DGIdb - GABAPENTIN Drug Record

GABAPENTIN chembl:CHEMBL940 Approved

Alternate Names:

GOE-3450
NEURONTIN
DM-1796
GABAPENTIN
GRALISE
CI-945
NEURONTIN®
ACLONIUM
GABAPENTINO
GABAPENTINUM
NOVO-GABAPENTINE
2-[1-(AMINOMETHYL)CYCLOHEXYL]ACETIC ACID
GABAPENTIN GR
GO 3450
GOE 3450
GABAPENTINE
GOE 2450
1-(AMINOMETHYL)CYCLOHEXANEACETIC ACID
GABAPENTINA
GABAPETIN
CI 945
chembl:CHEMBL940
chemidplus:60142-96-3
drugbank:00996
pubchem.compound:3446
rxcui:25480

Drug Info:

Drug Indications	analgesic
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of neuropathic pain
Drug Class	anticonvulsants
Year of Approval	1993
Drug Class	analgesics

(2 More Sources)

Publications:

Hota et al., 2007, Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study., Methods Find Exp Clin Pharmacol
Hoffmann et al., 2010, Gabapentin suppresses cortical spreading depression susceptibility., J. Cereb. Blood Flow Metab.
Hendrich et al., 2008, Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin., Proc. Natl. Acad. Sci. U.S.A.
Maneuf et al., 2006, alpha2delta and the mechanism of action of gabapentin in the treatment of pain., Semin. Cell Dev. Biol.
Gazulla et al., 2007, The P/Q-type voltage-dependent calcium channel as pharmacological target in spinocerebellar ataxia type 6: gabapentin and pregabalin may be of therapeutic benefit., Med. Hypotheses
Kukkar A et al., 2013, Implications and mechanism of action of gabapentin in neuropathic pain., Arch Pharm Res
Cheng et al., 2006, The antiallodynic action target of intrathecal gabapentin: Ca2+ channels, KATP channels or N-methyl-d-aspartic acid receptors?, Anesth. Analg.
Kang et al., 2007, The effect of MDR1 G2677T/A polymorphism on pharmacokinetics of gabapentin in healthy Korean subjects., Arch. Pharm. Res.
Baydas et al., 2005, Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats., Acta Pharmacol. Sin.
Oka et al., 2003, Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex., Pharm. Res.

GABAPENTIN CACNA2D2

Interaction Score: 1.77

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name Depomed

PMIDs:
17982508 18299583 20588320 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND
GABAPENTIN CACNA2D1

Interaction Score: 1.1

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Trial Name Depomed

Novel drug target Established target

Trial Name gabapentin,N/

PMIDs:
17982508 20588320 18299583 17067834 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND
GABAPENTIN ENO2

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15780189

Sources:
NCI
GABAPENTIN CACNA1B

Interaction Score: 0.47

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

Trial Name Depomed

PMIDs:
16368827 18299583 20588320

Sources:
TdgClinicalTrial ChemblInteractions TEND
GABAPENTIN CACNG7

Interaction Score: 0.37

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG5

Interaction Score: 0.37

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG4

Interaction Score: 0.37

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG3

Interaction Score: 0.37

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG6

Interaction Score: 0.37

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA2D3

Interaction Score: 0.32

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG2

Interaction Score: 0.32

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA2D4

Interaction Score: 0.32

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1E

Interaction Score: 0.28

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNB3

Interaction Score: 0.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNB4

Interaction Score: 0.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNB1

Interaction Score: 0.25

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNB2

Interaction Score: 0.22

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1A

Interaction Score: 0.2

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNG1

Interaction Score: 0.17

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1I

Interaction Score: 0.14

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1G

Interaction Score: 0.13

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN NOS1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12817894

Sources:
NCI
GABAPENTIN CACNA1F

Interaction Score: 0.1

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1D

Interaction Score: 0.09

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1H

Interaction Score: 0.08

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1S

Interaction Score: 0.07

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN CACNA1C

Interaction Score: 0.07

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GABAPENTIN ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17328248

Sources:
NCI

TEND: GABAPENTIN
- Version: 01-August-2011
Alternate Names:

GABAPENTIN Primary Drug Name

Drug Info:

Drug Class analgesics

Year of Approval 1993

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: GABAPENTIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of neuropathic pain

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: GABAPENTIN

Version: 14-September-2017

Alternate Names:

C1108 NCI drug code

Drug Info:

Publications:

Kang et al., 2007, The effect of MDR1 G2677T/A polymorphism on pharmacokinetics of gabapentin in healthy Korean subjects., Arch. Pharm. Res.

Baydas et al., 2005, Novel role for gabapentin in neuroprotection of central nervous system in streptozotocine-induced diabetic rats., Acta Pharmacol. Sin.

Oka et al., 2003, Gabapentin blocks L-type and P/Q-type Ca2+ channels involved in depolarization-stimulated nitric oxide synthase activity in primary cultures of neurons from mouse cerebral cortex., Pharm. Res.

TTD: Gabapentin
- Version: 2020.06.01
Alternate Names:

D0J0ZS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL940
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL940
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Voltage-gated calcium channel modulator
Direct Interaction	yes
Trial Name	Depomed

Trial Name	Depomed
Novel drug target	Established target
Trial Name	gabapentin,N/

inhibitor (inhibitory)
modulator

inhibitor (inhibitory)
modulator

inhibitor (inhibitory)
modulator

GABAPENTIN Drug Record

GABAPENTIN chembl:CHEMBL940 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory) modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes Trial Name Depomed

PMIDs: 17982508 18299583 20588320 16899342 23435945

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory) modulator

Interaction Info: Trial Name Depomed Novel drug target Established target Trial Name gabapentin,N/

PMIDs: 17982508 20588320 18299583 17067834 16899342 23435945

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15780189

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory) modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator Trial Name Depomed

PMIDs: 16368827 18299583 20588320

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Direct Interaction yes Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info: Mechanism of Interaction Voltage-gated calcium channel modulator Direct Interaction yes

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

Trial Name Depomed

PMIDs:
17982508 18299583 20588320 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Trial Name Depomed

Novel drug target Established target

Trial Name gabapentin,N/

PMIDs:
17982508 20588320 18299583 17067834 16899342 23435945

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
15780189

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

Trial Name Depomed

PMIDs:
16368827 18299583 20588320

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Mechanism of Interaction Voltage-gated calcium channel modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Voltage-gated calcium channel modulator

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

modulator