GUCY1B1 Gene Record

  • GUCY1B1 2983 Druggable Genome

    Alternate Names:

    2983
    GUANYLATE CYCLASE 1 SOLUBLE SUBUNIT BETA
    GUCY1B3
    GC-S-beta-1
    GC-SB3
    GUC1B3
    GUCB3
    GUCSB3
    GUCY1B1
    139397
    4687
    ENSG00000061918
    OTTHUMG00000161698
    Q02153
    GCYB1_HUMAN
    GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1
    GUANYLATE CYCLASE SOLUBLE, BETA-1 CHAIN (EC 4.6.1.2) (GCS-BETA-1) (SOLUBLE GUANYLATE CYCLASE SMALL SUBUNIT) (GCS-BETA-3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02153]
    GCS-beta-3
    GCS-beta-1
    Soluble guanylate cyclase small subunit
    Guanylate cyclase soluble subunit beta-3
    Guanylate cyclase soluble beta-1
    T61581
    guanylate cyclase 1 soluble subunit beta 1

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR001054
    Interpro Type Domain
    Interpro Short Name A/G_cyclase
    Target Class Enzymes
    Target Subclass EC:4.6.1.2
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

  • CINACIGUAT   GUCY1B1

    Interaction Score: 8.83

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • RIOCIGUAT   GUCY1B1

    Interaction Score: 3.53

    Interaction Types & Directionality:
    activator (activating)
    positive modulator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase positive allosteric modulator
    Direct Interaction yes
    Novel drug target Novel Target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • ISOSORBIDE DINITRATE   GUCY1B1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITRIC OXIDE   GUCY1B1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SODIUM NITROPRUSSIDE   GUCY1B1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOSORBIDE MONONITRATE   GUCY1B1

    Interaction Score: 1.77

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Soluble guanylate cyclase activator

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • NITROGLYCERIN   GUCY1B1

    Interaction Score: 0.88

    Interaction Types & Directionality:
    activator (activating)

    Interaction Info:
    Mechanism of Interaction Soluble guanylate cyclase activator
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • Ensembl: ENSG00000061918

    • Version: 101_38

    Alternate Names:
    GUCY1B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: Q02153

    • Version: January-2014

    Alternate Names:
    GUCY1B3 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:4.6.1.2

    Publications:

  • RussLampel: ENSG00000061918

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000061918 Ensembl Gene Id
    GUCY1B3 Display Id
    GUANYLATE CYCLASE SOLUBLE, BETA-1 CHAIN (EC 4.6.1.2) (GCS-BETA-1) (SOLUBLE GUANYLATE CYCLASE SMALL SUBUNIT) (GCS-BETA-3). [SOURCE:UNIPROT/SWISSPROT;ACC:Q02153] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: Q02153

    • Version: 11-September-2012

    Alternate Names:
    Q02153 Uniprot Accession
    GCYB1_HUMAN Uniprot Id
    GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-1 Uniprot Protein Name

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Adenylyl cyclase class-3/4/guanylyl cyclase
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HingoraniCasas: ENSG00000061918

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000061918 Gene Symbol
    GUCY1B3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: GUC1B3

    • Version: chembl_23

    Alternate Names:
    GUCSB3 GENE_SYMBOL
    GUCY1B1 GENE_SYMBOL
    GUCY1B3 GENE_SYMBOL

    Gene Info:

    Publications:

  • TTD: Guanylate cyclase soluble beta-1

    • Version: 2020.06.01

    Alternate Names:
    GUCY1B1 TTD Gene Abbreviation
    T61581 TTD Target ID

    Gene Info:

    Publications: