DGIdb - MCL1 Gene Record

MCL1 4170 Druggable GenomeClinically Actionable

Alternate Names:

4170
MCL1, BCL2 FAMILY APOPTOSIS REGULATOR
MCL1
BCL2L3
EAT
MCL1-ES
MCL1L
MCL1S
Mcl-1
TM
bcl2-L-3
mcl1/EAT
159552
6943
ENSG00000143384
OTTHUMG00000034867
Q07820
INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1
MCL1_HUMAN
INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07820]
BCL-2-RELATED PROTEIN EAT/MCL1
Bcl-2-like protein 3
MCL1 apoptosis regulator, BCL2 family member
T14912

Gene Info:

Interpro Acc	IPR000712
Interpro Short Name	Bcl2_BH
Interpro Type	Domain
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Name	Apoptosis regulator, Bcl-2, BH
Human Readable Name	DRUGGABLE GENOME
Target Class	Transporters
Target Subclass	regulator of apoptosis
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Wacheck et al., 2006, Mcl-1 is a relevant molecular target for antisense oligonucleotide strategies in gastric cancer cells., Cancer Biol. Ther.
Goldwasser et al., 1996, Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines., Oncol. Res.
Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem
Gauthier et al., 2001, Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathways., J. Cell. Biochem.
Loberg RD et al., 2007, In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration., Neoplasia
Wei et al., 2006, Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance., Cancer Cell
Ando et al., 1998, EAT/mcl-1, a member of the bcl-2 related genes, confers resistance to apoptosis induced by cis-diammine dichloroplatinum (II) via a p53-independent pathway., Jpn. J. Cancer Res.
Iglesias-Serret et al., 2003, Transcriptional and translational control of Mcl-1 during apoptosis., Arch. Biochem. Biophys.
Khan et al., 2004, Analysis of histone deacetylase inhibitor, depsipeptide (FR901228), effect on multiple myeloma., Br. J. Haematol.

AZD-5991 MCL1

Interaction Score: 1.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL591135 MCL1

Interaction Score: 1.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOSORBIDE MCL1

Interaction Score: 0.88

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AT-101

Novel drug target Novel Target

PMIDs:
18084610

Sources:
TdgClinicalTrial
CHEMBL605959 MCL1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL605747 MCL1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1510164 MCL1

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1364172 MCL1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OBATOCLAX MCL1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHEMBL1543865 MCL1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OBATOCLAX MESYLATE MCL1

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ROSMARINIC ACID MCL1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
AMENTOFLAVONE MCL1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CAMPTOTHECIN MCL1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8938795 22386982

Sources:
DTC NCI
CHEMBL599255 MCL1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ROMIDEPSIN MCL1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15059137

Sources:
NCI
ALTENUSIN MCL1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL484640 MCL1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL458328 MCL1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOKAEMPFERIDE MCL1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL116548 MCL1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL602969 MCL1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL599013 MCL1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL175266 MCL1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LOMOFUNGIN MCL1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1519374 MCL1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SULFURETIN MCL1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ASTERRIC ACID MCL1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL19954 MCL1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
APOMORPHINE HYDROCHLORIDE HEMIHYDRATE MCL1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEPHALOCHROMIN MCL1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
MORIN MCL1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROCHLORPERAZINE MCL1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL1601846 MCL1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
BITHIONOL MCL1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
INSULIN MCL1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11527158

Sources:
NCI
HAEMATOXYLIN MCL1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SIROLIMUS MCL1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17010674

Sources:
NCI
ELLAGIC ACID MCL1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LIOTHYRONINE SODIUM MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL592124 MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
OMEPRAZOLE MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ASPIRIN MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12941295

Sources:
NCI
PURPUROGALLIN MCL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOCETAXEL MCL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16969094

Sources:
NCI
CARBOPLATIN MCL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10081494

Sources:
NCI
HEXACHLOROPHENE MCL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MCL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000143384
- Version: 101_38
Alternate Names:

MCL1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000143384
- Version: 26-July-2011
Alternate Names:

ENSG00000143384 Ensembl Gene Id

MCL1 Display Id

INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07820] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: Q07820
- Version: January-2014
Alternate Names:

MCL1 Gene Symbol

Gene Info:

Target Class Transporters

Target Subclass regulator of apoptosis

Publications:
HopkinsGroom: Q07820
- Version: 11-September-2012
Alternate Names:

4170 Entrez Gene Id

MCL1 Uniprot Gene Name

ENSG00000143384 Ensembl Gene Id

Gene Info:

Interpro Acc IPR000712

Interpro Short Name Bcl2_BH

Interpro Type Domain

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: MCL1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Goldwasser et al., 1996, Differential GADD45, p21CIP1/WAF1, MCL-1 and topoisomerase II gene induction and secondary DNA fragmentation after camptothecin-induced DNA damage in two mutant p53 human colon cancer cell lines., Oncol. Res.

Gauthier et al., 2001, Differential sensitivity to apoptosis between the human small and large intestinal mucosae: linkage with segment-specific regulation of BCL-2 homologs and involvement of signaling pathways., J. Cell. Biochem.

Wei et al., 2006, Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance., Cancer Cell

DTC: MCL1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Rajule R et al., 2012, Perturbing pro-survival proteins using quinoxaline derivatives: a structure-activity relationship study., Bioorg Med Chem
HingoraniCasas: ENSG00000143384
- Version: 31-May-2017
Alternate Names:

ENSG00000143384 Gene Symbol

MCL1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: BCL2L3
- Version: chembl_23
Alternate Names:

BCL2L3 GENE_SYMBOL

MCL1 GENE_SYMBOL

Induced myeloid leukemia cell differentiation protein Mcl-1 UNIPROT

Gene Info:

Publications:
Tempus: MCL1
- Version: 11-November-2018
Alternate Names:

MCL1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
TTD: Induced myeloid leukemia cell differentiation protein Mcl-1
- Version: 2020.06.01
Alternate Names:

MCL1 TTD Gene Abbreviation

T14912 TTD Target ID

Gene Info:

Publications:
MskImpact: MCL1
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: MCL1
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: MCL1
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Mechanism of Interaction	Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor
Direct Interaction	yes

ENSG00000143384	Ensembl Gene Id
MCL1	Display Id
INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN MCL-1. [SOURCE:UNIPROT/SWISSPROT;ACC:Q07820]	Description

4170	Entrez Gene Id
MCL1	Uniprot Gene Name
ENSG00000143384	Ensembl Gene Id

BCL2L3	GENE_SYMBOL
MCL1	GENE_SYMBOL
Induced myeloid leukemia cell differentiation protein Mcl-1	UNIPROT

Trial Name	AT-101
Novel drug target	Novel Target

MCL1 Gene Record

MCL1 4170 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Trial Name AT-101 Novel drug target Novel Target

PMIDs: 18084610

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8938795 22386982

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15059137

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name AT-101

Novel drug target Novel Target

PMIDs:
18084610

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
8938795 22386982

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
15059137

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC