DGIdb - BMS-754807 Drug Record

BMS-754807 chembl:CHEMBL575448 Antineoplastic

Alternate Names:

BMS-754807

Drug Info:

Drug Class	Kinase Inhibitors
Drug Class	Small molecule
FDA Approval	not approved
Drug Indications	antineoplastic agent

(4 More Sources)

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem
Tognon et al., 2011, ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway., Cancer Res.
Ma et al., 2016, InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma., Clin. Cancer Res.
Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell

BMS-754807 ETV6

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
21148487

Sources:
JAX-CKB
BMS-754807 IGF1R

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Insulin-like growth factor I receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions
BMS-754807 MST1R

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 AXL

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 NTRK2

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 NTRK1

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 AURKB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 INSR

Interaction Score: 0.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Insulin receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC ChemblInteractions
BMS-754807 PTEN

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + Dacomitinib

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26561558

Sources:
JAX-CKB
BMS-754807 MET

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19778024

Sources:
DTC
BMS-754807 KRAS

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + SCH772984

Indication/Tumor Type pancreatic ductal adenocarcinoma

Response Type sensitive

PMIDs:
26725216

Sources:
JAX-CKB
BMS-754807 AKT1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BMS-754807 EGFR

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + Dacomitinib

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26561558

Sources:
JAX-CKB

MyCancerGenome: BMS-754807
- Version: 20-Jun-2017
Alternate Names:

BMS-754807 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:
TdgClinicalTrial: BMS-754807
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:

DTC: BMS-754807

Version: 02-September-2020

Alternate Names:

CHEMBL575448 ChEMBL Drug ID

Drug Info:

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

JAX-CKB: BMS-754807

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Ma et al., 2016, InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma., Clin. Cancer Res.

Tognon et al., 2011, ETV6-NTRK3-mediated breast epithelial cell transformation is blocked by targeting the IGF1R signaling pathway., Cancer Res.

Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell

TTD: BMS-754807
- Version: 2020.06.01
Alternate Names:

D02QWY TTD Drug ID

Drug Info:

Publications:
TALC: BMS-754807
- Version: 12-May-2016
Alternate Names:

BMS-754807 Primary Drug Name

BMS-754807 Drug Synonym

Drug Info:

Publications:
ChemblInteractions: CHEMBL575448
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL575448
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Evidence Type	Actionable
Approval Status	Preclinical
Response Type	sensitive

Mechanism of Interaction	Insulin-like growth factor I receptor inhibitor
Direct Interaction	yes
Notes

Notes
Mechanism of Interaction	Insulin receptor inhibitor
Direct Interaction	yes

combination therapy	BMS-754807 + Dacomitinib
Indication/Tumor Type	glioblastoma multiforme
Response Type	sensitive

combination therapy	BMS-754807 + SCH772984
Indication/Tumor Type	pancreatic ductal adenocarcinoma
Response Type	sensitive

BMS-754807 Drug Record

BMS-754807 chembl:CHEMBL575448 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Evidence Type Actionable Approval Status Preclinical Response Type sensitive

PMIDs: 21148487

Sources: JAX-CKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Insulin-like growth factor I receptor inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Mechanism of Interaction Insulin receptor inhibitor Direct Interaction yes

PMIDs: None found

Sources: TALC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: combination therapy BMS-754807 + Dacomitinib Indication/Tumor Type glioblastoma multiforme Response Type sensitive

PMIDs: 26561558

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19778024

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: combination therapy BMS-754807 + SCH772984 Indication/Tumor Type pancreatic ductal adenocarcinoma Response Type sensitive

PMIDs: 26725216

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info: combination therapy BMS-754807 + Dacomitinib Indication/Tumor Type glioblastoma multiforme Response Type sensitive

PMIDs: 26561558

Sources: JAX-CKB

MyCancerGenome: BMS-754807

Alternate Names: BMS-754807 Development Name

Drug Info: Drug Class Kinase Inhibitors

Publications:

TdgClinicalTrial: BMS-754807

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval not approved

Publications:

DTC: BMS-754807

Alternate Names: CHEMBL575448 ChEMBL Drug ID

Drug Info:

Publications: Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

JAX-CKB: BMS-754807

Alternate Names:

Drug Info:

TTD: BMS-754807

Alternate Names: D02QWY TTD Drug ID

Drug Info:

Publications:

TALC: BMS-754807

Alternate Names: BMS-754807 Primary Drug Name BMS-754807 Drug Synonym

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Evidence Type Actionable

Approval Status Preclinical

Response Type sensitive

PMIDs:
21148487

Sources:
JAX-CKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Insulin-like growth factor I receptor inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Mechanism of Interaction Insulin receptor inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + Dacomitinib

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26561558

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
19778024

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + SCH772984

Indication/Tumor Type pancreatic ductal adenocarcinoma

Response Type sensitive

PMIDs:
26725216

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

combination therapy BMS-754807 + Dacomitinib

Indication/Tumor Type glioblastoma multiforme

Response Type sensitive

PMIDs:
26561558

Sources:
JAX-CKB

Alternate Names:

BMS-754807 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Alternate Names:

CHEMBL575448 ChEMBL Drug ID

Publications:

Wittman MD et al., 2009, Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development., J Med Chem

Alternate Names:

D02QWY TTD Drug ID

Alternate Names:

BMS-754807 Primary Drug Name

BMS-754807 Drug Synonym