DGIdb - NITROGLYCERIN Drug Record

NITROGLYCERIN chembl:CHEMBL730 ApprovedAntineoplastic

Alternate Names:

DEPONIT 10
TRINITRIN TABLETS
NITRIDERM TTS
GLYCERYL TRINITRATE
NITRO-BID
DILUTED NITROGLYCERIN
NITROCONTIN CONTINUS
MINITRAN 5
NITROMIN
TRINTEK 15
MINITRAN 15
SUSTAC
NITROSTAT
NITRONAL
NITROGLYCERIN TABLETS
RECTIV
GLYTRIN
GONITRO
DEPONIT 5
RECTOGESIC
NITROL
NITROCINE
NATIROSE
TRINTEK 5
NITRO IV
LENITRAL 7.5
TRANSIDERM-NITRO 5
NITROGLYCERIN
TRANSIDERM-NITRO 10
NITROLINGUAL
NITROLINGUAL PUMPSPRAY
MINITRAN 10
MINITRAN
SUSCARD BUCCAL
CORO-NITRO
C01DA02
PERCUTOL
NITRO-DUR
TRANSDERM-NITRO
TRINTEK 10
NITROMIST
TRIDIL
NITRO-MACK RET
NITROGLYCEROL
TRINITROGLYCERIN
1,2,3-PROPANETRIYL NITRATE
TRINITROGLYCEROL
GLYCEROL TRINITRATE
1,2,3-PROPANETRIOLTRINITRATE
PROPANE-1,2,3-TRIYL TRINITRATE
GLYCEROLTRINITRAT
NITROMED
GLYCEROL, NITRIC ACID TRIESTER
GLYCERIN TRINITRATE
RECTOGESIC®
GLYCEROLI TRINITRATIS
MINITRAN®
GLYTRIN®
NITROGLYCERINE
NATISPRAY
TRINITRINE
EPINITRIL
NG
NITROGLICERINA
pubchem.compound:4510
rxcui:4917
chembl:CHEMBL730
chemidplus:55-63-0

Drug Info:

Drug Class	vasodilator agents
Year of Approval	approved before 1982
Drug Class	antianginal agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of Raynaud's disease

(3 More Sources)

Publications:

Tsuchida et al., 1990, Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms., J. Biol. Chem.
Iliodromitis et al., 2006, Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning., Basic Res. Cardiol.
Bauersachs, 2009, Aminoethyl nitrate--the novel super nitrate?, Br. J. Pharmacol.
Madhani et al., 2003, Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling., Br. J. Pharmacol.
Tamano et al., 1996, Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats., Carcinogenesis

NITROGLYCERIN NPR1

Interaction Score: 3.09

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MQX-503, nitroglycerin 0.9% topical cream,Vascana

Novel drug target Established target

PMIDs:
19732062 12890708

Sources:
TdgClinicalTrial TEND
NITROGLYCERIN GUCY1B2

Interaction Score: 1.03

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NITROGLYCERIN GUCY1A1

Interaction Score: 1.03

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Soluble guanylate cyclase activator

PMIDs:
None found

Sources:
ChemblInteractions
NITROGLYCERIN GUCY1A2

Interaction Score: 0.88

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NITROGLYCERIN GUCY1B1

Interaction Score: 0.88

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
NITROGLYCERIN GSTM1

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2110160

Sources:
NCI
NITROGLYCERIN HRAS

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8968066

Sources:
NCI
NITROGLYCERIN MAPK3

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16612556

Sources:
NCI
NITROGLYCERIN HIF1A

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial
NITROGLYCERIN EGFR

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: NITROGLYCERIN
- Version: 01-August-2011
Alternate Names:

NITROGLYCERIN Primary Drug Name

Drug Info:

Drug Class antianginal agents

Year of Approval approved before 1982

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: NITROGLYCERIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of Raynaud's disease

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: NITROGLYCERIN

Version: 14-September-2017

Alternate Names:

C29294 NCI drug code

Drug Info:

Publications:

Tamano et al., 1996, Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats., Carcinogenesis

Tsuchida et al., 1990, Purification and characterization of glutathione transferases with an activity toward nitroglycerin from human aorta and heart. Multiplicity of the human class Mu forms., J. Biol. Chem.

Iliodromitis et al., 2006, Differential activation of mitogen-activated protein kinases in ischemic and nitroglycerin-induced preconditioning., Basic Res. Cardiol.

TTD: Nitroglycerin
- Version: 2020.06.01
Alternate Names:

D07YDE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL730
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: NITROGLYCERIN
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL730
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	MQX-503, nitroglycerin 0.9% topical cream,Vascana
Novel drug target	Established target

Mechanism of Interaction	Soluble guanylate cyclase activator
Direct Interaction	yes

NITROGLYCERIN Drug Record

NITROGLYCERIN chembl:CHEMBL730 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name MQX-503, nitroglycerin 0.9% topical cream,Vascana Novel drug target Established target

PMIDs: 19732062 12890708

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Soluble guanylate cyclase activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: activator (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Soluble guanylate cyclase activator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Soluble guanylate cyclase activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Soluble guanylate cyclase activator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2110160

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8968066

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16612556

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenomeClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

TEND: NITROGLYCERIN

Alternate Names: NITROGLYCERIN Primary Drug Name

Drug Info: Drug Class antianginal agents Year of Approval approved before 1982 Drug Class vasodilator agents

Publications:

TdgClinicalTrial: NITROGLYCERIN

Alternate Names:

Drug Info: Drug Indications for treatment of Raynaud's disease Drug Class Small Molecule FDA Approval approved

Publications:

NCI: NITROGLYCERIN

Alternate Names: C29294 NCI drug code

Drug Info:

TTD: Nitroglycerin

Alternate Names: D07YDE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL730

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: NITROGLYCERIN

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL730

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name MQX-503, nitroglycerin 0.9% topical cream,Vascana

Novel drug target Established target

PMIDs:
19732062 12890708

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Soluble guanylate cyclase activator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Soluble guanylate cyclase activator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
2110160

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8968066

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16612556

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenomeClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

NITROGLYCERIN Primary Drug Name

Drug Info:

Drug Class antianginal agents

Year of Approval approved before 1982

Drug Class vasodilator agents

Drug Info:

Drug Indications for treatment of Raynaud's disease

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29294 NCI drug code

Alternate Names:

D07YDE TTD Drug ID