DGIdb - SAFINAMIDE Drug Record

SAFINAMIDE chembl:CHEMBL396778 Approved

Alternate Names:

XADAGO
EMD-1195686
SAFINAMIDE
EMD 1195686
XADAGO®
drugbank:06654
chemidplus:133865-89-1
rxcui:1922448
chembl:CHEMBL396778
pubchem.compound:131682

Drug Info:

FDA Approval	not approved
Drug Class	small molecule
Drug Indications	antiparkinson agent

(1 More Sources)

Publications:

Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem
Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem
Marzo et al., 2004, Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity., Pharmacol. Res.
2004, Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E., Drugs R D

SAFINAMIDE MAOB

Interaction Score: 0.73

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

Mechanism of Interaction Monoamine oxidase B inhibitor

PMIDs:
23631427 24560738 15082032 15563241

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD
SAFINAMIDE CACNB3

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE CACNB4

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE CACNA2D2

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE CACNA2D1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE CACNA1B

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Safinamide

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN7A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN8A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN3A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN11A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN2A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN1A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN4A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Safinamide

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN9A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
SAFINAMIDE SCN5A

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

TdgClinicalTrial: SAFINAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiparkinson agent

Drug Class small molecule

FDA Approval not approved

Publications:

DTC: SAFINAMIDE

Version: 02-September-2020

Alternate Names:

CHEMBL396778 ChEMBL Drug ID

Drug Info:

Publications:

Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem

Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem

TTD: Safinamide
- Version: 2020.06.01
Alternate Names:

D0TV6I TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL396778
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL396778
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	Safinamide
Novel drug target	Established target
Mechanism of Interaction	Monoamine oxidase B inhibitor

antagonist (inhibitory)
inhibitor (inhibitory)

SAFINAMIDE Drug Record

SAFINAMIDE chembl:CHEMBL396778 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name Safinamide Novel drug target Established target Mechanism of Interaction Monoamine oxidase B inhibitor

PMIDs: 23631427 24560738 15082032 15563241

Sources: DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Safinamide

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Safinamide

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Safinamide Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

TdgClinicalTrial: SAFINAMIDE

Alternate Names:

Drug Info: Drug Indications antiparkinson agent Drug Class small molecule FDA Approval not approved

Publications:

DTC: SAFINAMIDE

Alternate Names: CHEMBL396778 ChEMBL Drug ID

Drug Info:

Publications: Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem

TTD: Safinamide

Alternate Names: D0TV6I TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL396778

Alternate Names:

Drug Info:

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

Mechanism of Interaction Monoamine oxidase B inhibitor

PMIDs:
23631427 24560738 15082032 15563241

Sources:
DTC TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Safinamide

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Safinamide

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Safinamide

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Drug Info:

Drug Indications antiparkinson agent

Drug Class small molecule

FDA Approval not approved

Alternate Names:

CHEMBL396778 ChEMBL Drug ID

Publications:

Stössel A et al., 2013, Dual targeting of adenosine A(2A) receptors and monoamine oxidase B by 4H-3,1-benzothiazin-4-ones., J Med Chem

Mertens MD et al., 2014, Alkynyl-coumarinyl ethers as MAO-B inhibitors., Bioorg Med Chem

Alternate Names:

D0TV6I TTD Drug ID