DGIdb - ISRADIPINE Drug Record

ISRADIPINE chembl:CHEMBL1648 Approved

Alternate Names:

ISRADIPINE
DYNACIRC CR
ISRODIPINE
PN-200-110
DYNACIRC
PRESCAL
ISRADIPINO
ISRADIPINUM
chembl:CHEMBL1648
chemidplus:75695-93-1
pubchem.compound:3784
drugbank:00270
rxcui:33910

Drug Info:

FDA Approval	1990
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1990
Drug Class	vasodilator agents

(3 More Sources)

Publications:

Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Koschak et al., 2001, alpha 1D (Cav1.3) subunits can form l-type Ca2+ channels activating at negative voltages., J. Biol. Chem.
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Berjukow et al., 2000, Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation., J. Biol. Chem.
Zühlke et al., 1998, Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene., FEBS Lett.
Hitzl et al., 2002, A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site., FEBS Lett.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

ISRADIPINE CACNA2D1

Interaction Score: 2.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND
ISRADIPINE CACNA1C

Interaction Score: 1.71

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Trial Name -

PMIDs:
10766758 9607315 12135765

Sources:
TdgClinicalTrial ChemblInteractions TEND
ISRADIPINE CACNA1D

Interaction Score: 1.1

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
11285265 19029287

Sources:
ChemblInteractions
ISRADIPINE CACNA1S

Interaction Score: 0.57

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions
ISRADIPINE CACNA1F

Interaction Score: 0.38

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISRADIPINE NR1I2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ISRADIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TdgClinicalTrial: ISRADIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:
TEND: ISRADIPINE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Drug Class vasodilator agents

Year of Approval 1990

Drug Class antihypertensive agents

Publications:
TTD: Isradipine
- Version: 2020.06.01
Alternate Names:

D0Z7KE TTD Drug ID

Drug Info:

Publications:
DTC: ISRADIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1648 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1648
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1648
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: isradipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Voltage-gated L-type calcium channel blocker
Trial Name	-

Novel drug target	Established target
Trial Name	-

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

ISRADIPINE Drug Record

ISRADIPINE chembl:CHEMBL1648 Approved

Alternate Names:

Drug Info:

Publications:

ISRADIPINE CACNA2D1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284 11752352

Sources: TdgClinicalTrial TEND

ISRADIPINE CACNA1C

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated L-type calcium channel blocker Trial Name -

PMIDs: 10766758 9607315 12135765

Sources: TdgClinicalTrial ChemblInteractions TEND

ISRADIPINE CACNA1D

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 11285265 19029287

Sources: ChemblInteractions

ISRADIPINE CACNA1S

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: 16675661

Sources: ChemblInteractions

ISRADIPINE CACNA1F

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

ISRADIPINE NR1I2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

ISRADIPINE CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TdgClinicalTrial: ISRADIPINE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

TEND: ISRADIPINE

Alternate Names:

Drug Info: Drug Class vasodilator agents Year of Approval 1990 Drug Class antihypertensive agents

Publications:

TTD: Isradipine

Alternate Names: D0Z7KE TTD Drug ID

Drug Info:

Publications:

DTC: ISRADIPINE

Alternate Names: CHEMBL1648 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1648

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1648

Alternate Names:

Drug Info:

Publications:

PharmGKB: isradipine

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Trial Name -

PMIDs:
10766758 9607315 12135765

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
11285265 19029287

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
16675661

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Drug Info:

Drug Class vasodilator agents

Year of Approval 1990

Drug Class antihypertensive agents

Alternate Names:

D0Z7KE TTD Drug ID

Alternate Names:

CHEMBL1648 ChEMBL Drug ID