DGIdb - ORPHENADRINE Drug Record

ORPHENADRINE chembl:CHEMBL900 Approved

Alternate Names:

ORPHENADRINE
DISIPAL
INVAGESIC
NORFLEX
ORPHENGESIC
MEFENAMINE
NORGESIC
N,N-DIMETHYL-2-[(O-METHYL-ALPHA-PHENYLBENZYL)OXY]ETHYLAMINE
2-(PHENYL-O-TOLYLMETHOXY)ETHYLDIMETHYLAMINE
PHENYL-O-TOLYLMETHYL DIMETHYAMINOETHYL ETHER
DIMETHYL-[2-(PHENYL-O-TOLYL-METHOXY)-ETHYL]-AMINE
N,N-DIMETHYL-2-(PHENYL(O-TOLYL)METHOXY)ETHANAMINE
BETA-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER
O-MONOMETHYLDIPHENHYDRAMINE
ORFENADRINA
Β-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER
O-METHYLDIPHENHYDRAMINE
N,N-DIMETHYL-2-(ALPHA-2-TOLYLBENZOYLOXY)ETHYLAMINE
INVAGESIC®
2-METHYLDIPHENHYDRAMINE
ORPHENADRINUM
rxcui:7715
chembl:CHEMBL900
drugbank:01173
chemidplus:83-98-7
pubchem.compound:4601

Drug Info:

Drug Class	muscle relaxants, central
Year of Approval	1957
Drug Class	antiparkinson agents
FDA Approval	1957
Drug Class	small molecule
Drug Indications	Muscle Relaxants, Central
Drug Indications	Antiparkinson Agents

(0 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Kornhuber et al., 1995, Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies., J. Neural Transm. Gen. Sect.
Rumore et al., 1985, Analgesic effects of antihistaminics., Life Sci.

ORPHENADRINE GRIN3B

Interaction Score: 2.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
ORPHENADRINE GRIN2D

Interaction Score: 2.47

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
ORPHENADRINE GRIN3A

Interaction Score: 2.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
ORPHENADRINE GRIN1

Interaction Score: 1.51

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND
ORPHENADRINE HRH1

Interaction Score: 0.49

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 2578597

Sources:
TdgClinicalTrial TEND

TEND: ORPHENADRINE
- Version: 01-August-2011
Alternate Names:

ORPHENADRINE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval 1957

Drug Class muscle relaxants, central

Publications:
TdgClinicalTrial: ORPHENADRINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antiparkinson Agents

Drug Indications Muscle Relaxants, Central

Drug Class small molecule

Publications:
TTD: Orphenadrine
- Version: 2020.06.01
Alternate Names:

D0D9FV TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL900
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

Novel drug target	Established target
Trial Name	-

ORPHENADRINE Drug Record

ORPHENADRINE chembl:CHEMBL900 Approved

Alternate Names:

Drug Info:

Publications:

ORPHENADRINE GRIN3B

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

ORPHENADRINE GRIN2D

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

ORPHENADRINE GRIN3A

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

ORPHENADRINE GRIN1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 8788072

Sources: TdgClinicalTrial TEND

ORPHENADRINE HRH1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17016423 17139284 2578597

Sources: TdgClinicalTrial TEND

TEND: ORPHENADRINE

Alternate Names: ORPHENADRINE Primary Drug Name

Drug Info: Drug Class antiparkinson agents Year of Approval 1957 Drug Class muscle relaxants, central

Publications:

TdgClinicalTrial: ORPHENADRINE

Alternate Names:

Drug Info: Drug Indications Antiparkinson Agents Drug Indications Muscle Relaxants, Central Drug Class small molecule

Publications:

TTD: Orphenadrine

Alternate Names: D0D9FV TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL900

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 8788072

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17016423 17139284 2578597

Sources:
TdgClinicalTrial TEND

Alternate Names:

ORPHENADRINE Primary Drug Name

Drug Info:

Drug Class antiparkinson agents

Year of Approval 1957

Drug Class muscle relaxants, central

Drug Info:

Drug Indications Antiparkinson Agents

Drug Indications Muscle Relaxants, Central

Drug Class small molecule

Alternate Names:

D0D9FV TTD Drug ID