., Am. J. Respir. Crit. Care Med.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Bacha NC et al., 2019, Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension., Pediatr Pulmonol

TREPROSTINIL PTGIR

Interaction Score: 10.3

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

PMIDs:
18574748 15163595 11752352 20622039

Sources:
ChemblInteractions TTD
TREPROSTINIL P2RY12

Interaction Score: 7.36

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 30485728

Sources:
TdgClinicalTrial TEND
TREPROSTINIL PPARG

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

TEND: TREPROSTINIL
- Version: 01-August-2011
Alternate Names:

TREPROSTINIL Primary Drug Name

Drug Info:

Drug Class antithrombotic agents

Year of Approval 2002

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: TREPROSTINIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antithrombotic Agents

Drug Class small molecule

Publications:
TTD: Treprostinil
- Version: 2020.06.01
Alternate Names:

D01WUA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1237119
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1237119
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Prostanoid IP receptor agonist
Direct Interaction	yes

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

TREPROSTINIL Drug Record

TREPROSTINIL chembl:CHEMBL1237119 Approved

Alternate Names:

Drug Info:

Publications:

TREPROSTINIL PTGIR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Prostanoid IP receptor agonist Direct Interaction yes

PMIDs: 18574748 15163595 11752352 20622039

Sources: ChemblInteractions TTD

TREPROSTINIL P2RY12

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 30485728

Sources: TdgClinicalTrial TEND

TREPROSTINIL PPARG

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TEND

TEND: TREPROSTINIL

Alternate Names: TREPROSTINIL Primary Drug Name

Drug Info: Drug Class antithrombotic agents Year of Approval 2002 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: TREPROSTINIL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Antithrombotic Agents Drug Class small molecule

Publications:

TTD: Treprostinil

Alternate Names: D01WUA TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1237119

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1237119

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

PMIDs:
18574748 15163595 11752352 20622039

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 30485728

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TEND

Alternate Names:

TREPROSTINIL Primary Drug Name

Drug Info:

Drug Class antithrombotic agents

Year of Approval 2002

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Antithrombotic Agents

Drug Class small molecule

Alternate Names:

D01WUA TTD Drug ID