DGIdb - PAPAVERINE Drug Record

PAPAVERINE chembl:CHEMBL19224 Approved

Alternate Names:

PAPAVERINE
NSC-136630
MESOTINA
rxcui:7895
chembl:CHEMBL19224
pubchem.compound:4680
drugbank:01113
chemidplus:58-74-2

Drug Info:

Drug Class	antispasmodics
Drug Class	anti-impotence agents
Year of Approval	not approved by the fda
Drug Class	vasodilator agents
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Anti-impotence Agents
Drug Indications	Antispasmodics

(2 More Sources)

Publications:

Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.
Xin et al., 2003, Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities., Asian J. Androl.
Zhu et al., 2009, The measurement of cyclic nucleotide phosphodiesterase 4 activities via the quantification of inorganic phosphate with malachite green., Anal. Chim. Acta
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Kishko et al., [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]., Ukr Biokhim Zh (1999)
Armstead et al., 2005, Plasminogen activators contribute to age-dependent impairment of NMDA cerebrovasodilation after brain injury., Brain Res. Dev. Brain Res.

PAPAVERINE PDE4B

Interaction Score: 0.77

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12646997 19231363 17016423 17139284

Sources:
TdgClinicalTrial TEND
PAPAVERINE XDH

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11200484

Sources:
NCI
PAPAVERINE PLAU

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16099300

Sources:
NCI
PAPAVERINE ADRA1D

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9351495

Sources:
NCI
PAPAVERINE PDE5A

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PAPAVERINE CREBBP

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE PDE4D

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PAPAVERINE THPO

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PAPAVERINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PAPAVERINE
- Version: 01-August-2011
Alternate Names:

PAPAVERINE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval not approved by the fda

Drug Class anti-impotence agents

Publications:
TdgClinicalTrial: PAPAVERINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antispasmodics

Drug Indications Anti-impotence Agents

Drug Indications Vasodilator Agents

Publications:

NCI: PAPAVERINE

Version: 14-September-2017

Alternate Names:

C726 NCI drug code

Drug Info:

Publications:

Chulia et al., 1997, Relationships between structure and vascular activity in a series of benzylisoquinolines., Br. J. Pharmacol.

Kishko et al., [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]., Ukr Biokhim Zh (1999)

Armstead et al., 2005, Plasminogen activators contribute to age-dependent impairment of NMDA cerebrovasodilation after brain injury., Brain Res. Dev. Brain Res.

TTD: Papaverine
- Version: 2020.06.01
Alternate Names:

D0NJ3V TTD Drug ID

Drug Info:

Publications:
DTC: PAPAVERINE
- Version: 02-September-2020
Alternate Names:

CHEMBL19224 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL19224
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

PAPAVERINE Drug Record

PAPAVERINE chembl:CHEMBL19224 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 12646997 19231363 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11200484

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16099300

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9351495

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: PAPAVERINE

Alternate Names: PAPAVERINE Primary Drug Name

Drug Info: Drug Class vasodilator agents Year of Approval not approved by the fda Drug Class anti-impotence agents

Publications:

TdgClinicalTrial: PAPAVERINE

Alternate Names:

Drug Info: Drug Indications Antispasmodics Drug Indications Anti-impotence Agents Drug Indications Vasodilator Agents

Publications:

NCI: PAPAVERINE

Alternate Names: C726 NCI drug code

Drug Info:

TTD: Papaverine

Alternate Names: D0NJ3V TTD Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
12646997 19231363 17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
11200484

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16099300

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9351495

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

PAPAVERINE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval not approved by the fda

Drug Class anti-impotence agents

Drug Info:

Drug Indications Antispasmodics

Drug Indications Anti-impotence Agents

Drug Indications Vasodilator Agents

Alternate Names:

C726 NCI drug code

Alternate Names:

D0NJ3V TTD Drug ID

Alternate Names:

CHEMBL19224 ChEMBL Drug ID