DGIdb - ADORA2B Gene Record

ADORA2B 136 Druggable Genome

Alternate Names:

136
ADENOSINE A2B RECEPTOR
ADORA2B
ADORA2
600446
264
ENSG00000170425
OTTHUMG00000059140
ADENOSINE RECEPTOR A2B
P29275
AA2BR_HUMAN
ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275]
P29274
ADORA2A
T86679

Gene Info:

Target Subclass	Rhodopsin
Target Subclass	GPCR
Target Main Class	Receptors
Transmembrane Helix Count	7
Human Readable Name	G PROTEIN COUPLED RECEPTOR
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Short Name	7TM_GPCR_Rhodpsn
Interpro Type	Family
Interpro Acc	IPR000276
Uniprot Evidence	2: Evidence at transcript level
Interpro Name	GPCR, rhodopsin-like, 7TM
Target Class	Receptors
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

G PROTEIN COUPLED RECEPTOR
DRUGGABLE GENOME

Publications:

Phelps et al., 2006, Characterization of adenosine receptors in the human bladder carcinoma T24 cell line., Eur. J. Pharmacol.
Philipp et al., 2006, Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade., Cardiovasc. Res.
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Holgate, 2005, The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fozard et al., 2003, Antagonist pharmacology of adenosine A2B receptors from rat, guinea pig and dog., Eur. J. Pharmacol.
Funakoshi et al., 2007, A1 adenosine receptor upregulation accompanies decreasing myocardial adenosine levels in mice with left ventricular dysfunction., Circulation
Kreckler et al., 2006, Adenosine inhibits tumor necrosis factor-alpha release from mouse peritoneal macrophages via A2A and A2B but not the A3 adenosine receptor., J. Pharmacol. Exp. Ther.
Schenone et al., 2010, A1 receptors ligands: past, present and future trends., Curr Top Med Chem
Buenestado et al., 2010, The role of adenosine receptors in regulating production of tumour necrosis factor-alpha and chemokines by human lung macrophages., Br. J. Pharmacol.
Ezeamuzie et al., 2007, The role of adenosine A(2) receptors in the regulation of TNF-alpha production and PGE(2) release in mouse peritoneal macrophages., Int. Immunopharmacol.
Haschemi et al., 2007, Cross-regulation of carbon monoxide and the adenosine A2a receptor in macrophages., J. Immunol.
Trincavelli et al., 2010, Adenosine receptors: what we know and what we are learning., Curr Top Med Chem
Ribeiro et al., 2010, Caffeine and adenosine., J. Alzheimers Dis.

LAS101057 ADORA2B

Interaction Score: 5.62

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2b receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD
ADENOSINE ADORA2B

Interaction Score: 3.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine receptor agonist

Direct Interaction yes

PMIDs:
17438146 16339914 20370661 20136829 17321471 17442976 20370662

Sources:
ChemblInteractions TTD
XANTHINE ADORA2B

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BVT.115959 ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BVT.115959

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
TOZADENANT ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SYN-115

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
QAF805 ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2b receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AB-928 ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BINODENOSON ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name binodenoson, MRE 0470,CorVue

PMIDs:
None found

Sources:
TdgClinicalTrial
VIDARABINE ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PRELADENANT ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name preladenant, SCH-420814

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ISTRADEFYLLINE ADORA2B

Interaction Score: 1.41

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name istradefylline, KW-6002

PMIDs:
None found

Sources:
TdgClinicalTrial
GS 6201 ADORA2B

Interaction Score: 1.2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2b receptor antagonist

Trial Name CVT-6883

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
THEOPHYLLINE ADORA2B

Interaction Score: 1.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16581066 16545350 3588607 15980878 11752352 12954362

Sources:
TdgClinicalTrial ChemblInteractions TEND
CHEMBL27508 ADORA2B

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
REGADENOSON ADORA2B

Interaction Score: 0.94

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name regadenoson,Lexiscan

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
CAFFEINE, CITRATED ADORA2B

Interaction Score: 0.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TONAPOFYLLINE ADORA2B

Interaction Score: 0.7

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
TTD
CAFFEINE ADORA2B

Interaction Score: 0.31

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
20164566

Sources:
TdgClinicalTrial ChemblInteractions
THEOPHYLLINE SODIUM GLYCINATE ADORA2B

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA2B

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA2B

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE ADORA2B

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2 receptor antagonist

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Ensembl: ENSG00000170425
- Version: 101_38
Alternate Names:

ADORA2B Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P29275
- Version: 01-August-2011
Alternate Names:

ADORA2B Gene Symbol

AA2BR_HUMAN Uniprot Id

P29275 Uniprot Accession

Gene Info:

Target Subclass Rhodopsin

Target Subclass GPCR

Target Main Class Receptors

Publications:
RussLampel: ENSG00000170425
- Version: 26-July-2011
Alternate Names:

ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275] Description

ENSG00000170425 Ensembl Gene Id

ADORA2B Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
HopkinsGroom: P29275
- Version: 11-September-2012
Alternate Names:

ENSG00000170425 Ensembl Gene Id

ADENOSINE RECEPTOR A2B Uniprot Protein Name

136 Entrez Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Uniprot Status Swiss-Prot

Interpro Short Name 7TM_GPCR_Rhodpsn

Gene Categories:

G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P29275
- Version: January-2014
Alternate Names:

ADORA2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
TdgClinicalTrial: P29274
- Version: January-2014
Alternate Names:

ADORA2A Gene Symbol

ADORA2B Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass GPCR

Target Subclass Rhodopsin

Publications:
HingoraniCasas: ENSG00000170425
- Version: 31-May-2017
Alternate Names:

ENSG00000170425 Gene Symbol

ADORA2B Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: ADORA2B
- Version: chembl_23
Alternate Names:

ADORA2B GENE_SYMBOL

Adenosine receptor A2b UNIPROT

Gene Info:

Publications:
dGene: ADORA2B
- Version: 27-Jun-2013
Alternate Names:

136 Gene ID

ADORA2 dGene Synonym

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:
TTD: Adenosine A2b receptor
- Version: 2020.06.01
Alternate Names:

ADORA2B TTD Gene Abbreviation

T86679 TTD Target ID

Gene Info:

Publications:
GO: ADORA2B
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

G PROTEIN COUPLED RECEPTOR

Publications:

Direct Interaction	yes
Mechanism of Interaction	Adenosine A2b receptor antagonist

Mechanism of Interaction	Adenosine receptor agonist
Direct Interaction	yes

Novel drug target	Established target
Trial Name	binodenoson, MRE 0470,CorVue

Trial Name	preladenant, SCH-420814
Novel drug target	Established target

Trial Name	ADC4022, low-dose inhaled theophylline
Novel drug target	Established target
Mechanism of Interaction	Adenosine receptor antagonist

Trial Name	regadenoson,Lexiscan
Novel drug target	Established target

Direct Interaction	yes
Mechanism of Interaction	Adenosine A2 receptor antagonist
Novel drug target	Established target

ADORA2B	Gene Symbol
AA2BR_HUMAN	Uniprot Id
P29275	Uniprot Accession

ADENOSINE A2B RECEPTOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P29275]	Description
ENSG00000170425	Ensembl Gene Id
ADORA2B	Display Id

ADORA2B Gene Record

ADORA2B 136 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2b receptor antagonist

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Adenosine receptor agonist Direct Interaction yes

PMIDs: 17438146 16339914 20370661 20136829 17321471 17442976 20370662

Sources: ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name BVT.115959 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name SYN-115 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine A2b receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Novel drug target Established target Trial Name binodenoson, MRE 0470,CorVue

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name preladenant, SCH-420814 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Novel drug target Established target Trial Name istradefylline, KW-6002

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine A2b receptor antagonist Trial Name CVT-6883

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name ADC4022, low-dose inhaled theophylline Novel drug target Established target Mechanism of Interaction Adenosine receptor antagonist

PMIDs: 16581066 16545350 3588607 15980878 11752352 12954362

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name regadenoson,Lexiscan Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes Trial Name -

PMIDs: 20164566

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2b receptor antagonist

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Adenosine receptor agonist

Direct Interaction yes

PMIDs:
17438146 16339914 20370661 20136829 17321471 17442976 20370662

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name BVT.115959

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name SYN-115

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2b receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Novel drug target Established target

Trial Name binodenoson, MRE 0470,CorVue

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name preladenant, SCH-420814

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name istradefylline, KW-6002

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2b receptor antagonist

Trial Name CVT-6883

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name ADC4022, low-dose inhaled theophylline

Novel drug target Established target

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16581066 16545350 3588607 15980878 11752352 12954362

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name regadenoson,Lexiscan

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

Trial Name -

PMIDs:
20164566

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)