775 |
CALCIUM VOLTAGE-GATED CHANNEL SUBUNIT ALPHA1 C |
CACNA1C |
CACH2 |
CACN2 |
CACNL1A1 |
CCHL1A1 |
CaV1.2 |
LQT8 |
TS |
114205 |
1390 |
ENSG00000151067 |
OTTHUMG00000150243 |
Voltage-gated calcium channel subunit alpha Cav1.2 |
Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle |
Voltage-dependent L-type calcium channel subunit alpha-1C |
Q13936 |
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936] |
CAC1C_HUMAN |
PA83 |
Voltage-gated calcium channel alpha Cav1.2 |
T51115 |
TS. LQT8 |
Initial Gene Query | Cav1.2 |
Counted Citations from 1950-2000 | 1217 |
Human Readable Name | DRUGGABLE GENOME |
Interpro Short Name | Ion_trans_dom |
Interpro Name | Ion transport domain |
Interpro Type | Domain |
Uniprot Evidence | 1: Evidence at protein level |
Uniprot Status | Swiss-Prot |
Human Readable Name | ION CHANNEL |
Interpro Acc | IPR005821 |
Target Main Class | Transporters |
Target Subclass | CalciumChannels |
Target Subclass | Voltage_gated_ion_channels |
Transmembrane Helix Count | 22 |
Target Subclass | Channels |
Target Class | Transporters |
Target Subclass | TC:1.A.1.11.4 |
Gene Biotype | PROTEIN_CODING |
ION CHANNEL |
DRUGGABLE GENOME |
activator (activating) |
Trial Name | - |
Novel drug target | Established target |
blocker (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Trial Name | - |
blocker (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
Trial Name | Clevelox |
blocker (inhibitory) |
inhibitor (inhibitory) |
Trial Name | enalapril + felodipine,Lexxel |
Novel drug target | Established target |
Trial Name | felodipine ,Plendil |
inhibitor (inhibitory) |
Trial Name | aliskiren + amlodipine,Tekamlo |
Novel drug target | Established target |
Trial Name | amlodipine besylate,Norvasc |
blocker (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
inhibitor (inhibitory) |
Trial Name | - |
Novel drug target | Established target |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
blocker (inhibitory) |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated L-type calcium channel blocker |
Direct Interaction | yes |
modulator |
Mechanism of Interaction | Voltage-gated calcium channel modulator |
Direct Interaction | yes |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated calcium channel modulator |
blocker (inhibitory) |
Mechanism of Interaction | Voltage-gated calcium channel blocker |
Direct Interaction | yes |
modulator |
Direct Interaction | yes |
Mechanism of Interaction | Voltage-gated calcium channel modulator |
modulator |
Mechanism of Interaction | Voltage-gated calcium channel modulator |
Direct Interaction | yes |
modulator |
Mechanism of Interaction | Voltage-gated calcium channel modulator |
Direct Interaction | yes |
CACNA1C | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
775 | Entrez Gene ID |
Initial Gene Query | Cav1.2 |
Counted Citations from 1950-2000 | 1217 |
ION CHANNEL |
CACNA1C | Display Id |
VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL ALPHA-1C SUBUNIT (VOLTAGE- GATED CALCIUM CHANNEL ALPHA SUBUNIT CAV1.2) (CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 1, CARDIAC MUSCLE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13936] | Description |
ENSG00000151067 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
775 | Entrez Gene Id |
Q13936 | Uniprot Accession |
CAC1C_HUMAN | Uniprot Id |
Target Main Class | Transporters |
Target Subclass | CalciumChannels |
Target Subclass | Voltage_gated_ion_channels |
CAC1C_HUMAN | Uniprot Id |
775 | Entrez Gene Id |
CACNA1C | Uniprot Gene Name |
Interpro Short Name | Ion_trans_dom |
Interpro Name | Ion transport domain |
Interpro Type | Domain |
ION CHANNEL, DRUGGABLE GENOME |
CACNA1C | Gene Symbol |
Target Class | Transporters |
Target Subclass | TC:1.A.1.11.4 |
PA83 | PharmGKB ID |
ENSG00000151067 | Gene Symbol |
CACNA1C | Ensembl Id |
DRUGGABLE GENOME |
CACN2 | GENE_SYMBOL |
CACNL1A1 | GENE_SYMBOL |
CCHL1A1 | GENE_SYMBOL |
CACNA1C | TTD Gene Abbreviation |
T51115 | TTD Target ID |
Voltage-dependent L-type calcium channel subunit alpha-1C | Gene Name |
Q13936 | UniProt ID |
ION CHANNEL |