DGIdb - KCNK2 Gene Record

KCNK2 3776 Druggable Genome

Alternate Names:

3776
POTASSIUM TWO PORE DOMAIN CHANNEL SUBFAMILY K MEMBER 2
KCNK2
K2p2.1
TPKC1
TREK
TREK-1
TREK1
hTREK-1c
hTREK-1e
603219
6277
ENSG00000082482
OTTHUMG00000037017
O95069
KCNK2_HUMAN
TREK-1 K(+) channel subunit
Two pore potassium channel TPKC1
Outward rectifying potassium channel protein TREK-1
Potassium channel subfamily K member 2
Two pore domain potassium channel TREK-1

Gene Info:

Initial Gene Query	K2p2.1
Counted Citations from 1950-2000	251
Target Class	Transporters
Target Subclass	TC:1.A.1.8
Target Subclass	Two-p_K_channels
Transmembrane Helix Count	6
Target Subclass	Voltage_gated_ion_channels
Target Subclass	Channels
Target Main Class	Transporters
Gene Biotype	PROTEIN_CODING

(5 More Sources)

Gene Categories: Category Details

CELL SURFACE
ION CHANNEL
DRUGGABLE GENOME

Publications:

Roukoz et al., 2007, Dofetilide: a new class III antiarrhythmic agent., Expert Rev Cardiovasc Ther
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Rodrigues N et al., 2014, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem

CHEMBL73820 KCNK2

Interaction Score: 17.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24561669

Sources:
DTC
DOFETILIDE KCNK2

Interaction Score: 4.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17187453 17016423 17139284

Sources:
TdgClinicalTrial TEND
HALOTHANE KCNK2

Interaction Score: 0.32

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOFLURANE KCNK2

Interaction Score: 0.32

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DESFLURANE KCNK2

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENFLURANE KCNK2

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SEVOFLURANE KCNK2

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Ensembl: ENSG00000082482
- Version: 101_38
Alternate Names:

KCNK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
BaderLabGenes: KCNK2
- Version: February-2014
Alternate Names:

3776 Entrez Gene ID

Gene Info:

Initial Gene Query K2p2.1

Counted Citations from 1950-2000 251

Gene Categories:

ION CHANNEL

Publications:
TEND: O95069
- Version: 01-August-2011
Alternate Names:

3776 Entrez Gene Id

KCNK2_HUMAN Uniprot Id

O95069 Uniprot Accession

Gene Info:

Target Subclass Two-p_K_channels

Transmembrane Helix Count 6

Target Subclass Voltage_gated_ion_channels

Publications:
TdgClinicalTrial: O95069
- Version: January-2014
Alternate Names:

KCNK2 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.8

Publications:
DTC: KCNK2
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Rodrigues N et al., 2014, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem
ChemblInteractions: TREK
- Version: chembl_23
Alternate Names:

TREK1 GENE_SYMBOL

KCNK2 GENE_SYMBOL

Potassium channel subfamily K member 2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000082482
- Version: 31-May-2017
Alternate Names:

ENSG00000082482 Gene Symbol

KCNK2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: KCNK2
- Version: 01-February-2022
Alternate Names:

TREK GO Gene Synonym

TREK1 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE

Publications:
Pharos: KCNK2
- Version: 01-February-2022
Alternate Names:

Potassium channel subfamily K member 2 Gene Name

O95069 UniProt ID

Gene Info:

Gene Categories:

ION CHANNEL

Publications:

Mechanism of Interaction	Potassium channel subfamily K member 2 opener
Direct Interaction	yes

3776	Entrez Gene Id
KCNK2_HUMAN	Uniprot Id
O95069	Uniprot Accession

TREK1	GENE_SYMBOL
KCNK2	GENE_SYMBOL
Potassium channel subfamily K member 2	UNIPROT

Potassium channel subfamily K member 2	Gene Name
O95069	UniProt ID

Trial Name	-
Novel drug target	Established target

KCNK2 Gene Record

KCNK2 3776 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL73820 KCNK2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24561669

Sources: DTC

DOFETILIDE KCNK2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 17187453 17016423 17139284

Sources: TdgClinicalTrial TEND

HALOTHANE KCNK2

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ISOFLURANE KCNK2

Interaction Types & Directionality: activator (activating)

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DESFLURANE KCNK2

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ENFLURANE KCNK2

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

SEVOFLURANE KCNK2

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel subfamily K member 2 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Ensembl: ENSG00000082482

Alternate Names: KCNK2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

BaderLabGenes: KCNK2

Alternate Names: 3776 Entrez Gene ID

Gene Info: Initial Gene Query K2p2.1 Counted Citations from 1950-2000 251

Gene Categories: ION CHANNEL

Publications:

TEND: O95069

Alternate Names: 3776 Entrez Gene Id KCNK2_HUMAN Uniprot Id O95069 Uniprot Accession

Gene Info: Target Subclass Two-p_K_channels Transmembrane Helix Count 6 Target Subclass Voltage_gated_ion_channels

Publications:

TdgClinicalTrial: O95069

Alternate Names: KCNK2 Gene Symbol

Gene Info: Target Class Transporters Target Subclass TC:1.A.1.8

Publications:

DTC: KCNK2

Alternate Names:

Gene Info:

Publications: Rodrigues N et al., 2014, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem

ChemblInteractions: TREK

Alternate Names: TREK1 GENE_SYMBOL KCNK2 GENE_SYMBOL Potassium channel subfamily K member 2 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000082482

Alternate Names: ENSG00000082482 Gene Symbol KCNK2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: KCNK2

Alternate Names: TREK GO Gene Synonym TREK1 GO Gene Synonym

Gene Info:

Gene Categories: CELL SURFACE

Publications:

Pharos: KCNK2

Alternate Names: Potassium channel subfamily K member 2 Gene Name O95069 UniProt ID

Gene Info:

Gene Categories: ION CHANNEL

Interaction Types & Directionality:

n/a

PMIDs:
24561669

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
17187453 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel subfamily K member 2 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

KCNK2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

3776 Entrez Gene ID

Gene Info:

Initial Gene Query K2p2.1

Counted Citations from 1950-2000 251

Gene Categories:

ION CHANNEL

Alternate Names:

3776 Entrez Gene Id

KCNK2_HUMAN Uniprot Id

O95069 Uniprot Accession

Gene Info:

Target Subclass Two-p_K_channels

Transmembrane Helix Count 6

Target Subclass Voltage_gated_ion_channels

Alternate Names:

KCNK2 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass TC:1.A.1.8

Publications:

Rodrigues N et al., 2014, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem

Alternate Names:

TREK1 GENE_SYMBOL

KCNK2 GENE_SYMBOL

Potassium channel subfamily K member 2 UNIPROT

Alternate Names:

ENSG00000082482 Gene Symbol

KCNK2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TREK GO Gene Synonym

TREK1 GO Gene Synonym

Gene Categories:

CELL SURFACE

Alternate Names:

Potassium channel subfamily K member 2 Gene Name

O95069 UniProt ID

Gene Categories:

ION CHANNEL