DGIdb - MUPARFOSTAT Drug Record

MUPARFOSTAT chembl:CHEMBL4297163 Antineoplastic

Alternate Names:

MUPARFOSTAT

PI-88

Drug Info:

FDA Approval not approved

Drug Indications antineoplastic agent

Drug Class polysaccharide

(1 More Sources)

Publications:

Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.

MUPARFOSTAT FGF1

Interaction Score: 6.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acidic fibroblast growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
MUPARFOSTAT TFPI

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11292191

Sources:
NCI
MUPARFOSTAT HPSE

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Heparanase inhibitor

Trial Name Muparfostat

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MUPARFOSTAT FGF2

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MUPARFOSTAT VEGFA

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
MUPARFOSTAT FLT4

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
MUPARFOSTAT FGFR2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MUPARFOSTAT FLT1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MUPARFOSTAT FGFR1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
MUPARFOSTAT KDR

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

TdgClinicalTrial: PI-88
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class polysaccharide

Drug Indications antineoplastic agent

FDA Approval not approved

Publications:
NCI: PI-88
- Version: 14-September-2017
Alternate Names:

C38690 NCI drug code

Drug Info:

Publications:

Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.
TTD: PI-88
- Version: 2020.06.01
Alternate Names:

D04ZJG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL4297163
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1615835
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

FDA Approval	not approved
Drug Indications	antineoplastic agent
Drug Class	polysaccharide

Mechanism of Interaction	Acidic fibroblast growth factor inhibitor
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Heparanase inhibitor
Trial Name	Muparfostat

Direct Interaction	yes
Mechanism of Interaction	Basic fibroblast growth factor inhibitor

Direct Interaction	yes
Mechanism of Interaction	Vascular endothelial growth factor A inhibitor

MUPARFOSTAT
PI-88

Trial Name	Muparfostat
Novel drug target	Established target

Trial Name	Muparfostat
Novel drug target	Established target

Trial Name	Muparfostat
Novel drug target	Established target

MUPARFOSTAT Drug Record

MUPARFOSTAT chembl:CHEMBL4297163 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Acidic fibroblast growth factor inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11292191

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Heparanase inhibitor Trial Name Muparfostat

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor A inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Muparfostat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Muparfostat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Muparfostat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Muparfostat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Muparfostat Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

TdgClinicalTrial: PI-88

Alternate Names:

Drug Info: Drug Class polysaccharide Drug Indications antineoplastic agent FDA Approval not approved

Publications:

NCI: PI-88

Alternate Names: C38690 NCI drug code

Drug Info:

Publications: Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.

TTD: PI-88

Alternate Names: D04ZJG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL4297163

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1615835

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Acidic fibroblast growth factor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11292191

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Heparanase inhibitor

Trial Name Muparfostat

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Basic fibroblast growth factor inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor A inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Muparfostat

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Drug Info:

Drug Class polysaccharide

Drug Indications antineoplastic agent

FDA Approval not approved

Alternate Names:

C38690 NCI drug code

Publications:

Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.

Alternate Names:

D04ZJG TTD Drug ID