DGIdb - AMINOPHYLLINE Drug Record

AMINOPHYLLINE chembl:CHEMBL1370561 Approved

Alternate Names:

AMNIVENT-225 SR
PETERPHYLLIN
SOMOPHYLLIN
THEOPHYLLINE ETHYLENEDIAMINE
AMMOPHYLLIN
THEOPHYLLAMINE
PHYLLOCONTIN
AMINOPHYLLINE IN SODIUM CHLORIDE
SOMOPHYLLIN-DF
AMINOPHYLLIN
NSC-7919
AMINOPHYLLINE
TRUPHYLLINE
AMINOPHYLLINE DYE FREE
AMNIVENT-350 SR
AMINOPHILLINE
rxcui:689
chembl:CHEMBL1370561
drugbank:01223
chemidplus:317-34-0
pubchem.compound:9433

Drug Info:

(0 More Sources)

Publications:

Lerman, 1993, Response of nonreentrant catecholamine-mediated ventricular tachycardia to endogenous adenosine and acetylcholine. Evidence for myocardial receptor-mediated effects., Circulation
Yamamoto et al., 2003, Intrathecal adenosine A1 receptor agonist attenuates hyperalgesia without inhibiting spinal glutamate release in the rat., Cell. Mol. Neurobiol.
Hirota et al., 2002, Spasmolytic effects of colforsin daropate on serotonin-induced pulmonary hypertension and bronchoconstriction in dogs., Acta Anaesthesiol Scand
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Stella et al., 1998, The role of A3 adenosine receptors in central regulation of arterial blood pressure., Br. J. Pharmacol.

AMINOPHYLLINE PDE3A

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
11939921 11752352

Sources:
ChemblInteractions TTD
AMINOPHYLLINE PDE3B

Interaction Score: 0.88

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA3

Interaction Score: 0.65

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
9806324

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA1

Interaction Score: 0.6

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
8425287 12735630

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4C

Interaction Score: 0.44

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA2B

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4D

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4A

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE ADORA2A

Interaction Score: 0.19

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
AMINOPHYLLINE PDE4B

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

TTD: Aminophylline
- Version: 2020.06.01
Alternate Names:

D03TYI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1370561
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1370561
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Phosphodiesterase 3 inhibitor

Mechanism of Interaction	Adenosine receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Phosphodiesterase 4 inhibitor
Direct Interaction	yes

AMINOPHYLLINE Drug Record

AMINOPHYLLINE chembl:CHEMBL1370561 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs: 11939921 11752352

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 9806324

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: 8425287 12735630

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Adenosine receptor antagonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Phosphodiesterase 4 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

TTD: Aminophylline

Alternate Names: D03TYI TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1370561

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1370561

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
11939921 11752352

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Phosphodiesterase 3 inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
9806324

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
8425287 12735630

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Adenosine receptor antagonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Phosphodiesterase 4 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

D03TYI TTD Drug ID