2902 |
GLUTAMATE IONOTROPIC RECEPTOR NMDA TYPE SUBUNIT 1 |
GRIN1 |
GluN1 |
MRD8 |
NMD-R1 |
NMDA1 |
NMDAR1 |
NR1 |
138249 |
4584 |
ENSG00000176884 |
OTTHUMG00000020976 |
NMDZ1_HUMAN |
Q05586 |
N-methyl-D-aspartate receptor subunit NR1 |
Glutamate [NMDA] receptor subunit zeta-1 |
Glutamate receptor ionotropic, NMDA 1 |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR (N-METHYL-D- ASPARTATE RECEPTOR SUBUNIT NR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05586] |
Q12879 |
GRIN2A |
PA28978 |
Glutamate receptor ionotropic NMDA 1 |
T62276 |
NDHMSD |
NDHMSR |
Human Readable Name | DRUGGABLE GENOME |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001320 |
Interpro Name | Ionotropic glutamate receptor |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Short Name | Iontro_glu_rcpt |
Transmembrane Helix Count | 3 |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Glutamate |
Target Subclass | Channels |
Target Main Class | Receptors |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
Target Subclass | TC:1.A.10.1.6 |
Gene Biotype | PROTEIN_CODING |
CELL SURFACE |
ION CHANNEL |
DRUGGABLE GENOME |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | - |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate NMDA receptor; GRIN1/GRIN2B antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate NMDA receptor; GRIN1/GRIN2B antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate NMDA receptor; GRIN1/GRIN2B antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate NMDA receptor; GRIN1/GRIN2B antagonist |
n/a |
Trial Name | neramexane mesylate |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
partial agonist (activating) |
Novel drug target | Established target |
Trial Name | GLYX-13 |
Mechanism of Interaction | Glutamate [NMDA] receptor partial agonist |
blocker (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor blocker |
Direct Interaction | yes |
Trial Name | AZD-6765 |
n/a |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
Direct Interaction | yes |
Trial Name | AM-101 |
blocker (inhibitory) |
Trial Name | CNS-5161 |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate [NMDA] receptor blocker |
n/a |
Trial Name | dimiracetam, NT-11624 |
Novel drug target | Established target |
antagonist (inhibitory) |
Novel drug target | Established target |
Trial Name | V3381 |
Direct Interaction | yes |
antagonist (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
n/a |
Trial Name | dexanabinol, HU-211 |
Novel drug target | Established target |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
n/a |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
Direct Interaction | yes |
n/a |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor negative allosteric modulator |
n/a |
Trial Name | Dimebon |
Novel drug target | Established target |
positive modulator (activating) |
Mechanism of Interaction | Glutamate [NMDA] receptor positive allosteric modulator |
Direct Interaction | yes |
partial agonist (activating) |
Mechanism of Interaction | Glutamate [NMDA] receptor partial agonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
antagonist (inhibitory) |
Mechanism of Interaction | Glutamate [NMDA] receptor antagonist |
Direct Interaction | yes |
GRIN1 | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
GRIN1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1.6 |
Q05586 | Uniprot Accession |
GRIN1 | Gene Symbol |
2902 | Entrez Gene Id |
Transmembrane Helix Count | 3 |
Target Subclass | Ligand_gated_ion_channels |
Target Subclass | Glutamate |
ENSG00000176884 | Ensembl Gene Id |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA 1 PRECURSOR (N-METHYL-D- ASPARTATE RECEPTOR SUBUNIT NR1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q05586] | Description |
GRIN1 | Display Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
GRIN1 | Uniprot Gene Name |
GLUTAMATE [NMDA] RECEPTOR SUBUNIT ZETA-1 | Uniprot Protein Name |
2902 | Entrez Gene Id |
Interpro Type | Domain |
Uniprot Status | Swiss-Prot |
Interpro Acc | IPR001320 |
DRUGGABLE GENOME |
GRIN2A | Gene Symbol |
GRIN1 | Gene Symbol |
Target Class | Receptors |
Target Subclass | TC:1.A.10.1 |
PA28978 | PharmGKB ID |
NMDAR1 | GENE_SYMBOL |
GRIN1 | GENE_SYMBOL |
Glutamate receptor ionotropic, NMDA 1 | UNIPROT |
ENSG00000176884 | Gene Symbol |
GRIN1 | Ensembl Id |
DRUGGABLE GENOME |
NMDAR1 | GO Gene Synonym |
CELL SURFACE |
NMDAR1 | TTD Gene Abbreviation |
T62276 | TTD Target ID |
Glutamate receptor ionotropic, NMDA 1 | Gene Name |
Q05586 | UniProt ID |
ION CHANNEL |