DGIdb - PREGABALIN Drug Record

PREGABALIN chembl:CHEMBL1059 Approved

Alternate Names:

YNP-1807
ALZAIN
REWISCA
CI-1008
PD-144723
LYRICA
LYRICA CR
LECAENT
AXALID
PREGABALIN
LYRICA®
(S)-PREGABALIN
(S)-3-ISOBUTYL GABA
(S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID
NERVALIN®
3-ISOBUTYL GABA
PD 144723
S-(+)-3-ISOBUTYLGABA
CI 1008
chembl:CHEMBL1059
drugbank:00230
chemidplus:148553-50-8
pubchem.compound:5486971
rxcui:187832

Drug Info:

Drug Class	anticonvulsants
Year of Approval	2004
Drug Class	analgesics
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic,neuropathic pain,for treatment of restlegs legs syndrome

(1 More Sources)

Publications:

Gazulla et al., 2007, The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit., Med. Hypotheses
Jacquy et al., [Pregabalin (Lyrica) and neuropathic pain syndromes]., Rev Med Brux
Gazulla et al., 2007, The P/Q-type voltage-dependent calcium channel: a therapeutic target in spinocerebellar ataxia type 6., Acta Neurol. Scand.
Taylor et al., 2007, Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery., Epilepsy Res.
Field et al., 2006, Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin., Proc. Natl. Acad. Sci. U.S.A.
Verma V et al., 2014, Pregabalin in neuropathic pain: evidences and possible mechanisms., Curr Neuropharmacol

PREGABALIN CACNA1A

Interaction Score: 1.8

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name pregabalin,Lyrica

PMIDs:
16899342 17144644 17489948 17126531 17088553

Sources:
TdgClinicalTrial ChemblInteractions TEND
PREGABALIN CACNG4

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA2D1

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
24533015

Sources:
ChemblInteractions TTD
PREGABALIN CACNG5

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNG6

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNG7

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNG3

Interaction Score: 0.41

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA2D4

Interaction Score: 0.35

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA2D3

Interaction Score: 0.35

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNG2

Interaction Score: 0.35

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1E

Interaction Score: 0.31

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNB1

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNB3

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNB4

Interaction Score: 0.27

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNB2

Interaction Score: 0.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA2D2

Interaction Score: 0.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNG1

Interaction Score: 0.19

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1I

Interaction Score: 0.15

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1G

Interaction Score: 0.15

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1F

Interaction Score: 0.11

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1D

Interaction Score: 0.1

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1H

Interaction Score: 0.09

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1B

Interaction Score: 0.09

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1S

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
PREGABALIN CACNA1C

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

TEND: PREGABALIN
- Version: 01-August-2011
Alternate Names:

PREGABALIN Primary Drug Name

Drug Info:

Drug Class analgesics

Year of Approval 2004

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: PREGABALIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic,neuropathic pain,for treatment of restlegs legs syndrome

Drug Class Small Molecule

FDA Approval approved

Publications:
TTD: Pregabalin
- Version: 2020.06.01
Alternate Names:

D00WUF TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1059
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1059
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Voltage-gated calcium channel modulator
Direct Interaction	yes
Trial Name	pregabalin,Lyrica

inhibitor (inhibitory)
modulator

PREGABALIN Drug Record

PREGABALIN chembl:CHEMBL1059 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes Trial Name pregabalin,Lyrica

PMIDs: 16899342 17144644 17489948 17126531 17088553

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: 24533015

Sources: ChemblInteractions TTD

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name pregabalin,Lyrica

PMIDs:
16899342 17144644 17489948 17126531 17088553

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
24533015

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions