DGIdb - PENTOXIFYLLINE Drug Record

PENTOXIFYLLINE chembl:CHEMBL628 Approved

Alternate Names:

PENTOXIL
TRENTAL
OXPENTIFYLLINE
C04AD03
BL-191
PENTOXIFYLLINE
NEOTREN MR
TRENTAL 100
NSC-637086
TRENTAL 400
PENTOXIFILINA
PENTOXIFYLLIN
TRENTAL®
PENTOXIFYLLINUM
chemidplus:6493-05-6
pubchem.compound:4740
drugbank:00806
rxcui:8013
chembl:CHEMBL628

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of amyotrophic lateral sclerosis (ALS)
Year of Approval	1984
Drug Class	hemorrheologic agents
Drug Class	platelet aggregation inhibitors

(2 More Sources)

Publications:

Osterreicher et al., 2001, Apoptosis and bcl-2 expression in irradiated lungs and the effect of pentoxifylline., Acta Medica (Hradec Kralove)
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Jean Harry et al., 2003, Differential modulation of hippocampal chemical-induced injury response by ebselen, pentoxifylline, and TNFalpha-, IL-1alpha-, and IL-6-neutralizing antibodies., J. Neurosci. Res.
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tranquille et al., 1991, The effect of pentoxifylline (Trental) and two analogues, BL 194 and HWA 448, on the release of plasminogen activators and von Willebrand factor in rats., J. Cardiovasc. Pharmacol.
Hadjiminas et al., 1994, Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis., Surgery
Sakamaki et al., 1999, Effects of lung preservation solutions on PMN activation in vitro., Transpl. Int.
Kreth et al., 2010, Immunomodulatory properties of pentoxifylline are mediated via adenosine-dependent pathways., Shock
Moser et al., 2000, Effect of preoperative interventions on outcome following liver resection in a rat model of cirrhosis., J. Hepatol.
Chen et al., 2003, Up-regulation of tumor interleukin-8 expression by infiltrating macrophages: its correlation with tumor angiogenesis and patient survival in non-small cell lung cancer., Clin. Cancer Res.

PENTOXIFYLLINE PCNA

Interaction Score: 1.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10707869

Sources:
NCI
PENTOXIFYLLINE PDE1B

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE1C

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6B

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE1A

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6H

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6C

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6G

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6D

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE6A

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE9A

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE8A

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE2A

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE8B

Interaction Score: 0.61

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE7B

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE5A

Interaction Score: 0.38

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

Trial Name pentoxifylline, EHT0201

PMIDs:
11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND
PENTOXIFYLLINE PDE7A

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE10A

Interaction Score: 0.36

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE4B

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND
PENTOXIFYLLINE VWF

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1719289

Sources:
NCI
PENTOXIFYLLINE PDE3B

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE PDE4A

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND
PENTOXIFYLLINE ITGB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10363593

Sources:
NCI
PENTOXIFYLLINE ADORA2B

Interaction Score: 0.17

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine A2 receptor antagonist

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
PENTOXIFYLLINE GFAP

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12898537

Sources:
NCI
PENTOXIFYLLINE PDE4C

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE ADORA1

Interaction Score: 0.12

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

PMIDs:
3588607

Sources:
TdgClinicalTrial
PENTOXIFYLLINE ADORA2A

Interaction Score: 0.11

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine A2 receptor antagonist

Direct Interaction yes

PMIDs:
19997047

Sources:
ChemblInteractions
PENTOXIFYLLINE IL1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8048000

Sources:
NCI
PENTOXIFYLLINE PDE3A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE BCL2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11836847

Sources:
NCI
PENTOXIFYLLINE CXCL8

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12576442

Sources:
NCI
PENTOXIFYLLINE PDE4D

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PENTOXIFYLLINE TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

TEND: PENTOXIFYLLINE
- Version: 01-August-2011
Alternate Names:

PENTOXIFYLLINE Primary Drug Name

Drug Info:

Drug Class platelet aggregation inhibitors

Drug Class hemorrheologic agents

Year of Approval 1984

Publications:
TdgClinicalTrial: PENTOXIFYLLINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of amyotrophic lateral sclerosis (ALS)

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: PENTOXIFYLLINE

Version: 14-September-2017

Alternate Names:

C733 NCI drug code

Drug Info:

Publications:

Hadjiminas et al., 1994, Enhanced survival from cecal ligation and puncture with pentoxifylline is associated with altered neutrophil trafficking and reduced interleukin-1 beta expression but not inhibition of tumor necrosis factor synthesis., Surgery

Moser et al., 2000, Effect of preoperative interventions on outcome following liver resection in a rat model of cirrhosis., J. Hepatol.

Tranquille et al., 1991, The effect of pentoxifylline (Trental) and two analogues, BL 194 and HWA 448, on the release of plasminogen activators and von Willebrand factor in rats., J. Cardiovasc. Pharmacol.

TTD: Pentoxifylline
- Version: 2020.06.01
Alternate Names:

D09QEI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL628
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL628
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor
Direct Interaction	yes

Trial Name	pentoxifylline, EHT0201
Novel drug target	Established target
Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction	yes
Mechanism of Interaction	Adenosine A2 receptor antagonist
Novel drug target	Established target

PENTOXIFYLLINE Drug Record

PENTOXIFYLLINE chembl:CHEMBL628 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10707869

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes Trial Name pentoxifylline, EHT0201

PMIDs: 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name pentoxifylline, EHT0201 Novel drug target Established target Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: 17016423 17139284

Interaction Types & Directionality:

n/a

PMIDs:
10707869

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

Trial Name pentoxifylline, EHT0201

PMIDs:
11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name pentoxifylline, EHT0201

Novel drug target Established target

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
1719289

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes