DGIdb - PIMOZIDE Drug Record

PIMOZIDE chembl:CHEMBL1423 Approved

Alternate Names:

MCN-JR-6238
R-623
PIMOZIDE
NSC-170984
R-6238
ORAP
R 623
HALDOL DECANOATE
PIMOZIDUM
ORAP®
PIMOZIDA
chemidplus:2062-78-4
chembl:CHEMBL1423
drugbank:01100
pubchem.compound:16362
rxcui:8331

Drug Info:

FDA Approval	1984
Drug Class	small molecule
Drug Indications	Antipsychotic Agents
Drug Indications	Antidyskinetics
Year of Approval	1984
Drug Class	antidyskinetics
Drug Class	antipsychotic agents

(4 More Sources)

Publications:

Freedman et al., 1994, Expression and pharmacological characterization of the human D3 dopamine receptor., J. Pharmacol. Exp. Ther.
Osypenko et al., 2001, [Blockade of HERG K+ channels expressed in Xenopus oocytes by antipsychotic agents]., Fiziol Zh
Kang et al., 2001, The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel., Biochem. Biophys. Res. Commun.
Kang et al., 2000, High affinity blockade of the HERG cardiac K(+) channel by the neuroleptic pimozide., Eur. J. Pharmacol.
Shuba et al., 2001, Testosterone-mediated modulation of HERG blockade by proarrhythmic agents., Biochem. Pharmacol.
Cusack et al., 1994, Binding of antidepressants to human brain receptors: focus on newer generation compounds., Psychopharmacology (Berl.)
Murphy et al., 1999, Inhibition of luteinizing hormone secretion by delta9-tetrahydrocannabinol in the ovariectomized rat: effect of pretreatment with neurotransmitter or neuropeptide receptor antagonists., Steroids
Zarrindast et al., 1994, On the mechanisms by which theophylline changes core body temperature in mice., Eur. J. Pharmacol.
Muscat et al., 1990, Dopaminergic mechanism of imipramine action in an animal model of depression., Biol. Psychiatry
Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Silva et al., 2003, Pimozide injections into the Nucleus accumbens disrupt maternal behaviour in lactating rats., Pharmacol. Toxicol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther
Rogers HL et al., 2012, CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration's new dosing recommendations., J Clin Psychiatry

PIMOZIDE DRD5

Interaction Score: 0.18

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE DRD2

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
7855217 10503726 8301582 8082693 2378927 11873706 12828573 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PIMOZIDE XBP1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE DRD3

Interaction Score: 0.07

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
8301582

Sources:
ChemblInteractions
PIMOZIDE DRD4

Interaction Score: 0.06

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE KCNH2

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
11296551 11511086 10762666 11377395

Sources:
DTC
PIMOZIDE RXRA

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE THPO

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE NPSR1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE HTR2A

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9951426 23059146

Sources:
DTC PharmGKB FDA
PIMOZIDE MPHOSPH8

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE MTOR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE PPARD

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE HIF1A

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE DRD1

Interaction Score: 0.02

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PIMOZIDE MAPK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE ATXN2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE ATAD5

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE TP53

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE IDH1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PIMOZIDE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: PIMOZIDE
- Version: 01-August-2011
Alternate Names:

PIMOZIDE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Drug Class antidyskinetics

Year of Approval 1984

Publications:
TdgClinicalTrial: PIMOZIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antidyskinetics

Drug Indications Antipsychotic Agents

Drug Class small molecule

Publications:

PharmGKB: pimozide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Desta Z et al., 1999, Effect of clarithromycin on the pharmacokinetics and pharmacodynamics of pimozide in healthy poor and extensive metabolizers of cytochrome P450 2D6 (CYP2D6)., Clin Pharmacol Ther

Rogers HL et al., 2012, CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration's new dosing recommendations., J Clin Psychiatry

DTC: PIMOZIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL1423 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Pimozide
- Version: 2020.06.01
Alternate Names:

D00KHM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1423
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Pimozide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1423
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Dopamine receptor antagonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Serotonin 2a (5-HT2a) receptor antagonist

PIMOZIDE Drug Record

PIMOZIDE chembl:CHEMBL1423 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes Novel drug target Established target

PMIDs: 7855217 10503726 8301582 8082693 2378927 11873706 12828573 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: 8301582

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 11296551 11511086 10762666 11377395

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9951426 23059146

Sources: DTC PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Dopamine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
7855217 10503726 8301582 8082693 2378927 11873706 12828573 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
8301582

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
11296551 11511086 10762666 11377395

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serotonin 2a (5-HT2a) receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9951426 23059146

Sources:
DTC PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Dopamine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found