DGIdb - GOSSYPOL Drug Record

GOSSYPOL chembl:CHEMBL51483

Alternate Names:

(-)-GOSSYPOL
BL-193
NSC-624336
GOSSYPOL
NSC-56817

Drug Info:

(0 More Sources)

Publications:

Benz et al., 1990, Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers., Mol. Pharmacol.
Pohl et al., 1987, Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo., Am. J. Physiol.
Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem
Bauer et al., 2005, Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL., Mol. Cancer Ther.
Li et al., 1985, [The antiandrogen effect of gossypol and its influence on androgen receptor]., Zhongguo Yi Xue Ke Xue Yuan Xue Bao
Van Poznak et al., 2001, Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial., Breast Cancer Res. Treat.
Saksena et al., 1982, Antifertility effects of gossypol in male hamsters., Fertil. Steril.
Hoshiai et al., 1982, Gossypol as oral contraceptive for male: trial case report., Tohoku J. Exp. Med.
Chang et al., 1983, [Comparison of changes of serum gonadotropins and steroid hormones in azoospermic men caused by gossypol and other factors]., Shengzhi Yu Biyun
Jiang et al., The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway., Anticancer Res.

GOSSYPOL BCL2L1

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19555126 16020667

Sources:
DTC
GOSSYPOL PRL

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7075801 6818716 12339175

Sources:
NCI
GOSSYPOL CCND1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11510695

Sources:
NCI
GOSSYPOL TAC1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2887120

Sources:
NCI
GOSSYPOL GALK1

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL HSPA4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2193225

Sources:
NCI
GOSSYPOL TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15015581

Sources:
NCI
GOSSYPOL CASP7

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL ARSA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL PIN1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL CASP1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL USP2

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL BCL2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
GOSSYPOL MCL1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL ALOX15B

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL GAA

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL RGS4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL BLM

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MPHOSPH8

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16020667

Sources:
DTC NCI
GOSSYPOL KAT2A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MTOR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL RECQL

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL APEX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL POLB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL ESR1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL FEN1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL USP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL YES1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL POLI

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL SMAD3

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL POLK

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3158419

Sources:
DTC NCI
GOSSYPOL KDM4E

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL BAZ2B

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL MAPT

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GOSSYPOL CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: GOSSYPOL

Version: 14-September-2017

Alternate Names:

C529 NCI drug code

Drug Info:

Publications:

Van Poznak et al., 2001, Oral gossypol in the treatment of patients with refractory metastatic breast cancer: a phase I/II clinical trial., Breast Cancer Res. Treat.

Benz et al., 1990, Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers., Mol. Pharmacol.

Chang et al., 1983, [Comparison of changes of serum gonadotropins and steroid hormones in azoospermic men caused by gossypol and other factors]., Shengzhi Yu Biyun

DTC: GOSSYPOL
- Version: 02-September-2020
Alternate Names:

CHEMBL51483 ChEMBL Drug ID

Drug Info:

Publications:

Wei J et al., 2009, Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins., J Med Chem
TTD: Gossypol
- Version: 2020.06.01
Alternate Names:

D0Z0HH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL51483
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

GOSSYPOL Drug Record

GOSSYPOL chembl:CHEMBL51483

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19555126 16020667

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7075801 6818716 12339175

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11510695

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2887120

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2193225

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15015581

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
19555126 16020667

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
7075801 6818716 12339175

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11510695

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2887120

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
2193225

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15015581

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
16020667

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found