DGIdb - OXTRIPHYLLINE Drug Record

OXTRIPHYLLINE chembl:CHEMBL1200434 Approved

Alternate Names:

CHOLINE THEOPHYLLINATE
OXTRIPHYLLINE PEDIATRIC
SABIDAL
OXTRIPHYLLINE
CHOLEDYL
CHOLINE THEOPHYLLINE
CHOLEDYL SA
THEOPHYLINE - CHOLINE MIXT
THEOCOLIN
chemidplus:4499-40-5
drugbank:01303
pubchem.compound:656652
rxcui:20976
chembl:CHEMBL1200434

Drug Info:

(0 More Sources)

Publications:

Pechlivanova et al., 2005, Effects of single and long-term theophylline treatment on the threshold of mechanical nociception: contribution of adenosine A1 and alpha2-adrenoceptors., Methods Find Exp Clin Pharmacol
Daly et al., 1987, Adenosine receptors: development of selective agonists and antagonists., Prog. Clin. Biol. Res.
Kajikawa et al., 2006, Changes in submaxillary gland gene expression in F344 rats by multiple dosing of theophylline., Exp. Anim.
Wu et al., 2004, KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels., Br. J. Pharmacol.
Rickards et al., 2003, Differential effects of phosphodiesterase inhibitors on platelet activating factor (PAF)- and adenosine diphosphate (ADP)-induced equine platelet aggregation., J. Vet. Pharmacol. Ther.
Nantwi et al., 2003, Adenosine A1 receptor mRNA expression and the effects of systemic theophylline administration on respiratory function 4 months after C2 hemisection., J Spinal Cord Med
Usta et al., 2004, The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations., Prostaglandins Leukot. Essent. Fatty Acids
Haider, 2003, Cyclic AMP level and phosphodiesterase activity during 17alpha,20beta-dihydroxy-4-pregnen-3-one induction and theophylline inhibition of oocyte maturation in the catfish, Clarias batrachus., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
Wang et al., 2002, Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45., Acta Pharmacol. Sin.
Lee et al., 2004, Modulation of thyroidal radioiodine uptake by theophylline., Exp. Mol. Pathol.

OXTRIPHYLLINE PDE3A

Interaction Score: 1.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
16651698 15237094 12887610

Sources:
ChemblInteractions TTD
OXTRIPHYLLINE PDE4A

Interaction Score: 1.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
15253881 12547256 12421478 15351234 12887610

Sources:
ChemblInteractions TTD
OXTRIPHYLLINE PDE3B

Interaction Score: 0.88

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA1

Interaction Score: 0.6

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
3588607 14992338

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA2A

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16357952 3588607

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4C

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA3

Interaction Score: 0.33

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE ADORA2B

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
OXTRIPHYLLINE PDE4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TTD: Oxtriphylline
- Version: 2020.06.01
Alternate Names:

D0B0SH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1200434
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1200434
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 3 inhibitor

Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Direct Interaction	yes

Mechanism of Interaction	Adenosine receptor antagonist
Direct Interaction	yes

OXTRIPHYLLINE Drug Record

OXTRIPHYLLINE chembl:CHEMBL1200434 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs: 16651698 15237094 12887610

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: 15253881 12547256 12421478 15351234 12887610

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 3 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 3588607 14992338

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Adenosine receptor antagonist

PMIDs: 16357952 3588607

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TTD: Oxtriphylline

Alternate Names: D0B0SH TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1200434

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1200434

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
16651698 15237094 12887610

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
15253881 12547256 12421478 15351234 12887610

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 3 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
3588607 14992338

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Adenosine receptor antagonist

PMIDs:
16357952 3588607

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

D0B0SH TTD Drug ID