GUCY1A2 Gene Record

  • RIOCIGUAT   GUCY1A2

    Interaction Score: 7.07

    Interaction Types & Directionality:
    activator (activating)
    positive modulator (activating)
    agonist (activating)
    stimulator (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name riociguat, BAY-63-2521
    Mechanism of Interaction Soluble guanylate cyclase positive allosteric modulator

    PMIDs:
    22044316 26219978


    Sources:
    TdgClinicalTrial ChemblInteractions

  • NAPROXCINOD   GUCY1A2

    Interaction Score: 2.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Naproxcinod
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • ISOSORBIDE DINITRATE   GUCY1A2

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SODIUM NITROPRUSSIDE   GUCY1A2

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITRIC OXIDE   GUCY1A2

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOSORBIDE MONONITRATE   GUCY1A2

    Interaction Score: 1.77

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITROGLYCERIN   GUCY1A2

    Interaction Score: 0.88

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000152402

    • Version: 101_38

    Alternate Names:
    GUCY1A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000152402

    • Version: 26-July-2011

    Alternate Names:
    GUCY1A2 Display Id
    ENSG00000152402 Ensembl Gene Id
    GUANYLATE CYCLASE SOLUBLE, ALPHA-2 CHAIN (EC 4.6.1.2) (GCS-ALPHA-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P33402] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P33402

    • Version: January-2014

    Alternate Names:
    GUCY1A2 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.6.1.2

    Publications:

  • HopkinsGroom: P33402

    • Version: 11-September-2012

    Alternate Names:
    ENSG00000152402 Ensembl Gene Id
    GCYA2_HUMAN Uniprot Id
    P33402 Uniprot Accession

    Gene Info:
    Interpro Type Domain
    Interpro Acc IPR001054
    Uniprot Status Swiss-Prot

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000152402

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000152402 Gene Symbol
    GUCY1A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GUC1A2

    • Version: chembl_23

    Alternate Names:
    GUCSA2 GENE_SYMBOL
    GUCY1A2 GENE_SYMBOL
    Guanylate cyclase soluble subunit alpha-2 UNIPROT

    Gene Info:

    Publications:

  • Pharos: GUCY1A2

    • Version: 01-February-2022

    Alternate Names:
    Guanylate cyclase soluble subunit alpha-2 Gene Name
    P33402 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications: